Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LRP1_HUMAN
Description:low density lipoprotein receptor-related protein 1 [Source:HGNC Symbol;Acc:6692]
Location:chr12 q13.3
Node attribute:receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1432HRETGsGGWPNLdl_recept_bPhosphoSitePlus
S4517MGGHGsRHSLAPhosphoSitePlus; RegPhos
Y1443GLTVDyLEKRILdl_recept_bPhosphoSitePlus
Y4507FTNPVyATLYMPhosphoSitePlus; RegPhos
S1754IDFPEsKLYWIPhosphoSitePlus
T648IEGKMtHPRAILdl_recept_bPhosphoSitePlus
Y4473IGNPTyKMYEGPhosphoSitePlus
T1430TVHREtGSGGWLdl_recept_bPhosphoSitePlus
Y530ELFLVyGKGRPPhosphoSitePlus
S4249GTCAAsPSGMPEGFPhosphoSitePlus
T2156DRQKGtNVCAVPhosphoSitePlus
S4517MGGHGsRHSLAPKA_groupphosphoELM; RegPhos
Y4507FTNPVyATLYMSrcRegPhos
S4520HGSRHsLASTDPKACaRegPhos
S4520HGSRHsLASTDPKA_groupphosphoELM; RegPhos
Y2290VEGLAyHRGWDPhosphoSitePlus
T4460QHQRMtNGAMNPhosphoSitePlus; RegPhos
S4523RHSLAsTDEKRPhosphoSitePlus; HPRD; RegPhos
S4067ADAKLsVIGSILdl_recept_bPhosphoSitePlus
T1790QLGKAtALAIMPhosphoSitePlus
T1513TGHNVtVVQRTPhosphoSitePlus; HPRD
S2621TCIGNsSRCNQLdl_recept_aPhosphoSitePlus
T1498WTDWRtNTLAKPhosphoSitePlus
S3217YIEFAsLDGSNHPRD
S4520HGSRHsLASTDPhosphoSitePlus; RegPhos
Y1587KKFLLyARQMEPhosphoSitePlus
Y4507FTNPVyATLYMSRCHPRD; phosphoELM; RegPhos
S3928TISYRsLPPAAPhosphoSitePlus
S4520HGSRHsLASTDPRKACAHPRD
S4071LSVIGsIRLNGLdl_recept_bPhosphoSitePlus
T1440WPNGLtVDYLELdl_recept_bPhosphoSitePlus
Y4511VYATLyMGGHGPhosphoSitePlus
T1500DWRTNtLAKANPhosphoSitePlus; HPRD

Dephosphorylation site
LRP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000243077R3760HHPIColorectal Cancer16959974
ENSP00000243077G4316VCOSMICOvarian Cancer21720365
ENSP00000243077N2048KCOSMICOvarian Cancer21720365
ENSP00000243077S970LCOSMICMelanoma21499247
ENSP00000243077E1369KCOSMICOvarian Cancer21720365
ENSP00000243077T3738SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000243077P3733SCOSMICBreast Cancer20668451
ENSP00000243077L1893VBIOMARTBreast Cancer21930507, 21930502
ENSP00000243077N3682SCOSMICOvarian Cancer21720365
ENSP00000243077E869KSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000243077K1109RTCGAOvarian Cancer21720365, 18772890
ENSP00000243077R793*COSMICPancreatic Cancer
ENSP00000243077R3760HSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000243077I2255MBIOMARTBreast Cancer21930507, 21930502
ENSP00000243077A2633TCOSMICOvarian Cancer21720365
ENSP00000243077G4316VTCGAOvarian Cancer21720365, 18772890
ENSP00000243077R4176QCOSMICPancreatic Cancer21252315
ENSP00000243077R1423CTCGAOvarian Cancer21720365, 18772890
ENSP00000243077T2979MCOSMICOvarian Cancer20668451
ENSP00000243077P2379SCOSMICSkin Cancer21984974
ENSP00000243077E869KHPIColorectal Cancer16959974
ENSP00000243077K1109RCOSMICOvarian Cancer21720365
ENSP00000243077L2209VBIOMARTBreast Cancer21930507, 21930502
ENSP00000243077Y574*TCGAOvarian Cancer21720365, 18772890
ENSP00000243077Q981ECOSMICLung Cancer20668451
ENSP00000243077I404LCOSMICBreast Cancer20668451
ENSP00000243077R2032CBIOMARTBreast Cancer21930507, 21930502
ENSP00000243077R1281CBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000243077R1423CCOSMICOvarian Cancer21720365
ENSP00000243077Y574*COSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000243077Uterine CancerNormal vs. CancertissueDown17902640

