Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VHL_HUMAN
Description:von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:12687]
Location:chr3 p25.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S38SGAEEsGPEESPhosphoSitePlus
S72NSREPsQVIFCVHLPhosphoSitePlus
Y112RRIHSyRGHLWPhosphoSitePlus
T105TLPPGtGRRIHVHLPhosphoSitePlus
T202DLERLtQERIAPhosphoSitePlus
S43SGPEEsGPEELPhosphoSitePlus
S183LDIVRsLYEDLVHLPhosphoSitePlus
Y175VKPENyRRLDIPhosphoSitePlus
Y185IVRSLyEDLEDVHLPhosphoSitePlus
S111GRRIHsYRGHLVHLPhosphoSitePlus
S68LRSVNsREPSQVHLPhosphoSitePlus
S33DGGEEsGAEESPhosphoSitePlus
T100PQPYPtLPPGTPhosphoSitePlus
S168LQVVRsLVKPEPhosphoSitePlus

Dephosphorylation site
VHL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000256474A122ECOSMICRenal Cancer10766184
ENSP00000256474L169*COSMICRenal Cancer11921283
ENSP00000256474D92fs*67COSMICRenal Cancer11505222
ENSP00000256474Q195RCOSMICRenal Cancer11536052
ENSP00000256474A50TCOSMICRenal Cancer10454237
ENSP00000256474R60WCOSMICRenal Cancer11536052
ENSP00000256474S65fs*2COSMICRenal Cancer9143408
ENSP00000256474G44DCOSMICRenal Cancer11536052
ENSP00000256474*214CCOSMICNeoplasms by Histologic Type12673678
ENSP00000256474F91fs*68COSMICRenal Cancer19755989
ENSP00000256474R182KCOSMICIntestines Cancer14965365
ENSP00000256474I109fs*50COSMICRenal Cancer15932632
ENSP00000256474V137fs*22COSMICRenal Cancer20054297
ENSP00000256474F91LCOSMICRenal Cancer15177666
ENSP00000256474P86HCOSMICRenal Cancer7915601
ENSP00000256474V130fs*29COSMICRenal Cancer11505222
ENSP00000256474S65LCOSMICRenal Cancer7915601
ENSP00000256474*214YCOSMICOvarian Cancer21720365
ENSP00000256474G114SCOSMICRenal Cancer7915601
ENSP00000256474E70fs*89COSMICRenal Cancer19996202
ENSP00000256474E12KDing2008Lung Cancer11793370, 18428421, 18948947
ENSP00000256474V155fs*4COSMICRenal Cancer11921283
ENSP00000256474L198PCOSMICNeoplasms by Histologic Type12673678
ENSP00000256474T124fs*35COSMICRenal Cancer16488999
ENSP00000256474Q96fs*63COSMICRenal Cancer19755989
ENSP00000256474E41VCOSMICRenal Cancer15932632
ENSP00000256474R167fs*3COSMICRenal Cancer11505222
ENSP00000256474L135FOMIM, COSMICNeoplasms by Histologic Type8069849
ENSP00000256474Q73fs*86COSMICRenal Cancer16488999
ENSP00000256474S183fs*19COSMICRenal Cancer15932632
ENSP00000256474E186*COSMICRenal Cancer20054297
ENSP00000256474V155MCOSMICRenal Cancer20054297
ENSP00000256474T105fs*54COSMICRenal Cancer11793370
ENSP00000256474F136fs*23COSMICRenal Cancer16488999
ENSP00000256474C77SCOSMICRenal Cancer10925357
ENSP00000256474W8*COSMICRenal Cancer11536052
ENSP00000256474L116VCOSMICRenal Cancer11505222
ENSP00000256474R79fs*80COSMICRenal Cancer11921283
ENSP00000256474H125fs*34COSMICRenal Cancer16488999
ENSP00000256474E12KDing2008, COSMICRenal Cancer11793370, 18428421, 18948947
ENSP00000256474Q132*COSMICRenal Cancer20054297
ENSP00000256474V170DCOSMICRenal Cancer16488999
ENSP00000256474E189KCOSMICRenal Cancer11921283
ENSP00000256474W117*COSMICRenal Cancer7915601
ENSP00000256474N90ICOSMICRenal Cancer7915601
