Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACK1_HUMAN
Description:tyrosine kinase, non-receptor, 2 [Source:HGNC Symbol;Acc:19297]
Location:chr3 q29
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S856GKKVSsTHYYLPhosphoSitePlus
S165TFRKTsPAPGGHPRD
T925KANFStNNSNPPhosphoSitePlus
Y938SSTHYyLLPERHPRD
Y937VSSTHyYLLPEHPRD
Y518VKKPTyDPVSEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T465NSFIHtGHGDSGTPase_bindingPhosphoSitePlus
Y868PERPSyLERYQPhosphoSitePlus
Y284QNDDHyVMQEHTNK2phosphoELM
Y284QNDDHyVMQEHHPRD; RegPhos
S855DGKKVsSTHYYPhosphoSitePlus
T603SLLDEtPPQSPPhosphoSitePlus
Y857VSSTHyYLLPEphosphoELM; RegPhos
Y347QNDDHyVMQEHHPRD
S730PAPSPsPGGDDPhosphoSitePlus; HPRD
S802QAPAGsPAPSPHPRD
S102TFRKTsPAPGGHPRD; phosphoELM
Y346PQNDDhYVMQEHPRD
S785PREPLsPQGSRHPRD
S881LREAQsPEEPTPhosphoSitePlus; HPRD
Y284QNDDHyVMQEHACK(TNK2RegPhos
Y635PPPPAyDDVAQPhosphoSitePlus
Y193NLIRLyGVVLTPkinase_TyrPhosphoSitePlus
Y905ASDPKyATPQVHPRD
Y936KVSSThYYLLPHPRD
Y283PQNDDhYVMQEHPRD
S810PRLSSsPGKTMInhibitor_Mig-6PhosphoSitePlus
T101STFRKtSPAPGPhosphoSitePlus; HPRD
Y347QNDDHyVMQEHFYNHPRD
Y827ASDPKyATPQVInhibitor_Mig-6PhosphoSitePlus
S728GSPAPsPSPGGPhosphoSitePlus; HPRD
Y859VSSTHyYLLPEPhosphoSitePlus; HPRD
S959LREAQsPEEPTHPRD
Y284QNDDHyVMQEHPkinase_TyrPhosphoSitePlus
S724QAPAGsPAPSPPhosphoSitePlus; HPRD
Y595FTQKPtYDPVSHPRD
S36NVTRLsHFEYVSAM_2PhosphoSitePlus
Y872SYLERyQRFLRPhosphoSitePlus
Y858SSTHYyLLPERphosphoELM; RegPhos
S808PAPSPsPGGDDHPRD
T857KKVSStHYYLLPhosphoSitePlus
S607ETPPQsPTRALPhosphoSitePlus
Y517GVKKPtYDPVSHPRD
Y827ASDPKyATPQVHPRD
Y858KVSSThYYLLPHPRD
Y596TQKPTyDPVSEHPRD
Y284QNDDHyVMQEHautocatalysisRegPhos
S863PREPLsPQGSRHPRD
S867LPERPsYLERYPhosphoSitePlus
T517GVKKPtYDPVSPhosphoSitePlus; HPRD
S785PREPLsPQGSRInhibitor_Mig-6PhosphoSitePlus
T818KTMPTtQSFASInhibitor_Mig-6PhosphoSitePlus
T164STFRKtSPAPGHPRD
S149EWDAPsGKTVSRegPhos
S806GSPAPsPSPGGHPRD
Y860SSTHYyLLPERPhosphoSitePlus; HPRD
S212LAPLGsLLDRLRegPhos
Y284QNDDHyVMQEHFYNHPRD; RegPhos
S149EWDAPsGKTVSPkinase_TyrPhosphoSitePlus
S74LCKRKsWMSKVPhosphoSitePlus
T595FTQKPtYDPVSHPRD
Y826ASDPKyATPQVphosphoELM; RegPhos
Y905PAAPTaTVRPMRegPhos

Dephosphorylation site
ACK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376201R34LHPILung Cancer17344846
ENSP00000323216*529WCOSMICMelanoma21499247
ENSP00000376201R99QHPIOvarian Cancer17344846
ENSP00000329425E346KHPIOvarian Cancer20333297 17344846 20110370
ENSP00000323216*529WCOSMICMelanoma21499247
ENSP00000395588*529WCOSMICMelanoma21499247
ENSP00000395588*529WCOSMICMelanoma21499247
ENSP00000371341T697MCOSMICOvarian Cancer21720365
ENSP00000329425R99QHPIOvarian Cancer17344846
ENSP00000329425M409IHPIGastric Cancer17344846
ENSP00000376201M409IHPIGastric Cancer17344846
ENSP00000376201E346KHPIOvarian Cancer20333297 17344846 20110370
ENSP00000329425R34LHPILung Cancer17344846
ENSP00000371341A50TCOSMICCentral Nervous System Neoplasms
ENSP00000371341R829GDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000371341R445WCOSMICGastric Cancer21097718

Differential expressed protein
ACK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y284Pkinase_TyrLPQNDDHyVMQEHRKbreast cancer20333297PhosphoSitePlus
Y284Pkinase_TyrLPQNDDHyVMQEHRKprostate cancer20623637PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ACK1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANRET_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANACK1_HUMANkinase -> substrateHPRD; RegPhos
ACK1_HUMANKC1G2_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANACK1_HUMANkinase -> substrateRegPhos
ACK1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANKCC2A_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANGRK5_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ACK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005768endosomeISScellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:2000369regulation of clathrin-mediated endocytosisIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006897endocytosisIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0030424axonIEAcellular_component
GO:0005905coated pitIDAcellular_component
GO:0030659cytoplasmic vesicle membraneIEAcellular_component
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0030426growth coneIEAcellular_component
GO:0016310phosphorylationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004712protein serine/threonine/tyrosine kinase activityIDAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005095GTPase inhibitor activityTASmolecular_function
GO:0070436Grb2-EGFR complexIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0050699WW domain bindingISSmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005912adherens junctionIEAcellular_component
GO:0030136clathrin-coated vesicleIDAcellular_component
GO:0005154epidermal growth factor receptor bindingIDAmolecular_function


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