Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:APOA1_HUMAN
Description:apolipoprotein A-I [Source:HGNC Symbol;Acc:600]
Location:chr11 q23.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S60SQFEGsALGKQPhosphoSitePlus
S166LQEKLsPLGEEApolipoproteinPhosphoSitePlus
S252ESFKVsFLSALApolipoproteinPhosphoSitePlus
S191HLAPYsDELRQHPRD
Y216ARLAEyHAKATApolipoproteinPhosphoSitePlus
S55GRDYVsQFEGSPhosphoSitePlus
T221YHAKAtEHLSTApolipoproteinPhosphoSitePlus
S191HLAPYsDELRQApolipoproteinPhosphoSitePlus
T185VDALRtHLAPYApolipoproteinPhosphoSitePlus

Dephosphorylation site
APOA1_HUMAN do not have dephosphorylation site.

Mutation site
APOA1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000236850hepatitis C virusNormal vs. CancertissueUp418715028
ENSP00000236850Lung CancerNormal vs. CancertissueDown0.3417705522
ENSP00000236850Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000236850colorectal cancerNormal vs. CancertissueDown0.3915924290
ENSP00000236850Thyroid CarcinomaNormal vs. CancertissueUp3.217194741
ENSP00000236850Thyroid CarcinomaNormal vs. CancertissueUp5.217194741
ENSP00000236850papillary thyroid carcinomaNormal vs. CancertissueUp4.518665625
ENSP00000236850papillary thyroid carcinomaNormal vs. CancertissueUp7.618665625
ENSP00000236850hepatitis C virusNormal vs. CancertissueUp16762624
ENSP00000236850hepatitis B virusNormal vs. CancertissueUp2.617671684
ENSP00000236850Gastric CancerNormal vs. CancertissueUp15559763
ENSP00000236850Gastric CancerNormal vs. CancertissueDown0.6119424620
ENSP00000236850Neoplasms by Histologic TypeCancer vs. Cancer (ER- vs ER+)tissueDown0.8720602252
ENSP00000236850Breast CancerNormal vs. CancertissueDown0.5320739354
ENSP00000236850Breast CancerTreatment (pre- vs. post-chemotherapy)tissueDown20827732
ENSP00000236850Breast CancerTreatment (pre- vs. post-chemotherapy)tissueUp20827732
ENSP00000236850Brain CancerNormal vs. CancertissueUp2.418056677
ENSP00000236850Uterine CancerNormal vs. CancertissueDown16051329
ENSP00000236850Uterine CancerCancer vs. Cancercell lineUp17616526
ENSP00000236850Uterine CancerNormal vs. CancertissueDown19771267
ENSP00000236850Pancreatic CancerNormal vs. CancertissueDown0.3420949480
ENSP00000236850Pancreatic CancerNormal vs. CancertissueDown0.4720949480

Hyperphosphorylation site
APOA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
COT2_HUMANAPOA1_HUMANTF -> target geneTRANSFAC
COT1_HUMANAPOA1_HUMANTF -> target geneTRANSFAC
RARA_HUMANAPOA1_HUMANTF -> target geneTRANSFAC
RARB_HUMANAPOA1_HUMANTF -> target geneTRANSFAC
RXRA_HUMANAPOA1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
APOA1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006629lipid metabolic processTASbiological_process
GO:0070508cholesterol importIMPbiological_process
GO:0030168platelet activationTASbiological_process
GO:0042802identical protein bindingIEAmolecular_function
GO:0015485cholesterol bindingIDAmolecular_function
GO:0034115negative regulation of heterotypic cell-cell adhesIDAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0050821protein stabilizationIDAbiological_process
GO:0006644phospholipid metabolic processIEAbiological_process
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0034384high-density lipoprotein particle clearanceICbiological_process
GO:0001935endothelial cell proliferationIEAbiological_process
GO:0034380high-density lipoprotein particle assemblyIDAbiological_process
GO:0051346negative regulation of hydrolase activityIEAbiological_process
GO:0019915lipid storageIEAbiological_process
GO:0055102lipase inhibitor activityIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0060761negative regulation of response to cytokine stimulIDAbiological_process
GO:0005319lipid transporter activityIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0017127cholesterol transporter activityIEAmolecular_function
GO:0010873positive regulation of cholesterol esterificationIDAbiological_process
GO:0030300regulation of intestinal cholesterol absorptionIEAbiological_process
GO:0006695cholesterol biosynthetic processIEAbiological_process
GO:0034366spherical high-density lipoprotein particleIDAcellular_component
GO:0005576extracellular regionTAScellular_component
GO:0071813lipoprotein particle bindingIEAmolecular_function
GO:0055091phospholipid homeostasisIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0008203cholesterol metabolic processIMPbiological_process
GO:0031100organ regenerationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005548phospholipid transporter activityIEAmolecular_function
GO:0060354negative regulation of cell adhesion molecule prodIDAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0042632cholesterol homeostasisIMPbiological_process
GO:0010903negative regulation of very-low-density lipoproteiIDAbiological_process
GO:0033344cholesterol effluxIEAbiological_process
GO:0008289lipid bindingIEAmolecular_function
GO:0017127cholesterol transporter activityIDAmolecular_function
GO:0050713negative regulation of interleukin-1 beta secretioIDAbiological_process
GO:0030141secretory granuleTAScellular_component
GO:0043691reverse cholesterol transportIMPbiological_process
GO:0030325adrenal gland developmentIEAbiological_process
GO:0034364high-density lipoprotein particleIDAcellular_component
GO:0030301cholesterol transportIDAbiological_process
GO:0008211glucocorticoid metabolic processIEAbiological_process
GO:0005543phospholipid bindingIDAmolecular_function
GO:0001540beta-amyloid bindingIDAmolecular_function
GO:0008035high-density lipoprotein particle bindingIEAmolecular_function
GO:0060228phosphatidylcholine-sterol O-acyltransferase activIDAmolecular_function
GO:0042158lipoprotein biosynthetic processIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0042157lipoprotein metabolic processTASbiological_process
GO:0051347positive regulation of transferase activityIEAbiological_process
GO:0006869lipid transportIEAbiological_process
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0034191apolipoprotein A-I receptor bindingIPImolecular_function
GO:0030301cholesterol transportIEAbiological_process
GO:0018206peptidyl-methionine modificationIDAbiological_process
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0034190apolipoprotein receptor bindingIPImolecular_function
GO:0032489regulation of Cdc42 protein signal transductionIDAbiological_process
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0014012peripheral nervous system axon regenerationIEAbiological_process
GO:0051345positive regulation of hydrolase activityIDAbiological_process
GO:0034375high-density lipoprotein particle remodelingICbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0010804negative regulation of tumor necrosis factor-mediaIDAbiological_process
GO:0033344cholesterol effluxIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0055085transmembrane transportTASbiological_process
GO:0043534blood vessel endothelial cell migrationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030139endocytic vesicleIDAcellular_component
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0070653high-density lipoprotein particle receptor bindingIPImolecular_function
GO:0018158protein oxidationIDAbiological_process
GO:0070328triglyceride homeostasisIDAbiological_process
GO:0015914phospholipid transportIEAbiological_process
GO:0006656phosphatidylcholine biosynthetic processIDAbiological_process
GO:0007584response to nutrientIEAbiological_process
GO:0002740negative regulation of cytokine secretion involvedIDAbiological_process
GO:0060192negative regulation of lipase activityIEAbiological_process
GO:0034361very-low-density lipoprotein particleIDAcellular_component
GO:0033700phospholipid effluxIDAbiological_process
GO:0050728negative regulation of inflammatory responseIDAbiological_process