Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PIAS1_HUMAN
Description:protein inhibitor of activated STAT, 1 [Source:HGNC Symbol;Acc:2752]
Location:chr15 q23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S466DLTIDsSSDEEPhosphoSitePlus; HPRD; phosphoELM
T291KQLSStVLLQRPhosphoSitePlus
S485TCPSLsPTSPLPhosphoSitePlus; HPRD; phosphoELM
S328EIATTsLRVSLPhosphoSitePlus
T635TNRSStDTASIHPRD
S289LVKQLsSTVLLPhosphoSitePlus
S290VKQLSsTVLLQPhosphoSitePlus
S506QASPVsRTPSLPhosphoSitePlus; HPRD; phosphoELM
T508SPVSRtPSLPAPhosphoSitePlus
S483KRTCPsLSPTSPhosphoSitePlus; phosphoELM
S90MPATLsPSTIPCHUKHPRD
S476EEEEPsAKRTCPhosphoSitePlus
T327SEIATtSLRVSPhosphoSitePlus
S510VSRTPsLPAVDPhosphoSitePlus
S503LPHQAsPVSRTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T71PQKIMtPADLSPhosphoSitePlus
S467LTIDSsSDEEEPhosphoSitePlus; HPRD; phosphoELM
S522SYINTsLIQDYPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S488SLSPTsPLNNKPhosphoSitePlus; HPRD; phosphoELM
S468TIDSSsDEEEEPhosphoSitePlus; HPRD; phosphoELM
T487PSLSPtSPLNNPhosphoSitePlus; HPRD

Dephosphorylation site
PIAS1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000249636I519MBIOMARTBreast Cancer21930507, 21930502
ENSP00000249636F581LBIOMARTBreast Cancer21930507, 21930502
ENSP00000249636N430SCOSMICLung Cancer20668451

Differential expressed protein
PIAS1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PIAS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IKKA_HUMANPIAS1_HUMANkinase -> substrateHPRD; NetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa05160Hepatitis C
hsa04120Ubiquitin mediated proteolysis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0019789SUMO ligase activityIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007283spermatogenesisIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0016607nuclear speckIEAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0003714transcription corepressor activityTASmolecular_function
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0051152positive regulation of smooth muscle cell differenIEAbiological_process
GO:0060334regulation of interferon-gamma-mediated signaling TASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0050681androgen receptor bindingNASmolecular_function
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0016925protein sumoylationIEAbiological_process
GO:0033235positive regulation of protein sumoylationIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0003713transcription coactivator activityNASmolecular_function
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0065004protein-DNA complex assemblyIEAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function