Hyperphosphorylation site
LRP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
A2MG_HUMANLRP1_HUMANligand -> receptorHPMR
CO3_HUMANLRP1_HUMANligand -> receptorHPMR
MMP13_HUMANLRP1_HUMANligand -> receptorHPMR
ANT3_HUMANLRP1_HUMANligand -> receptorHPMR
TRFL_HUMANLRP1_HUMANligand -> receptorHPMR
FA9_HUMANLRP1_HUMANligand -> receptorHPMR
MMP9_HUMANLRP1_HUMANligand -> receptorHPMR
PAI1_HUMANLRP1_HUMANligand -> receptorHPMR
SFTA1_HUMANLRP1_HUMANligand -> receptorHPMR
FA8_HUMANLRP1_HUMANligand -> receptorHPMR
A1AT_HUMANLRP1_HUMANligand -> receptorHPMR
IC1_HUMANLRP1_HUMANligand -> receptorHPMR
AMRP_HUMANLRP1_HUMANligand -> receptorHPMR
ENPL_HUMANLRP1_HUMANligand -> receptorHPMR
UROK_HUMANLRP1_HUMANligand -> receptorHPMR
TPA_HUMANLRP1_HUMANligand -> receptorHPMR
ZAGL2_HUMANLRP1_HUMANkinase -> substrateRegPhos
KPCA_HUMANLRP1_HUMANkinase -> substrateHPRD
SRC_HUMANLRP1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05144Malaria
hsa05010Alzheimer's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0014912negative regulation of smooth muscle cell migratioIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0043277apoptotic cell clearanceISSbiological_process
GO:0016020membraneIEAcellular_component
GO:0005905coated pitIEAcellular_component
GO:0014912negative regulation of smooth muscle cell migratioISSbiological_process
GO:0034185apolipoprotein bindingIPImolecular_function
GO:0032370positive regulation of lipid transportISSbiological_process
GO:0035909aorta morphogenesisIEAbiological_process
GO:0042954lipoprotein transporter activityNASmolecular_function
GO:0035909aorta morphogenesisISSbiological_process
GO:0032429regulation of phospholipase A2 activityISSbiological_process
GO:0032403protein complex bindingIDAmolecular_function
GO:2000587negative regulation of platelet-derived growth facIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0032374regulation of cholesterol transportISSbiological_process
GO:0005887integral to plasma membraneISScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030178negative regulation of Wnt receptor signaling pathISSbiological_process
GO:0010875positive regulation of cholesterol effluxISSbiological_process
GO:2000587negative regulation of platelet-derived growth facISSbiological_process
GO:0032956regulation of actin cytoskeleton organizationISSbiological_process
GO:0032374regulation of cholesterol transportIEAbiological_process
GO:0043277apoptotic cell clearanceIEAbiological_process
GO:0042953lipoprotein transportNASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0004872receptor activityTASmolecular_function
GO:0005887integral to plasma membraneIEAcellular_component
GO:0032429regulation of phospholipase A2 activityIEAbiological_process
GO:0032370positive regulation of lipid transportIEAbiological_process
GO:0010875positive regulation of cholesterol effluxIEAbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0005509calcium ion bindingISSmolecular_function
GO:0070325lipoprotein particle receptor bindingICmolecular_function
GO:0032956regulation of actin cytoskeleton organizationIEAbiological_process
GO:0097242beta-amyloid clearanceIEAbiological_process
GO:0006898receptor-mediated endocytosisIEAbiological_process
GO:0097242beta-amyloid clearanceTASbiological_process


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