ENSP00000256474S72fs*87COSMICRenal Cancer20054297
ENSP00000256474N131fs*28COSMICRenal Cancer20054297
ENSP00000256474G49DCOSMICRenal Cancer11536052
ENSP00000256474W117fs*42COSMICRenal Cancer16488999
ENSP00000256474I180fs*22COSMICRenal Cancer7915601
ENSP00000256474F136VCOSMICRenal Cancer20054297
ENSP00000256474N174DCOSMICRenal Cancer11793370
ENSP00000256474R82fs*77COSMICRenal Cancer8187067
ENSP00000256474S68PCOSMICRenal Cancer20054297
ENSP00000256474F148SCOSMICRenal Cancer15932632
ENSP00000256474W88*COSMICRenal Cancer11505222
ENSP00000256474A56fs*11COSMICRenal Cancer20054297
ENSP00000256474E37KCOSMICRenal Cancer10454237
ENSP00000256474E10GCOSMICRenal Cancer11793370
ENSP00000256474Q96*COSMICRenal Cancer12853836
ENSP00000256474D197fs*5COSMICRenal Cancer20054297
ENSP00000256474P59fs*8COSMICRenal Cancer20054297
ENSP00000256474D126fs*33COSMICRenal Cancer10766184
ENSP00000256474D187fs*15COSMICRenal Cancer19996202
ENSP00000256474W88fs*71COSMICUterine Cancer18552176
ENSP00000256474E55fs*12COSMICRenal Cancer11505222
ENSP00000256474R113*COSMICRenal Cancer20054297
ENSP00000256474Y175DCOSMICRenal Cancer20054297
ENSP00000256474L153PCOSMICRenal Cancer8871925
ENSP00000256474L178fs*24COSMICRenal Cancer16488999
ENSP00000256474P192LCOSMICRenal Cancer11793370
ENSP00000256474T105PCOSMICRenal Cancer11505222
ENSP00000256474P154fs*5COSMICRenal Cancer19755989
ENSP00000256474R120*COSMICRenal Cancer11051223
ENSP00000256474G144*COSMICRenal Cancer20054297
ENSP00000256474D92NCOSMICRenal Cancer9143408
ENSP00000256474G106DHPI, COSMICLung Cancer, 8183553
ENSP00000256474L128fs*31COSMICRenal Cancer7915601
ENSP00000256474S168fs*2COSMICRenal Cancer20054297
ENSP00000256474R176fs*25COSMICRenal Cancer21248752
ENSP00000256474F119LCOSMICRenal Cancer10340905
ENSP00000256474L158fs*1COSMICRenal Cancer11505222
ENSP00000256474E42VCOSMICRenal Cancer15932632
ENSP00000256474P146ACOSMICRenal Cancer19755989
ENSP00000256474W88SOMIMNeoplasms by Histologic Type7784063 8069849
ENSP00000256474P81fs*78COSMICRenal Cancer7881415
ENSP00000256474V62fs*5COSMICRenal Cancer16488999
ENSP00000256474L135fs*24COSMICRenal Cancer7915601
ENSP00000256474M1ICOSMICRenal Cancer11505222
ENSP00000256474A11TCOSMICRenal Cancer19933033
ENSP00000256474D190fs*12COSMICRenal Cancer10340905
ENSP00000256474R161*COSMICRenal Cancer20054297
ENSP00000256474Y185fs*17COSMICRenal Cancer11921283
ENSP00000256474E189fs*13COSMICRenal Cancer9143408
ENSP00000256474E51QCOSMICRenal Cancer15932632
ENSP00000256474E94*COSMICRenal Cancer20054297
ENSP00000256474G93SCOSMICNeoplasms by Histologic Type8768845
ENSP00000256474P138RCOSMICRenal Cancer7915601
ENSP00000256474H110PCOSMICRenal Cancer
ENSP00000256474M211ICOSMICRenal Cancer11793370
ENSP00000256474E134ACOSMICRenal Cancer11921283
ENSP00000256474C77*COSMICRenal Cancer10925357
ENSP00000256474T133fs*26COSMICRenal Cancer10766184
ENSP00000256474F119fs*40COSMICRenal Cancer11536052
ENSP00000256474P81SCOSMICRenal Cancer10340905
ENSP00000256474V142fs*17COSMICRenal Cancer16488999
ENSP00000256474R107fs*52COSMICRenal Cancer20054297
