| UniProt/SwissProt ID: | DAAM1_HUMAN |
| Description: | dishevelled associated activator of morphogenesis 1 [Source:HGNC Symbol;Acc:18142] |
| Location: | chr14 q23.1 |
| Node attribute: | PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y833 | QRGNAyGFKIS | FH2 | PhosphoSitePlus |
| T255 | YASERtRFQTL | Drf_FH3 | PhosphoSitePlus |
| T1061 | NRKRItNQMTD | PhosphoSitePlus | |
| Y247 | QAMLHyQKYAS | Drf_FH3 | PhosphoSitePlus |
| S799 | VEAIRsGSEEV | FH2 | PhosphoSitePlus |
| T259 | RTRFQtLINDL | Drf_FH3 | PhosphoSitePlus |
| T425 | QDPDStPLENF | Drf_FH3 | PhosphoSitePlus |
| S34 | RLRNDsNFALQ | PhosphoSitePlus | |
| Y401 | GNTVQyWLLLD | Drf_FH3 | PhosphoSitePlus |
| S801 | AIRSGsEEVFR | FH2 | PhosphoSitePlus |
| S678 | DDTLSsKLKVK | HPRD | |
| Dephosphorylation site |
| DAAM1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000247170 | A832G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000247170 | R766* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000247170 | P604L | COSMIC | Skin Cancer | 21984974 | ENSP00000378557 | E763D | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000354162 | E867Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000378557 | P604L | COSMIC | Skin Cancer | 21984974 | ENSP00000378557 | R766* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000378557 | E877Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000247170 | E763D | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000247170 | E877Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000247170 | E750K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000247170 | E492Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000247170 | A832G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000378557 | E492Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000378557 | A832G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000378557 | E750K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000378557 | A832G | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000247170 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| DAAM1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RHOA_HUMAN | DAAM1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04310 | Wnt signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001725 | stress fiber | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0001725 | stress fiber | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0030036 | actin cytoskeleton organization | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0017048 | Rho GTPase binding | IEA | molecular_function |
| GO:0016043 | cellular component organization | IEA | biological_process |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0003779 | actin binding | IEA | molecular_function |