Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:A1AT_HUMAN
Description:serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 [Source:HGNC Symbol;Acc:8941]
Location:chr14 q32.13
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T416KVVNPtQK___PhosphoSitePlus
S261CKKLSsWVLLMSerpinPhosphoSitePlus
Y321SITGTyDLKSVSerpinPhosphoSitePlus
T333GQLGItKVFSNSerpinPhosphoSitePlus
S383EAIPMsIPPEVHPRD
T333GQLGItKVFSNHPRD
Y184KQINDyVEKGTSerpinPhosphoSitePlus

Dephosphorylation site
A1AT_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000348068G29RCOSMICSkin Cancer21984974
ENSP00000416354G29RCOSMICSkin Cancer21984974
ENSP00000376803P130LCOSMICSkin Cancer21984974
ENSP00000408474P130LCOSMICSkin Cancer21984974
ENSP00000376802P130LCOSMICSkin Cancer21984974
ENSP00000416066P130LCOSMICSkin Cancer21984974
ENSP00000416354P130LCOSMICSkin Cancer21984974
ENSP00000385960G29RCOSMICSkin Cancer21984974
ENSP00000376803G29RCOSMICSkin Cancer21984974
ENSP00000376802A166VCOSMICSkin Cancer21984974
ENSP00000416066S354FCOSMICSkin Cancer21984974
ENSP00000390299S354FCOSMICSkin Cancer21984974
ENSP00000408474G29RCOSMICSkin Cancer21984974
ENSP00000408474S354FCOSMICSkin Cancer21984974
ENSP00000348068A166VCOSMICSkin Cancer21984974
ENSP00000376803S354FCOSMICSkin Cancer21984974
ENSP00000390299A166VCOSMICSkin Cancer21984974
ENSP00000416066G29RCOSMICSkin Cancer21984974
ENSP00000376802G29RCOSMICSkin Cancer21984974
ENSP00000385960S354FCOSMICSkin Cancer21984974
ENSP00000376803A166VCOSMICSkin Cancer21984974
ENSP00000348068P130LCOSMICSkin Cancer21984974
ENSP00000416354S354FCOSMICSkin Cancer21984974
ENSP00000416066A166VCOSMICSkin Cancer21984974
ENSP00000408474A166VCOSMICSkin Cancer21984974
ENSP00000416354A166VCOSMICSkin Cancer21984974
ENSP00000390299G29RCOSMICSkin Cancer21984974
ENSP00000390299P130LCOSMICSkin Cancer21984974
ENSP00000385960P130LCOSMICSkin Cancer21984974
ENSP00000348068S354FCOSMICSkin Cancer21984974
ENSP00000376802S354FCOSMICSkin Cancer21984974
ENSP00000385960A166VCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000348068colorectal cancerNormal vs. CancertissueDown0.619098285
ENSP00000348068Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000348068papillary thyroid carcinomaNormal vs. CancertissueUp2.116788983
ENSP00000348068pancreatic ductal adenocarcinomaNormal vs. CancertissueUp3.118366394
ENSP00000348068pancreatic ductal adenocarcinomaNormal vs. CancertissueUp3.418366394
ENSP00000348068Breast CancerMetastasiscell lineUp17608509
ENSP00000348068hepatitis B virusNormal vs. CancertissueUp515852300
ENSP00000348068hepatitis B virusNormal vs. CancertissueUp16240287
ENSP00000348068Hepatocellular CarcinomaNormal vs. CancertissueUp16240287
ENSP00000348068hepatitis C virusNormal vs. CancertissueDown16762624
ENSP00000348068hepatitis C virusNormal vs. CancertissueUp16762624
ENSP00000348068Hepatocellular CarcinomaMetastasiscell lineDown0.2619016532
ENSP00000348068hepatitis B virusNormal vs. CancertissueUp320525558
ENSP00000348068Neoplasms by Histologic TypeNormal vs. CancertissueUp612874873
ENSP00000348068Gastric CancerNormal vs. CancertissueDown17154271
ENSP00000348068Gastric CancerNormal vs. CancertissueDown0.4519330469
ENSP00000348068Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueUp3.419422301
ENSP00000348068Esophageal CancerNormal vs. CancertissueDown0.4316400690

Hyperphosphorylation site
A1AT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
A1AT_HUMANLRP1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0034014response to triglycerideIEAbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0005576extracellular regionNAScellular_component
GO:0010288response to lead ionIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0010951negative regulation of endopeptidase activityIBAbiological_process
GO:0004866endopeptidase inhibitor activityIEAmolecular_function
GO:0030162regulation of proteolysisIBAbiological_process
GO:0033986response to methanolIEAbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0002020protease bindingIPImolecular_function
GO:0004867serine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0046687response to chromateIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006953acute-phase responseIEAbiological_process