ENSP00000256474R69fs*90COSMICRenal Cancer15932632
ENSP00000256474L188PCOSMICRenal Cancer20054297
ENSP00000256474N7TCOSMICNeoplasms by Histologic Type12405390
ENSP00000256474D179fs*23COSMICRenal Cancer9143408
ENSP00000256474G93fs*66COSMICRenal Cancer11921283
ENSP00000256474L101PCOSMICRenal Cancer16488999
ENSP00000256474V130LCOSMICRenal Cancer7915601
ENSP00000256474E70*COSMICRenal Cancer16488999
ENSP00000256474Q164*COSMICRenal Cancer7915601
ENSP00000256474V74fs*85COSMICRenal Cancer20054297
ENSP00000256474W117RCOSMICRenal Cancer7915601
ENSP00000256474I151fs*8COSMICRenal Cancer12115316
ENSP00000256474Q73*COSMICRenal Cancer20054297
ENSP00000256474D126GCOSMICRenal Cancer8871925
ENSP00000256474T157fs*2COSMICRenal Cancer7915601
ENSP00000256474V166DCOSMICRenal Cancer20054297
ENSP00000256474D28VCOSMICRenal Cancer11793370
ENSP00000256474T157ICOSMICRenal Cancer15809750
ENSP00000256474E204GCOSMICRenal Cancer11793370
ENSP00000256474L178RCOSMICRenal Cancer11051223
ENSP00000256474I147fs*12COSMICRenal Cancer10766184
ENSP00000256474H115YCOSMICRenal Cancer7915601
ENSP00000256474L169PCOSMICRenal Cancer20054297
ENSP00000256474L135*COSMICRenal Cancer20054297
ENSP00000256474N67SCOSMICRenal Cancer12781449
ENSP00000256474S68*COSMICRenal Cancer7915601
ENSP00000256474P146fs*13COSMICRenal Cancer7881415
ENSP00000256474L63fs*4COSMICNeoplasms by Histologic Type12405390
ENSP00000256474L85fs*74COSMICRenal Cancer11505222
ENSP00000256474G57ECOSMICNeoplasms by Histologic Type12673678
ENSP00000256474N78KCOSMICRenal Cancer20054297
ENSP00000256474I180NCOSMICRenal Cancer10454237
ENSP00000256474L153fs*6COSMICRenal Cancer11793370
ENSP00000256474Y98*COSMICRenal Cancer20054297
ENSP00000256474Q209*COSMICRenal Cancer11536052
ENSP00000256474R210WCOSMICCentral Nervous System Neoplasms9067265
ENSP00000256474N193fs*9COSMICRenal Cancer7881415
ENSP00000256474S111GCOSMICRenal Cancer21258414
ENSP00000256474D187VCOSMICRenal Cancer11051223
ENSP00000256474E160*COSMICRenal Cancer7977367
ENSP00000256474L116fs*43COSMICRenal Cancer10766184
ENSP00000256474Q164RCOSMICNeoplasms by Histologic Type8825918
ENSP00000256474E134*COSMICRenal Cancer16488999
ENSP00000256474L184PCOSMICRenal Cancer20054297
ENSP00000256474F76YCOSMICRenal Cancer10925357
ENSP00000256474D143ECOSMICNeoplasms by Histologic Type8825918
ENSP00000256474N67fs*92COSMICRenal Cancer19996202
ENSP00000256474H110fs*49COSMICRenal Cancer11505222
ENSP00000256474A5fs*9COSMICLymphoma11085513
ENSP00000256474N141fs*18COSMICRenal Cancer11505222
ENSP00000256474P172fs*30COSMICRenal Cancer20054297
ENSP00000256474L163POMIM, COSMIC, HPIRenal Cancer11986208
ENSP00000256474L85PCOSMICRenal Cancer15809750
ENSP00000256474R167WCOSMICRenal Cancer7915601
ENSP00000256474Q203fs*11COSMICRenal Cancer7915601
ENSP00000256474Q195*COSMICRenal Cancer20054297
ENSP00000256474N78fs*81COSMICRenal Cancer11536052
ENSP00000256474P40SCOSMICRenal Cancer10454237
ENSP00000256474V165ICOSMICRenal Cancer16488999
ENSP00000256474A149PCOSMICRenal Cancer7881415
ENSP00000256474N131YCOSMICRenal Cancer15932632
