Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IC1_HUMAN
Description:serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 [Source:HGNC Symbol;Acc:1228]
Location:chr11 q12.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S296NAIYLsAKWKTSerpinPhosphoSitePlus
Y294LLNAIyLSAKWSerpinPhosphoSitePlus
S198LESILsYPKDFSerpinPhosphoSitePlus

Dephosphorylation site
IC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000278407D337NBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000278407A46TCOSMICCentral Nervous System Neoplasms18772396
ENSP00000278407K415*BIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
IC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IC1_HUMANLRP1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades
hsa05133Pertussis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002576platelet degranulationTASbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0045087innate immune responseIEAbiological_process
GO:0008233peptidase activityIEAmolecular_function
GO:0001869negative regulation of complement activation, lectIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0008015blood circulationTASbiological_process
GO:0006958complement activation, classical pathwayIEAbiological_process
GO:0042730fibrinolysisIEAbiological_process
GO:0010951negative regulation of endopeptidase activityIBAbiological_process
GO:0004867serine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0007597blood coagulation, intrinsic pathwayTASbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030168platelet activationTASbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component


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