| UniProt/SwissProt ID: | GA45A_HUMAN |
| Description: | growth arrest and DNA-damage-inducible, alpha [Source:HGNC Symbol;Acc:4095] |
| Location: | chr1 p31.3 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S32 | LSKALsQRTIT | Ribosomal_L7Ae | PhosphoSitePlus |
| Y41 | ITVGVyEAAKL | Ribosomal_L7Ae | PhosphoSitePlus |
| Dephosphorylation site |
| GA45A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000360025 | E100G | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| GA45A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GA45A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK01_HUMAN | GA45A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| LATS1_HUMAN | GA45A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | GA45A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ACVR1_HUMAN | GA45A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TOPK_HUMAN | GA45A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| P53_HUMAN | GA45A_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| GA45A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0071479 | cellular response to ionizing radiation | IMP | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0007050 | cell cycle arrest | IEA | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0007098 | centrosome cycle | IEA | biological_process |
| GO:0071260 | cellular response to mechanical stimulus | IEP | biological_process |
| GO:2000379 | positive regulation of reactive oxygen species met | IMP | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0000079 | regulation of cyclin-dependent protein kinase acti | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006469 | negative regulation of protein kinase activity | IEA | biological_process |
| GO:0051726 | regulation of cell cycle | IEA | biological_process |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0042770 | signal transduction in response to DNA damage | IMP | biological_process |