| UniProt/SwissProt ID: | SPRE1_HUMAN |
| Description: | sprouty-related, EVH1 domain containing 1 [Source:HGNC Symbol;Acc:20249] |
| Location: | chr15 q14 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S8 | EETATsDNDNS | HPRD | |
| Y337 | RSRCVyCQERF | Sprouty | PhosphoSitePlus |
| Y211 | SRSMEyVQRQI | PhosphoSitePlus | |
| Y168 | VTSEPyRSSNI | PhosphoSitePlus | |
| Y292 | SKKSDyLYSCG | PhosphoSitePlus | |
| T5 | _MSEEtATSDN | PhosphoSitePlus | |
| Y294 | KSDYLySCGDE | PhosphoSitePlus | |
| S238 | SIRHVsFQDED | PhosphoSitePlus; HPRD | |
| Y82 | KKDLIyNKVTP | WH1 | PhosphoSitePlus |
| T7 | DNDN | HPRD | |
| T5 | TSDN | HPRD | |
| S2 | ____MsEETAT | PhosphoSitePlus | |
| Dephosphorylation site |
| SPRE1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000299084 | D274A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000299084 | R273I | COSMIC | Lung Cancer | 20668451 | ENSP00000299084 | E328* | COSMIC | Lung Cancer | 20668451 | ENSP00000299084 | S27* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000299084 | D274A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000299084 | Q50* | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| SPRE1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SPRE1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KIT_HUMAN | SPRE1_HUMAN | kinase -> substrate | NetPath |
| SOS1_HUMAN | SPRE1_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009966 | regulation of signal transduction | IEA | biological_process |
| GO:0010923 | negative regulation of phosphatase activity | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0043517 | positive regulation of DNA damage response, signal | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0090311 | regulation of protein deacetylation | IEA | biological_process |
| GO:0005173 | stem cell factor receptor binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0010801 | negative regulation of peptidyl-threonine phosphor | IEA | biological_process |
| GO:0000188 | inactivation of MAPK activity | IEA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005901 | caveola | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0019902 | phosphatase binding | IDA | molecular_function |
| GO:0030291 | protein serine/threonine kinase inhibitor activity | IEA | molecular_function |
| GO:0007275 | multicellular organismal development | IEA | biological_process |