Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DIAP1_HUMAN
Description:diaphanous homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:2876]
Location:chr5 q31.3
Node attribute:PPI(source); PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S54LERFTsMRIKKPhosphoSitePlus
S950KPEIVsVTAACHPRD
T1196AEGDEtGVMDSHPRD
Y773TPKKLyKPEVQFH2PhosphoSitePlus
S373QGEEDsYDLKGDrf_FH3PhosphoSitePlus
Y128EMVSQyLYTSKDrf_GBDPhosphoSitePlus
Y130VSQYLyTSKAGDrf_GBDPhosphoSitePlus
S959KPEIVsVTAACHPRD
T952EIVSVtAACEEHPRD
S22KKKGRsPDELPPhosphoSitePlus; HPRD
S1201TGVMDsLLEALHPRD
S542LEAEVsQLTGEPhosphoSitePlus
S1263LVGRHPRD
S1272LVGRAs_____PhosphoSitePlus
S861TAQNLsIFLGSHPRD
T131SQYLYtSKAGMDrf_GBDPhosphoSitePlus
S857SIFLGsFRMPYHPRD
T768LPFGLtPKKLYFH2PhosphoSitePlus
S1192TGVMDsLLEALHPRD
Y1121KELGEyFLFDPFH2PhosphoSitePlus
S866SIFLGsFRMPYHPRD
S132QYLYTsKAGMSDrf_GBDPhosphoSitePlus
T40KSKKFtLKRLMPhosphoSitePlus
Y374GEEDSyDLKGRDrf_FH3PhosphoSitePlus
S852TAQNLsIFLGSHPRD
S1051KASRVsAENLQFH2PhosphoSitePlus
T961EIVSVtAACEEHPRD
S866SIFLGsFRMPYFH2PhosphoSitePlus
Y75NSSASyGDDPTDrf_GBDPhosphoSitePlus
Y424LVRNDyEARPQDrf_FH3PhosphoSitePlus
S1272LVGRHPRD
T1187AEGDEtGVMDSHPRD
S28PDELPsAGGDGPhosphoSitePlus

Dephosphorylation site
DIAP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000381565S866FCOSMICMelanoma21499247
ENSP00000381565A325VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000381565V1198LCOSMICSkin Cancer21984974

Differential expressed protein
DIAP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DIAP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RHOA_HUMANDIAP1_HUMANotherKEGG
DIAP1_HUMANACTG_HUMANotherKEGG
DIAP1_HUMANDIAP1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05131Shigellosis
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005102receptor bindingNASmolecular_function
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0008360regulation of cell shapeIMPbiological_process
GO:0071420cellular response to histamineIMPbiological_process
GO:0044325ion channel bindingIEAmolecular_function
GO:0072686mitotic spindleIDAcellular_component
GO:0035372protein localization to microtubuleIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0043005neuron projectionIEAcellular_component
GO:0051279regulation of release of sequestered calcium ion iIMPbiological_process
GO:0003779actin bindingIEAmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0016043cellular component organizationIEAbiological_process
GO:0005488bindingIEAmolecular_function
GO:0032587ruffle membraneIEAcellular_component
GO:0007010cytoskeleton organizationIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0017048Rho GTPase bindingIEAmolecular_function
GO:0007605sensory perception of soundIEAbiological_process
GO:0030041actin filament polymerizationIEAbiological_process
GO:0005522profilin bindingIEAmolecular_function
GO:0032886regulation of microtubule-based processIMPbiological_process