ENSP00000256474L140fs*19COSMICRenal Cancer7915601
ENSP00000256474Y156fs*3COSMICRenal Cancer17067398
ENSP00000256474L158PCOSMICRenal Cancer7915601
ENSP00000256474R69CCOSMICRenal Cancer10340905
ENSP00000256474A207VCOSMICCentral Nervous System Neoplasms9067265
ENSP00000256474Y112fs*47COSMICRenal Cancer15932632
ENSP00000256474P103fs*56COSMICRenal Cancer11921283
ENSP00000256474V87fs*72COSMICRenal Cancer20054297
ENSP00000256474N174fs*28COSMICRenal Cancer10454237
ENSP00000256474E31GCOSMICRenal Cancer11793370
ENSP00000256474G114fs*45COSMICRenal Cancer10766184
ENSP00000256474Y156DCOSMICRenal Cancer11967908
ENSP00000256474P25SCOSMICRenal Cancer11536052
ENSP00000256474Y112DCOSMICRenal Cancer15932632
ENSP00000256474L128PCOSMICRenal Cancer20054297
ENSP00000256474L163fs*7COSMICRenal Cancer7915601
ENSP00000256474Y98NCOSMICRenal Cancer7915601
ENSP00000256474E160fs*10COSMICRenal Cancer15932632
ENSP00000256474Y185*COSMICRenal Cancer7977367
ENSP00000256474P99fs*60COSMICRenal Cancer20054297
ENSP00000256474R177fs*25COSMICRenal Cancer11505222
ENSP00000256474F148fs*11COSMICRenal Cancer20054297
ENSP00000256474V165fs*5COSMICRenal Cancer11793370
ENSP00000256474R200WCOSMICRenal Cancer10340905
ENSP00000256474I151SCOSMICRenal Cancer7915601
ENSP00000256474P192fs*10COSMICRenal Cancer
ENSP00000256474F76fs*83COSMICRenal Cancer15932632
ENSP00000256474R58fs*9COSMICRenal Cancer
ENSP00000256474K171NCOSMICRenal Cancer20054297
ENSP00000256474N90fs*69COSMICRenal Cancer11505222
ENSP00000256474L89HHPILung Cancer
ENSP00000256474S33ACOSMICRenal Cancer11967908
ENSP00000256474Y112*COSMICRenal Cancer20054297
ENSP00000256474G144fs*15COSMICRenal Cancer7915601
ENSP00000256474R176WCOSMICRenal Cancer11505222
ENSP00000256474L89HCOSMICRenal Cancer7915601
ENSP00000256474E134fs*25COSMICRenal Cancer20054297
ENSP00000256474T152fs*7COSMICRenal Cancer19755989
ENSP00000256474Q145HCOSMICRenal Cancer11505222
ENSP00000256474K196*COSMICRenal Cancer20054297
ENSP00000256474Y175fs*27COSMICRenal Cancer7915601
ENSP00000256474W88SCOSMICRenal Cancer20054297
ENSP00000256474S183*COSMICRenal Cancer7915601
ENSP00000256474R177*COSMICRenal Cancer7977367
ENSP00000256474T133SCOSMICRenal Cancer7881415
ENSP00000256474D121GCOSMICRenal Cancer20054297
ENSP00000256474G104fs*55COSMICRenal Cancer7915601
ENSP00000256474P95RCOSMICRenal Cancer15932632
ENSP00000256474R79HCOSMICRenal Cancer11536052
ENSP00000256474P102ACOSMICRenal Cancer15932632
ENSP00000256474T100ACOSMICRenal Cancer7591282
ENSP00000256474E160KCOSMICRenal Cancer11536052
ENSP00000256474R82PCOSMICRenal Cancer7915601
ENSP00000256474G39SCOSMICRenal Cancer11793370
ENSP00000256474C162YCOSMICRenal Cancer7915601
ENSP00000256474L188fs*14COSMICRenal Cancer11793370
ENSP00000256474V83ICOSMICRenal Cancer19933033
ENSP00000256474S65*COSMICRenal Cancer20054297
ENSP00000256474Y98fs*61COSMICRenal Cancer20054297
ENSP00000256474L48VCOSMICRenal Cancer15932632
ENSP00000256474P154LCOSMICRenal Cancer16488999
ENSP00000256474Q96HCOSMICRenal Cancer15932632
ENSP00000256474D143fs*16COSMICRenal Cancer7915601
