Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NEK9_HUMAN
Description:NIMA-related kinase 9 [Source:HGNC Symbol;Acc:18591]
Location:chr14 q24.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S413HGDKAsYRQPKRCC1PhosphoSitePlus
S332KRPRSsTVTEAPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S869QVEASsPRLNPPhosphoSitePlus; HPRD; RegPhos; SysPTM
S748GTVFQsSSPGGHPRD
S829MPDSPsPLSAAPhosphoSitePlus; HPRD
T886KGTPLtPPACAPhosphoSitePlus; SysPTM
S35PGPSAsQGPRAPhosphoSitePlus
T795GLISPtEAMGNHPRD
T685GRLAMtPTERPHPRD
Y509WGCGEyGRLGLRCC1PhosphoSitePlus
T333RPRSStVTEAPPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S868PQVEAsSPRLNPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S331TKRPRsSTVTEPhosphoSitePlus; HPRD
S29GCGDSsPGPSAPhosphoSitePlus; SysPTM
S2LGEYHPRD; SysPTM
S28GGCGDsSPGPSPhosphoSitePlus; HPRD
S836LSAAFsESEKDPhosphoSitePlus; HPRD
T210YSMAEtLVGTPPkinasePhosphoSitePlus
S735SKTIRsNSSGLPhosphoSitePlus
T358GGGKStPQKLDNEK9HPRD
T254RTFDAtNPLNLPkinasePhosphoSitePlus; SysPTM
T358GGGKStPQKLDPhosphoSitePlus; phosphoELM; RegPhos
S805NSNGAsSSCPGHPRD
S964KPDLDsDSWCLHPRD
T886KGTPLtPPACANEK9HPRD; SysPTM
T210YSMAEtLVGTPNEK9phosphoELM; RegPhos
Y52QEELHyIPIRVPkinasePhosphoSitePlus
S944QVGMHsKGTQTPhosphoSitePlus; HPRD; SysPTM
S868PQVEAsSPRLNNEK9HPRD; SysPTM
T842ESEKDtLPYEEPhosphoSitePlus
T210YSMAEtLVGTPHPRD; RegPhos
S978DSCRPHPRD; SysPTM
T333RPRSStVTEAPNEK9HPRD; SysPTM
Y845KDTLPyEELQGPhosphoSitePlus
Y520DSEEDyYTPQKRCC1PhosphoSitePlus
S749TVFQSsSPGGGHPRD
S832SPSPLsAAFSEPhosphoSitePlus; HPRD
T326LLNAPtKRPRSPhosphoSitePlus
S838AAFSEsEKDTLPhosphoSitePlus; HPRD
S20NSDFGsESGGCPhosphoSitePlus; HPRD
S16CDSINsDFGSEPhosphoSitePlus; HPRD
T72TLYRRtEDDSLPkinasePhosphoSitePlus
S2____MsVLGEYPhosphoSitePlus; SysPTM
S765GEEEDsQQESEHPRD
S741NSSGLsIGTVFPhosphoSitePlus; HPRD; SysPTM
S332KRPRSsTVTEANEK9HPRD; SysPTM
S801EAMGNsNGASSPhosphoSitePlus; HPRD
S793MEGLIsPTEAMPhosphoSitePlus; HPRD; SysPTM
S769DSQQEsETPDPHPRD
S29GCGDSsPGPSANEK9HPRD; SysPTM
T335RSSTVtEAPIAPhosphoSitePlus
T335RSSTVtEAPIANEK9HPRD
T883CAGKGtPLTPPPhosphoSitePlus; HPRD
T210YSMAEtLVGTPautocatalysis RegPhos
S13ERHCDsINSDFPhosphoSitePlus; HPRD
S357WGGGKsTPQKLHPRD
S76RTEDDsLVVWKHPRD; SysPTM
S827IPMPDsPSPLSPhosphoSitePlus; HPRD; SysPTM
S978DSCRPsL____PhosphoSitePlus; SysPTM
T732VLNSKtIRSNSPhosphoSitePlus
Y350RTSEVyVWGGGPhosphoSitePlus
S974LLGTDsCRPHPRD
S735SKTIRsNSSGLNEK9HPRD
S76RTEDDsLVVWKPkinasePhosphoSitePlus; SysPTM
T254RTFDAtNPLNLHPRD; SysPTM
S750VFQSSsPGGGGPhosphoSitePlus; HPRD; SysPTM

Dephosphorylation site
NEK9_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000238616R637CCOSMICHead and Neck Cancer21798893
ENSP00000238616E316KCOSMICSkin Cancer21984974
ENSP00000238616R786QCOSMICGastric Cancer21097718
ENSP00000238616V319fs*16COSMICOvarian Cancer
ENSP00000238616V631ICOSMICGastric Cancer21097718
ENSP00000238616P870SHPI, COSMICLung Cancer17344846, 16140923

Differential expressed protein
NEK9_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NEK9_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK9_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANNEK6_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
NEK9_HUMANPHLA2_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANPLK1_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANNEK9_HUMANkinase -> substrateRegPhos
NEK9_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANGRK5_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANNEK7_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
NEK9_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANVPS39_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANNEK9_HUMANkinase -> substrateRegPhos
NEK9_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NEK9_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046872metal ion bindingIEAmolecular_function
GO:0007067mitosisIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005739mitochondrionIDAcellular_component


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