| UniProt/SwissProt ID: | GNDS_HUMAN |
| Description: | ral guanine nucleotide dissociation stimulator [Source:HGNC Symbol;Acc:9842] |
| Location: | chr9 q34.2 |
| Node attribute: | PPI(source); PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T767 | SSASTtPVAAT | PhosphoSitePlus | |
| Y586 | MKDYLyGRLIN | HPRD | |
| S821 | SILVTsQDKAP | RA | PhosphoSitePlus |
| T820 | KSILVtSQDKA | RA | PhosphoSitePlus |
| S816 | GNMYKsILVTS | RA | PhosphoSitePlus |
| S745 | ESASQsSPETS | PhosphoSitePlus | |
| Y531 | MKDYLyGRLIN | HPRD | |
| S753 | ETSGIsSASSS | PhosphoSitePlus | |
| T542 | TSKFAtLEMNP | RasGEF | PhosphoSitePlus |
| Y584 | TAMKDyLYGRL | RasGEF | PhosphoSitePlus |
| S741 | KKFWEsASQSS | PhosphoSitePlus | |
| Dephosphorylation site |
| GNDS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361120 | R496L | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000361120 | R496L | HPI | Colorectal Cancer | 16959974 | ENSP00000361120 | R114W | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| GNDS_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GNDS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNDS_HUMAN | RHOA_HUMAN | other | KEGG |
| RASK_HUMAN | GNDS_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05200 | Pathways in cancer |
| hsa05212 | Pancreatic cancer |
| hsa05210 | Colorectal cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005083 | small GTPase regulator activity | IDA | molecular_function |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0051056 | regulation of small GTPase mediated signal transdu | IEA | biological_process |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |