| UniProt/SwissProt ID: | E2F3_HUMAN |
| Description: | E2F transcription factor 3 [Source:HGNC Symbol;Acc:3115] |
| Location: | chr6 p22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T169 | PDSPKtPKSPS | PhosphoSitePlus | |
| S124 | LGRGGsGGGGG | PhosphoSitePlus | |
| S172 | PKTPKsPSEKT | PhosphoSitePlus | |
| Y349 | GPIEVyLCPEE | PhosphoSitePlus | |
| S166 | LRSPDsPKTPK | PhosphoSitePlus | |
| T152 | SDGLKtPKGKG | PhosphoSitePlus | |
| S174 | TPKSPsEKTRY | PhosphoSitePlus | |
| Y179 | SEKTRyDTSLG | phosphoELM | |
| S182 | TRYDTsLGLLT | phosphoELM | |
| S163 | RAALRsPDSPK | PhosphoSitePlus | |
| Dephosphorylation site |
| E2F3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000262904 | G184C | COSMIC | Lung Cancer | |
| Differential expressed protein |
| E2F3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| E2F3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ACVR1_HUMAN | E2F3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| E2F3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0000085 | G2 phase of mitotic cell cycle | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0000080 | G1 phase of mitotic cell cycle | TAS | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0001047 | core promoter binding | IDA | molecular_function |
| GO:0008284 | positive regulation of cell proliferation | IEA | biological_process |