Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PGFRB_HUMAN
Description:platelet-derived growth factor receptor, beta polypeptide [Source:HGNC Symbol;Acc:8804]
Location:chr5 q32
Node attribute:substrate; kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y771IESSNyMAPYDPDGFRBHPRD
Y579SDGHEyIYVDPPhosphoSitePlus
Y771IESSNyMAPYDPDGFRbRegPhos
Y1021EGDNDyIIPLPPDGFRBHPRD
Y678KGGPIyIITEYPkinase_TyrPhosphoSitePlus
Y857MRDSNyISKGSPDGFR_betaphosphoELM
Y763KGDVKyADIESPDGFRBHPRD
Y763KGDVKyADIESPDGFRbRegPhos
Y716PSAELySNALPPDGFRBHPRD
Y716PSAELySNALPPDGFRbRegPhos
Y934ASDEIyEIMQKPkinase_TyrPhosphoSitePlus; SysPTM
Y857MRDSNyISKGSPDGFR_groupphosphoELM; RegPhos
Y763KGDVKyADIESPDGFR_betaphosphoELM
Y771IESSNyMAPYDPkinase_TyrPhosphoSitePlus
Y775NYMAPyDNYVPPDGFRbRegPhos
Y857MRDSNyISKGSPDGFRBHPRD
Y692GDLVDyLHRNKPkinase_TyrPhosphoSitePlus
Y775NYMAPyDNYVPPDGFR_betaphosphoELM
Y1021EGDNDyIIPLPPhosphoSitePlus
Y562QKKPRyEIRWKPhosphoSitePlus
Y751DESVDyVPMLDPDGFR_betaphosphoELM
S930QPAHAsDEIYEPkinase_TyrPhosphoSitePlus
Y751DESVDyVPMLDautocatalysisRegPhos
S1104AEAEDsFLBARK1(GRK2RegPhos
Y740ESDGGyMDMSKPDGFR_betaphosphoELM
Y778APYDNyVPSAPPkinase_TyrPhosphoSitePlus
Y763KGDVKyADIESPkinase_TyrPhosphoSitePlus
Y775NYMAPyDNYVPPDGFRBHPRD
Y716PSAELySNALPPkinase_TyrPhosphoSitePlus
Y751DESVDyVPMLDPDGFRbRegPhos
Y751DESVDyVPMLDPDGFRBHPRD
Y1021EGDNDyIIPLPPDGFRbRegPhos
Y1009TSSVLyTAVQPPDGFRbRegPhos
Y1009TSSVLyTAVQPPDGFRBHPRD
Y562QKKPRyEIRWKPDGFR_betaphosphoELM
Y763KGDVKyADIESphosphoELM
Y921AIKRGyRMAQPPkinase_TyrPhosphoSitePlus
Y778APYDNyVPSAPphosphoELM
Y686TEYCRyGDLVDPkinase_TyrPhosphoSitePlus
Y579SDGHEyIYVDPPDGFRBHPRD
Y771IESSNyMAPYDPDGFR_betaphosphoELM
Y970GYKKKyQQVDEPhosphoSitePlus
Y857MRDSNyISKGSPDGFRbRegPhos
S1104AEAEDsFL___PhosphoSitePlus
Y579SDGHEyIYVDPPDGFR_betaphosphoELM
Y775NYMAPyDNYVPPkinase_TyrPhosphoSitePlus
Y751DESVDyVPMLDPkinase_TyrPhosphoSitePlus
T605LVLGRtLGSGAPkinase_TyrPhosphoSitePlus
Y581GHEYIyVDPMQPDGFRBHPRD
Y581GHEYIyVDPMQPDGFRbRegPhos
Y716PSAELySNALPPDGFR_betaphosphoELM
Y857MRDSNyISKGSautocatalysisRegPhos
Y562QKKPRyEIRWKPDGFRbRegPhos
Y1021EGDNDyIIPLPPDGFR_betaphosphoELM
Y778APYDNyVPSAPPDGFR_betaphosphoELM
Y934ASDEIyEIMQKHPRD; SysPTM
Y751DESVDyVPMLDPDGFR_groupphosphoELM; RegPhos
Y1009TSSVLyTAVQPPhosphoSitePlus
Y740ESDGGyMDMSKPDGFRBHPRD
Y740ESDGGyMDMSKPDGFRbRegPhos
Y740ESDGGyMDMSKPkinase_TyrPhosphoSitePlus
Y581GHEYIyVDPMQPDGFR_betaphosphoELM
S608GRTLGsGAFGQPkinase_TyrPhosphoSitePlus
Y579SDGHEyIYVDPPDGFRbRegPhos
Y778APYDNyVPSAPPDGFRbRegPhos
Y581GHEYIyVDPMQPhosphoSitePlus
Y1009TSSVLyTAVQPPDGFR_betaphosphoELM
S1104AEAEDsGRK-2phosphoELM
Y857MRDSNyISKGSPkinase_TyrPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1021PNEGDNDyIIPLPDPPTPN2HPRD
Y1009LDTSSVLyTAVQPNEPTPN11HPRD
Y771ADIESSNyMAPYDNYPTPN2HPRD
Y751SKDESVDyVPMLDMKPTPRJHPRD
Y562LWQKKPRyEIRWKVIPTPRJHPRD
Y751SKDESVDyVPMLDMKPTPN11HPRD
Y751SKDESVDyVPMLDMKPTPN2HPRD
Y771ADIESSNyMAPYDNYPTPN1HPRD
Y579VSSDGHEyIYVDPMQPTPN2HPRD
Y1021PNEGDNDyIIPLPDPPTPRJHPRD
Y857DIMRDSNyISKGSTFPTPRJHPRD
Y740TGESDGGyMDMSKDEPTPN11HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261799Y589HGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000261799Q155*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000261799T545IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000261799T882IGreenman2007Breast Cancer15908952, 17344846, 18428421
ENSP00000261799I182MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000261799T882IHPIbreast ductal carcinoma17344846

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000261799Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
PGFRB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDGFD_HUMANPGFRB_HUMANligand -> receptorHPMR
PDGFB_HUMANPGFRB_HUMANligand -> receptorHPMR
PGFRB_HUMANPGFRB_HUMANkinase -> substrateRegPhos
PGFRB_HUMANSHC1_HUMANkinase -> substrateRegPhos
PGFRB_HUMANEZRI_HUMANkinase -> substrateRegPhos
ARBK1_HUMANPGFRB_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PGFRB_HUMANMUC1_HUMANkinase -> substrateRegPhos
PGFRB_HUMANPLCG1_HUMANkinase -> substrateRegPhos
PGFRB_HUMANFYN_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
PGFRB_HUMANRASA1_HUMANkinase -> substrateRegPhos
PGFRB_HUMANSH2B1_HUMANkinase -> substrateRegPhos
PGFRB_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
PGFRB_HUMANPTN11_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PTN1_HUMANPGFRB_HUMANphosphatase -> substrateHPRD
PTN11_HUMANPGFRB_HUMANphosphatase -> substrateHPRD
PTPRJ_HUMANPGFRB_HUMANphosphatase -> substrateHPRD
PTN2_HUMANPGFRB_HUMANphosphatase -> substrateHPRD
PDGFB_HUMANPGFRB_HUMANotherKEGG
PKHO2_HUMANPGFRB_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05214Glioma
hsa04020Calcium signaling pathway
hsa05218Melanoma
hsa04510Focal adhesion
hsa04060Cytokine-cytokine receptor interaction
hsa04540Gap junction
