Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FCGR1_HUMAN
Description:Fc fragment of IgG, high affinity Ia, receptor (CD64) [Source:HGNC Symbol;Acc:3613]
Location:chrHG1287_PATCH q21.
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y138YNVLYyRNGKAigPhosphoSitePlus
Y133KDKLVyNVLYYHPRD; phosphoELM
Y133KDKLVyNVLYYigPhosphoSitePlus
Y138YNVLYyRNGKAHPRD; phosphoELM
Y137VYNVLyYRNGKigPhosphoSitePlus

Dephosphorylation site
FCGR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358165Y245HCOSMICOvarian Cancer21720365
ENSP00000358165Y245HTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
FCGR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FCGR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STA5A_HUMANFCGR1_HUMANTF -> target geneTRANSFAC
STAT6_HUMANFCGR1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
FCGR1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019770IgG receptor activityIEAmolecular_function
GO:0042742defense response to bacteriumIEAbiological_process
GO:0031901early endosome membraneTAScellular_component
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0005057receptor signaling protein activityTASmolecular_function
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0050766positive regulation of phagocytosisIEAbiological_process
GO:0030669clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0006911phagocytosis, engulfmentIEAbiological_process
GO:0006955immune responseTASbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0001805positive regulation of type III hypersensitivityIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0001798positive regulation of type IIa hypersensitivityIEAbiological_process
GO:0001788antibody-dependent cellular cytotoxicityIEAbiological_process
GO:0006910phagocytosis, recognitionIEAbiological_process
GO:0019864IgG bindingIEAmolecular_function
GO:0006898receptor-mediated endocytosisIEAbiological_process
GO:0005886plasma membraneIDAcellular_component


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