Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRFL_HUMAN
Description:lactotransferrin [Source:HGNC Symbol;Acc:6720]
Location:chr3 p21.31
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T480KKSCHtAVDRTTransferrinPhosphoSitePlus
S477VKGKKsCHTAVTransferrinPhosphoSitePlus
T485TAVDRtAGWNITransferrinPhosphoSitePlus
Y545SNERYyGYTGATransferrinPhosphoSitePlus
Y211EPYFSySGAFKTransferrinPhosphoSitePlus
Y454RPVEGyLAVAVTransferrin; Abhydrolase_PhosphoSitePlus
S278AVVARsVNGKEHPRD
S501FNQTGsCKFDETransferrinPhosphoSitePlus
Y111QPRTHyYAVAVTransferrinPhosphoSitePlus
T499LLFNQtGSCKFTransferrinPhosphoSitePlus
Y547ERYYGyTGAFRTransferrinPhosphoSitePlus
S278AVVARsVNGKETransferrinPhosphoSitePlus
Y547ERYYGyTGAFRphosphoELM
Y112PRTHYyAVAVVTransferrinPhosphoSitePlus

Dephosphorylation site
TRFL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000231751V388EDing2008, COSMICLung Cancer18948947
ENSP00000231751T677ICOSMICHead and Neck Cancer21798893
ENSP00000231751E85KCOSMICHead and Neck Cancer21798893
ENSP00000405719*667YCOSMICOvarian Cancer21720365
ENSP00000231751K119NCOSMICOvarian Cancer21720365
ENSP00000231751R190CCOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000231751Lung CancerNormal vs. CancertissueUp3.217705522
ENSP00000231751Neoplasms by Histologic TypeNormal vs. CancertissueUp1.618259946
ENSP00000231751Neoplasms by Histologic TypeNormal vs. CancertissueUp1.318259946
ENSP00000231751Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000231751Breast CancerNormal vs. CancertissueDown0.4820739354

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y547TransferrinSNERYYGyTGAFRCLcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
TRFL_HUMANLRP11_HUMANligand -> receptorHPMR
TRFL_HUMANLRP1_HUMANligand -> receptorHPMR
ERR1_HUMANTRFL_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TRFL_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051701interaction with hostTASbiological_process
GO:0006959humoral immune responseTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0008233peptidase activityIEAmolecular_function
GO:0090382phagosome maturationTASbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0097013phagocytic vesicle lumenTAScellular_component
GO:0042742defense response to bacteriumIEAbiological_process
GO:0004252serine-type endopeptidase activityTASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006826iron ion transportIEAbiological_process
GO:0008201heparin bindingIDAmolecular_function
GO:0033214iron assimilation by chelation and transportTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0052572response to host immune responseTASbiological_process
GO:0006879cellular iron ion homeostasisIEAbiological_process
GO:0008199ferric iron bindingIEAmolecular_function
GO:0030141secretory granuleIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function