Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCL5_HUMAN
Description:chemokine (C-C motif) ligand 5 [Source:HGNC Symbol;Acc:10632]
Location:chr17 q12
Node attribute:PPI(target); PPI(source); ligand; gene

Phosphorylation site
CCL5_HUMAN do not have phosphorylation site.

Dephosphorylation site
CCL5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000293272M90IBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CCL5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCL5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCL5_HUMANCCR3_HUMANligand -> receptorHPMR
CCL5_HUMANCCR5_HUMANligand -> receptorHPMR
CCL5_HUMANCCR3_HUMANotherKEGG
IRF5_HUMANCCL5_HUMANotherKEGG
NFKB1_HUMANCCL5_HUMANotherKEGG
FOS_HUMANCCL5_HUMANotherKEGG
CCL5_HUMANCCR5_HUMANotherKEGG
CCL5_HUMANCCR1_HUMANotherKEGG
NFKB1_HUMANCCL5_HUMANTF -> target geneKEGG
ATF2_HUMANCCL5_HUMANTF -> target geneTRANSFAC
IRF1_HUMANCCL5_HUMANTF -> target geneTRANSFAC
KLF13_HUMANCCL5_HUMANTF -> target geneTRANSFAC
CREB1_HUMANCCL5_HUMANTF -> target geneTRANSFAC
CEBPB_HUMANCCL5_HUMANTF -> target geneTRANSFAC
IRF7_HUMANCCL5_HUMANTF -> target geneTRANSFAC
TF65_HUMANCCL5_HUMANTF -> target geneTRANSFAC
CEBPD_HUMANCCL5_HUMANTF -> target geneTRANSFAC
JUN_HUMANCCL5_HUMANTF -> target geneTRANSFAC
IRF3_HUMANCCL5_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05020Prion diseases
hsa05142Chagas disease (American trypanosomiasis)
hsa04621NOD-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04062Chemokine signaling pathway
hsa05323Rheumatoid arthritis
hsa04060Cytokine-cytokine receptor interaction
hsa05164Influenza A
hsa04620Toll-like receptor signaling pathway
hsa05168Herpes simplex infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042531positive regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0002407dendritic cell chemotaxisTASbiological_process
GO:0050918positive chemotaxisIDAbiological_process
GO:0043491protein kinase B signaling cascadeIMPbiological_process
GO:0031726CCR1 chemokine receptor bindingIPImolecular_function
GO:0042102positive regulation of T cell proliferationIDAbiological_process
GO:0002676regulation of chronic inflammatory responseTASbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0045744negative regulation of G-protein coupled receptor IDAbiological_process
GO:0071407cellular response to organic cyclic compoundIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031663lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0045089positive regulation of innate immune responseTASbiological_process
GO:0051262protein tetramerizationIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0004435phosphatidylinositol phospholipase C activityIDAmolecular_function
GO:0010535positive regulation of activation of JAK2 kinase aTASbiological_process
GO:0043623cellular protein complex assemblyIDAbiological_process
GO:0071347cellular response to interleukin-1IEPbiological_process
GO:0045785positive regulation of cell adhesionIDAbiological_process
GO:0046817chemokine receptor antagonist activityIDAmolecular_function
GO:0031730CCR5 chemokine receptor bindingIPImolecular_function
GO:0031726CCR1 chemokine receptor bindingIEAmolecular_function
GO:0006954inflammatory responseIDAbiological_process
GO:0045070positive regulation of viral genome replicationTASbiological_process
GO:0070100negative regulation of chemokine-mediated signalinIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0014911positive regulation of smooth muscle cell migratioIDAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0042056chemoattractant activityIDAmolecular_function
GO:0070234positive regulation of T cell apoptotic processIDAbiological_process
GO:0071356cellular response to tumor necrosis factorIEPbiological_process
GO:0006874cellular calcium ion homeostasisIDAbiological_process
GO:0071346cellular response to interferon-gammaIEPbiological_process
GO:0042327positive regulation of phosphorylationIDAbiological_process
GO:0090026positive regulation of monocyte chemotaxisIEAbiological_process
GO:0042379chemokine receptor bindingIPImolecular_function
GO:0006935chemotaxisNASbiological_process
GO:0010759positive regulation of macrophage chemotaxisIDAbiological_process
GO:0050863regulation of T cell activationIDAbiological_process
GO:0030298receptor signaling protein tyrosine kinase activatIDAmolecular_function
GO:0031328positive regulation of cellular biosynthetic proceIDAbiological_process
GO:0034612response to tumor necrosis factorIEAbiological_process
GO:0009615response to virusTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0043922negative regulation by host of viral transcriptionIDAbiological_process
GO:0042119neutrophil activationIDAbiological_process
GO:0043621protein self-associationIDAmolecular_function
GO:0006887exocytosisIDAbiological_process
GO:0031729CCR4 chemokine receptor bindingTASmolecular_function
GO:0048661positive regulation of smooth muscle cell proliferIDAbiological_process
GO:0009636response to toxinIDAbiological_process
GO:0008009chemokine activityIDAmolecular_function
GO:0046427positive regulation of JAK-STAT cascadeTASbiological_process
GO:0090026positive regulation of monocyte chemotaxisIDAbiological_process
GO:0051928positive regulation of calcium ion transportIDAbiological_process
GO:0007267cell-cell signalingIDAbiological_process
GO:0010820positive regulation of T cell chemotaxisIDAbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0031584activation of phospholipase D activityIDAbiological_process
GO:0048245eosinophil chemotaxisIDAbiological_process
GO:0070098chemokine-mediated signaling pathwayTASbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0045071negative regulation of viral genome replicationIDAbiological_process
GO:0007159leukocyte cell-cell adhesionIDAbiological_process
GO:0034112positive regulation of homotypic cell-cell adhesioIDAbiological_process
GO:0016004phospholipase activator activityIDAmolecular_function
GO:0014068positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0070233negative regulation of T cell apoptotic processIDAbiological_process
GO:0033634positive regulation of cell-cell adhesion mediatedIDAbiological_process
GO:0006816calcium ion transportIDAbiological_process
GO:0000165MAPK cascadeIMPbiological_process
GO:0002548monocyte chemotaxisICbiological_process
GO:0045948positive regulation of translational initiationNASbiological_process
GO:2000503positive regulation of natural killer cell chemotaIDAbiological_process
GO:0044344cellular response to fibroblast growth factor stimIEPbiological_process
GO:2000110negative regulation of macrophage apoptotic procesIEAbiological_process
GO:0006955immune responseIEAbiological_process
GO:0048246macrophage chemotaxisTASbiological_process