| UniProt/SwissProt ID: | TREX1_HUMAN |
| Description: | three prime repair exonuclease 1 [Source:HGNC Symbol;Acc:12269] |
| Location: | chr3 p21.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S222 | LERASsPSEHG | HPRD; phosphoELM | |
| S261 | TTRNTsPSLGE | HPRD | |
| Y238 | SLGSIyTRLYG | RNase_T | PhosphoSitePlus |
| S78 | PGKACsPAASE | HPRD | |
| S133 | PGKACsPAASE | RNase_T | PhosphoSitePlus |
| S316 | TTRNTsPSLGE | PhosphoSitePlus; HPRD; phosphoELM | |
| S167 | LERASsPSEHG | HPRD | |
| S133 | PGKACsPAASE | HPRD; phosphoELM | |
| Dephosphorylation site |
| TREX1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000296443 | D102N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000390478 | G235S | COSMIC | Skin Cancer | 21984974 | ENSP00000415972 | D92N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000390478 | K121M | COSMIC | Skin Cancer | 21984974 | ENSP00000392569 | D102N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000390478 | K121* | COSMIC | Skin Cancer | 21984974 | ENSP00000390478 | D157N | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| TREX1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TREX1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ATR_HUMAN | TREX1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04623 | Cytosolic DNA-sensing pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032407 | MutSalpha complex binding | IDA | molecular_function |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0046872 | metal ion binding | NAS | molecular_function |
| GO:0008296 | 3'-5'-exodeoxyribonuclease activity | TAS | molecular_function |
| GO:0006298 | mismatch repair | NAS | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0003697 | single-stranded DNA binding | IEA | molecular_function |
| GO:0003690 | double-stranded DNA binding | IEA | molecular_function |
| GO:0008219 | cell death | IEA | biological_process |
| GO:0035458 | cellular response to interferon-beta | IEA | biological_process |
| GO:0005635 | nuclear envelope | NAS | cellular_component |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0006260 | DNA replication | NAS | biological_process |
| GO:0008853 | exodeoxyribonuclease III activity | IEA | molecular_function |
| GO:0008408 | 3'-5' exonuclease activity | IDA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0004527 | exonuclease activity | IEA | molecular_function |
| GO:0032558 | adenyl deoxyribonucleotide binding | IEA | molecular_function |
| GO:0006310 | DNA recombination | NAS | biological_process |
| GO:0032405 | MutLalpha complex binding | IDA | molecular_function |