ENSP00000256474Q132HCOSMICNeoplasms by Histologic Type9458097
ENSP00000256474L118PCOSMICRenal Cancer7915601
ENSP00000256474V170fs*32COSMICRenal Cancer20054297
ENSP00000256474Y175*COSMICRenal Cancer20054297
ENSP00000256474L169fs*33COSMICRenal Cancer19755989
ENSP00000256474S111fs*48COSMICRenal Cancer15932632
ENSP00000256474S38FCOSMICRenal Cancer15932632
ENSP00000256474G144ACOSMICNeoplasms by Histologic Type9458097
ENSP00000256474R108fs*51COSMICRenal Cancer10925357
ENSP00000256474E26KCOSMICRenal Cancer11793370
ENSP00000256474H115fs*44COSMICRenal Cancer11921283
ENSP00000256474N150fs*9COSMICRenal Cancer7915601
ENSP00000256474C162*COSMICRenal Cancer16488999
ENSP00000256474I109NCOSMICRenal Cancer20054297
ENSP00000256474R113fs*46COSMICRenal Cancer11051223
ENSP00000256474R120fs*39COSMICRenal Cancer7915601
ENSP00000256474P99LCOSMICRenal Cancer20054297
ENSP00000256474S139fs*20COSMICRenal Cancer20054297
ENSP00000256474V66fs*93COSMICRenal Cancer16488999
ENSP00000256474G106fs*53COSMICRenal Cancer11921283
ENSP00000256474D179ACOSMICIntestines Cancer14965365
ENSP00000256474R161QCOSMICNeoplasms by Histologic Type11174629
ENSP00000256474S80RCOSMICPancreatic Cancer11141506
ENSP00000256474V74DCOSMICRenal Cancer11051223
ENSP00000256474Y156*COSMICRenal Cancer19755989

Differential expressed protein
VHL_HUMAN is not differential expressed protein.

Hyperphosphorylation site
VHL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LCK_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
CLK1_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
M3K14_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
PRKY_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
STK25_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
STK16_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
VHL_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0061428negative regulation of transcription from RNA polyIDAbiological_process
GO:0006950response to stressNASbiological_process
GO:0050821protein stabilizationNASbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusTAScellular_component
GO:0043066negative regulation of apoptotic processNASbiological_process
GO:0016567protein ubiquitinationIMPbiological_process
GO:0071456cellular response to hypoxiaTASbiological_process
GO:0004842ubiquitin-protein ligase activityTASmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0000902cell morphogenesisNASbiological_process
GO:0045597positive regulation of cell differentiationNASbiological_process
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0005739mitochondrionNAScellular_component
GO:0016020membraneIEAcellular_component
GO:0033554cellular response to stressTASbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIMPbiological_process
GO:0006508proteolysisTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0061418regulation of transcription from RNA polymerase IITASbiological_process
GO:0005783endoplasmic reticulumNAScellular_component
GO:0005829cytosolTAScellular_component