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa04810Regulation of actin cytoskeleton
hsa04010MAPK signaling pathway
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIEAmolecular_function
GO:2000573positive regulation of DNA biosynthetic processISSbiological_process
GO:0004992platelet activating factor receptor activityTASmolecular_function
GO:0048010vascular endothelial growth factor receptor signalIEAbiological_process
GO:0072275metanephric glomerulus morphogenesisIEAbiological_process
GO:0090280positive regulation of calcium ion importISSbiological_process
GO:0032967positive regulation of collagen biosynthetic proceIEAbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007165signal transductionIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035909aorta morphogenesisISSbiological_process
GO:0048745smooth muscle tissue developmentIEAbiological_process
GO:0050921positive regulation of chemotaxisISSbiological_process
GO:0005021vascular endothelial growth factor-activated recepIEAmolecular_function
GO:0072075metanephric mesenchyme developmentIEAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0010863positive regulation of phospholipase C activityIDAbiological_process
GO:0060326cell chemotaxisIDAbiological_process
GO:0045840positive regulation of mitosisISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0016477cell migrationIMPbiological_process
GO:0048661positive regulation of smooth muscle cell proliferISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0035793positive regulation of metanephric mesenchymal celISSbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0032516positive regulation of phosphoprotein phosphatase IDAbiological_process
GO:0006807nitrogen compound metabolic processIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0072278metanephric comma-shaped body morphogenesisIEAbiological_process
GO:0036120cellular response to platelet-derived growth factoTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:2000379positive regulation of reactive oxygen species metISSbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0038085vascular endothelial growth factor bindingIPImolecular_function
GO:0032526response to retinoic acidIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0034405response to fluid shear stressIEAbiological_process
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0038091positive regulation of cell proliferation by VEGF-IDAbiological_process
GO:0072277metanephric glomerular capillary formationISSbiological_process
GO:0005017platelet-derived growth factor-activated receptor TASmolecular_function
GO:0031226intrinsic to plasma membraneIDAcellular_component
GO:0001894tissue homeostasisIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0072262metanephric glomerular mesangial cell proliferatioISSbiological_process
GO:0035791platelet-derived growth factor receptor-beta signaIMPbiological_process
GO:0033993response to lipidIEAbiological_process
GO:0032956regulation of actin cytoskeleton organizationISSbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0005161platelet-derived growth factor receptor bindingIPImolecular_function
GO:0061298retina vasculature development in camera-type eyeISSbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0030325adrenal gland developmentIEAbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0072284metanephric S-shaped body morphogenesisIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0014911positive regulation of smooth muscle cell migratioISSbiological_process
GO:0043548phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0055003cardiac myofibril assemblyISSbiological_process
GO:0016020membraneIDAcellular_component
GO:0055093response to hyperoxiaIEAbiological_process
GO:0060981cell migration involved in coronary angiogenesisISSbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0043202lysosomal lumenIEAcellular_component
GO:0046488phosphatidylinositol metabolic processIMPbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0043406positive regulation of MAP kinase activityISSbiological_process
GO:0048407platelet-derived growth factor bindingIPImolecular_function
GO:0009636response to toxinIEAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006024glycosaminoglycan biosynthetic processIEAbiological_process
GO:0005019platelet-derived growth factor beta-receptor activIDAmolecular_function
GO:0014068positive regulation of phosphatidylinositol 3-kinaISSbiological_process
GO:0035789metanephric mesenchymal cell migrationIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingIMPbiological_process
GO:0071670smooth muscle cell chemotaxisISSbiological_process
GO:0042060wound healingIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0035441cell migration involved in vasculogenesisISSbiological_process