Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SYWC_HUMAN
Description:tryptophanyl-tRNA synthetase [Source:HGNC Symbol;Acc:12729]
Location:chr14 q32.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S98RGIFFsHRDMNHPRD
T453RRKEVtDEIVKPhosphoSitePlus
S4__MPNsEPASLPhosphoSitePlus
S467TPRKLsFDHPRD; phosphoELM; SysPTM
S38KDEIDsAVKMLWHEP-TRSPhosphoSitePlus
Y316IDQDPyFRMTRtRNA-synt_1bPhosphoSitePlus
T259IQKHVtFNQVKtRNA-synt_1bPhosphoSitePlus
T259IQKHVtFNQVKHPRD
S4PASLHPRD
S426TPRKLsFDHPRD
T218IQKHVtFNQVKHPRD
S139RGIFFsHRDMNPhosphoSitePlus; HPRD
S467TPRKLsFDFQ_PhosphoSitePlus; SysPTM
S45VKMLVsLKMSYWHEP-TRSPhosphoSitePlus

Dephosphorylation site
SYWC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376620E455DSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000347495E455DSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000347495Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineUp1.517152098
ENSP00000347495Oral CancerNormal vs. CancertissueUp2419297561
ENSP00000347495Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.220804217
ENSP00000347495Breast CancerNormal vs. CancertissueUp2.620005186
ENSP00000347495Breast CancerNormal vs. CancertissueUp6.120005186
ENSP00000347495Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp3.616807943
ENSP00000347495Pancreatic CancerNormal vs. CancertissueUp215526344
ENSP00000347495Uterine CancerTreatment (Concurrent chemoradiotherapy-lowly vs. Concurrent chemoradiotherapy-highly sensitive)tissueDown19507834

Hyperphosphorylation site
SYWC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STA5A_HUMANSYWC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
SYWC_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010467gene expressionTASbiological_process
GO:0006436tryptophanyl-tRNA aminoacylationIEAbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0004830tryptophan-tRNA ligase activityIEAmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0004812aminoacyl-tRNA ligase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0045765regulation of angiogenesisIDAbiological_process
GO:0006412translationTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0006418tRNA aminoacylation for protein translationTASbiological_process
GO:0006418tRNA aminoacylation for protein translationIEAbiological_process


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