Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRF7_HUMAN
Description:interferon regulatory factor 7 [Source:HGNC Symbol;Acc:6122]
Location:chr11 p15.5
Node attribute:PPI(target); substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S479DSSSLsLCLSSPhosphoSitePlus
S472REGVSsLDSSSPhosphoSitePlus
S477SLDSSsLSLCLPhosphoSitePlus
S471QREGVsSLDSSPhosphoSitePlus
T391SASPStPACLLIRF-3PhosphoSitePlus
S53ARKDLsEADARIRFPhosphoSitePlus
S483LSLCLsSANSLPhosphoSitePlus
S487LSSANsLYDDIPhosphoSitePlus

Dephosphorylation site
IRF7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000329411R440CCOSMICHead and Neck Cancer21798893

Differential expressed protein
IRF7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IRF7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TRAF6_HUMANIRF7_HUMANkinase -> substrateKEGG
IRAK1_HUMANIRF7_HUMANkinase -> substrateKEGG
IKKA_HUMANIRF7_HUMANkinase -> substrateKEGG
OSTP_HUMANIRF7_HUMANotherKEGG
IRF7_HUMANIFNB_HUMANTF -> target geneKEGG
IRF7_HUMANIFNA1_HUMANTF -> target geneKEGG
IRF7_HUMANIFNA1_HUMANTF -> target geneTRANSFAC
IRF7_HUMANISG15_HUMANTF -> target geneTRANSFAC
IRF7_HUMANIFNB_HUMANTF -> target geneTRANSFAC
IRF7_HUMANCCL5_HUMANTF -> target geneTRANSFAC
IRF7_HUMANIFN14_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04620Toll-like receptor signaling pathway
hsa05168Herpes simplex infection
hsa05203Viral carcinogenesis
hsa05162Measles
hsa04623Cytosolic DNA-sensing pathway
hsa05160Hepatitis C
hsa05164Influenza A
hsa04622RIG-I-like receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0039530MDA-5 signaling pathwayTASbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0000982RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:2000110negative regulation of macrophage apoptotic procesTASbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0034127regulation of MyD88-independent toll-like receptorISSbiological_process
GO:0032608interferon-beta productionIEAbiological_process
GO:0032607interferon-alpha productionIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0032608interferon-beta productionISSbiological_process
GO:0005829cytosolTAScellular_component
GO:0006473protein acetylationIMPbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific IDAmolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0050776regulation of immune responseTASbiological_process
GO:0045351type I interferon biosynthetic processIEAbiological_process
GO:0016064immunoglobulin mediated immune responseIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0019043establishment of viral latencyTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0009615response to virusTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0032728positive regulation of interferon-beta productionTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034127regulation of MyD88-independent toll-like receptorIEAbiological_process
GO:0000975regulatory region DNA bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0003677DNA bindingIMPmolecular_function
GO:0006974response to DNA damage stimulusTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0002819regulation of adaptive immune responseIDAbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0032479regulation of type I interferon productionTASbiological_process
GO:0034124regulation of MyD88-dependent toll-like receptor sISSbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0034124regulation of MyD88-dependent toll-like receptor sIEAbiological_process
GO:0032727positive regulation of interferon-alpha productionIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0032607interferon-alpha productionISSbiological_process
GO:0005634nucleusTAScellular_component
GO:0060340positive regulation of type I interferon-mediated IEAbiological_process
GO:0045655regulation of monocyte differentiationTASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process