| UniProt/SwissProt ID: | SPRE2_HUMAN |
| Description: | sprouty-related, EVH1 domain containing 2 [Source:HGNC Symbol;Acc:17722] |
| Location: | chr2 p14 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y266 | KHDYNyPYVDS | PhosphoSitePlus | |
| S168 | TRTISsPTSCE | PhosphoSitePlus | |
| Y231 | TGYEDyRHAPV | PhosphoSitePlus | |
| Y268 | DYNYPyVDSSD | PhosphoSitePlus | |
| Y228 | IWMTGyEDYRH | PhosphoSitePlus | |
| S167 | PTRTIsSPTSC | PhosphoSitePlus | |
| S297 | PSRGKsRRRKE | PhosphoSitePlus | |
| S206 | PYRQVsFPDDD | PhosphoSitePlus; HPRD | |
| S250 | EDADSsYVRFA | PhosphoSitePlus | |
| S249 | SEDADsSYVRF | PhosphoSitePlus | |
| Y251 | DADSSyVRFAK | PhosphoSitePlus | |
| Dephosphorylation site |
| SPRE2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000348753 | D9N | COSMIC | Lung Cancer | 20668451 | ENSP00000348753 | A388V | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000348753 | V19E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000348753 | S272* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000348753 | H352Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000348753 | S129P | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| SPRE2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SPRE2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KIT_HUMAN | SPRE2_HUMAN | kinase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | ISS | biological_process |
| GO:0005173 | stem cell factor receptor binding | IEA | molecular_function |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0031410 | cytoplasmic vesicle | IEA | cellular_component |
| GO:0030658 | transport vesicle membrane | IEA | cellular_component |
| GO:0005173 | stem cell factor receptor binding | ISS | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0043517 | positive regulation of DNA damage response, signal | ISS | biological_process |
| GO:0009966 | regulation of signal transduction | IEA | biological_process |
| GO:0010801 | negative regulation of peptidyl-threonine phosphor | IEA | biological_process |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0000188 | inactivation of MAPK activity | IEA | biological_process |
| GO:0043517 | positive regulation of DNA damage response, signal | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0090311 | regulation of protein deacetylation | ISS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0090311 | regulation of protein deacetylation | IEA | biological_process |
| GO:0030291 | protein serine/threonine kinase inhibitor activity | IEA | molecular_function |
| GO:0030291 | protein serine/threonine kinase inhibitor activity | ISS | molecular_function |
| GO:0010801 | negative regulation of peptidyl-threonine phosphor | IMP | biological_process |