Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PP1R8_HUMAN
Description:protein phosphatase 1, regulatory subunit 8 [Source:HGNC Symbol;Acc:9296]
Location:chr1 p35.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S178HNKRIsTLTIEPKACaRegPhos
S199RKRKNsRVTFSPhosphoSitePlus; RegPhos
T19LPEEEtELDNLCSNK2A2HPRD
T19LPEEEtELDNLCSNK2A1HPRD
S204SRVTFsEDDEICK2a1-rsRegPhos
S178HNKRIsTLTIEPKA_groupphosphoELM; RegPhos
Y193PKKKKyAKEAWLYNHPRD
S120VSFGAsTRAYTPhosphoSitePlus
S204SRVTFsEDDEIRegPhos
S199RKRKNsRVTFSPKACaRegPhos
S101VEGPGsLGLEEHPRD
S178HNKRIsTLTIEPRKACAHPRD
T121SFGAStRAYTLPhosphoSitePlus
Y264FSGGLyGGLPPLYNHPRD; RegPhos
Y111PKKKKyAKEAWLYNHPRD
T161LPEEEtELDNLCK2a2RegPhos
S25LGLEEsGSRRMHPRD
S62SRVTFsEDDEICSNK2A2HPRD
S204SRVTFsEDDEICK2_groupphosphoELM; RegPhos
Y264FSGGLyGGLPPLynphosphoELM; RegPhos
S204SRVTFsEDDEICK2a2RegPhos
S204SRVTFsEDDEICK2a1RegPhos
Y40FSGGLyGGLPPLYNHPRD
Y335PKKKKyAKEAWLynphosphoELM; RegPhos
T161LPEEEtELDNLCK2_groupphosphoELM; RegPhos
Y335PKKKKyAKEAWLYNHPRD; RegPhos
S19VEGPGsLGLEEHPRD
T161LPEEEtELDNLCK2a1RegPhos
S62SRVTFsEDDEICSNK2A1HPRD
S107LGLEEsGSRRMHPRD
Y335PKKKKyAKEAWPhosphoSitePlus; RegPhos
S57RKRKNsRVTFSPRKACAHPRD
T161LPEEEtELDNLCSNK2A2HPRD
S243VEGPGsLGLEEHPRD
S249LGLEEsGSRRMHPRD; SysPTM
T161LPEEEtELDNLCSNK2A1HPRD
S36HNKRIsTLTIEPRKACAHPRD
S204SRVTFsEDDEICSNK2A2HPRD
S204SRVTFsEDDEICSNK2A1HPRD
Y122FSGGLyGGLPPLYNHPRD
T161LPEEEtELDNLCK2a1-rsRegPhos
S178HNKRIsTLTIEPhosphoSitePlus; phosphoELM
S199RKRKNsRVTFSPRKACAHPRD
S199RKRKNsRVTFSPKA_groupphosphoELM; RegPhos

Dephosphorylation site
PP1R8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000311677G280DCOSMICHead and Neck Cancer21798893

Differential expressed protein
PP1R8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PP1R8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FRK_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
RIOK1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANPP1R8_HUMANkinase -> substrateHPRD
WEE1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
EF2K_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
CSK22_HUMANPP1R8_HUMANkinase -> substrateHPRD
KPCA_HUMANPP1R8_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
RAF1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANPP1R8_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANPP1R8_HUMANkinase -> substrateRegPhos
DYRK2_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
STK16_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
KKCC1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PP1R8_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0003723RNA bindingIEAmolecular_function
GO:0008283cell proliferationIEAbiological_process
GO:0004519endonuclease activityIEAmolecular_function
GO:0006401RNA catabolic processTASbiological_process
GO:0008380RNA splicingIEAbiological_process
GO:0008995ribonuclease E activityTASmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005681spliceosomal complexIEAcellular_component
GO:0004865protein serine/threonine phosphatase inhibitor actTASmolecular_function
GO:0008599protein phosphatase type 1 regulator activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0006397mRNA processingIEAbiological_process
GO:0016607nuclear speckIDAcellular_component
GO:0005515protein bindingIPImolecular_function


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