| UniProt/SwissProt ID: | MMP13_HUMAN |
| Description: | matrix metallopeptidase 13 (collagenase 3) [Source:HGNC Symbol;Acc:7159] |
| Location: | chrHG305_PATCH q22.2 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y366 | DILEGyPKKIS | Hemopexin | PhosphoSitePlus |
| Y360 | WALNGyDILEG | Hemopexin | PhosphoSitePlus |
| Dephosphorylation site |
| MMP13_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000260302 | D30N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000260302 | V462I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000260302 | D100N | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| MMP13_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MMP13_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MMP13_HUMAN | LRP1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| MMP13_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051216 | cartilage development | IEA | biological_process |
| GO:0022617 | extracellular matrix disassembly | TAS | biological_process |
| GO:0044267 | cellular protein metabolic process | IEA | biological_process |
| GO:0030574 | collagen catabolic process | IEA | biological_process |
| GO:0008237 | metallopeptidase activity | IEA | molecular_function |
| GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | extracellular space | TAS | cellular_component |
| GO:0004222 | metalloendopeptidase activity | IEA | molecular_function |
| GO:0030198 | extracellular matrix organization | TAS | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0031012 | extracellular matrix | IEA | cellular_component |
| GO:0008233 | peptidase activity | IEA | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0030282 | bone mineralization | IEA | biological_process |