Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NOD1_HUMAN
Description:nucleotide-binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:16390]
Location:chr7 p14.3
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S217LQRLQsLWATGNACHTPhosphoSitePlus
T334LLTARtGIEVPNACHTPhosphoSitePlus
Y129DPVSRyTQQLRPhosphoSitePlus

Dephosphorylation site
NOD1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000222823P549LCOSMICSkin Cancer21984974
ENSP00000222823K746TCOSMICOvarian Cancer21720365
ENSP00000222823L578PCOSMICOvarian Cancer21720365
ENSP00000222823F271LCOSMICMelanoma21499247

Differential expressed protein
NOD1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NOD1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NOD1_HUMANNFKB1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa05133Pertussis
hsa05131Shigellosis
hsa04621NOD-like receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008656cysteine-type endopeptidase activator activity invTASmolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0032760positive regulation of tumor necrosis factor produIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0042228interleukin-8 biosynthetic processIDAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0046330positive regulation of JNK cascadeIEAbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0042834peptidoglycan bindingTASmolecular_function
GO:0050700CARD domain bindingIDAmolecular_function
GO:0006917induction of apoptosisIDAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0035556intracellular signal transductionIDAbiological_process
GO:0009595detection of biotic stimulusTASbiological_process
GO:0042742defense response to bacteriumIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0002606positive regulation of dendritic cell antigen procIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0006952defense responseTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0032874positive regulation of stress-activated MAPK cascaIEAbiological_process
GO:0016045detection of bacteriumIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0007254JNK cascadeTASbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0051259protein oligomerizationTASbiological_process
GO:0050830defense response to Gram-positive bacteriumIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0042802identical protein bindingIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0032755positive regulation of interleukin-6 productionIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process