Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PI51C_HUMAN
Description:phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [Source:HGNC Symbol;Acc:8996]
Location:chr19 p13.3
Node attribute:PPI(source); Enzyme(source); Enzyme(target); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S650RSWVYsPLHYSCDK5HPRD
Y649ERSWVySPLHYCSKRegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S650DERSWVYsPLHYSAQHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000335333S534FCOSMICMelanoma21499247
ENSP00000335333R304WCOSMICGastric Cancer21097718
ENSP00000335333L652FCOSMICGastric Cancer21097718

Differential expressed protein
PI51C_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PI51C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK_HUMANPI51C_HUMANkinase -> substrateRegPhos
CDK5_HUMANPI51C_HUMANkinase -> substrateHPRD
PI3R5_HUMANPI51C_HUMANenzyme catalysisKEGG
PI51C_HUMANPI4KA_HUMANenzyme catalysisKEGG
PLCD3_HUMANPI51C_HUMANenzyme catalysisKEGG
PI51C_HUMANPI3R5_HUMANenzyme catalysisKEGG
PI51C_HUMANPLCD3_HUMANenzyme catalysisKEGG
PI51C_HUMANPTEN_HUMANenzyme catalysisKEGG
PI51C_HUMANI5P2_HUMANenzyme catalysisKEGG
PI51C_HUMANMTM1_HUMANenzyme catalysisKEGG
PTEN_HUMANPI51C_HUMANenzyme catalysisKEGG
PI51C_HUMANPI42A_HUMANenzyme catalysisKEGG
PI51C_HUMANVINC_HUMANotherKEGG
PI51C_HUMANACTG_HUMANotherKEGG
RHOA_HUMANPI51C_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00562Inositol phosphate metabolism
hsa04510Focal adhesion
hsa01100Metabolic pathways
hsa04810Regulation of actin cytoskeleton
hsa04144Endocytosis
hsa04666Fc gamma R-mediated phagocytosis
hsa04070Phosphatidylinositol signaling system

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034333adherens junction assemblyTASbiological_process
GO:0006909phagocytosisTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0016079synaptic vesicle exocytosisTASbiological_process
GO:0072583clathrin-mediated endocytosisTASbiological_process
GO:0001891phagocytic cupIEAcellular_component
GO:0016337cell-cell adhesionTASbiological_process
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0016307phosphatidylinositol phosphate kinase activityIEAmolecular_function
GO:0006644phospholipid metabolic processTASbiological_process
GO:0048488synaptic vesicle endocytosisTASbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activiIEAmolecular_function
GO:0030036actin cytoskeleton organizationTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005925focal adhesionTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0032587ruffle membraneIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0030593neutrophil chemotaxisTASbiological_process
GO:0046488phosphatidylinositol metabolic processIEAbiological_process
GO:0001931uropodTAScellular_component
GO:0012505endomembrane systemIEAcellular_component


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