| UniProt/SwissProt ID: | RPGF2_HUMAN |
| Description: | Rap guanine nucleotide exchange factor (GEF) 2 [Source:HGNC Symbol;Acc:16854] |
| Location: | chr4 q32.1 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S583 | VSGTLsSSNPD | HPRD | |
| S276 | VIKGTsERLTM | RasGEF_N | PhosphoSitePlus |
| T387 | KRRLMtLTKPS | PDZ | PhosphoSitePlus |
| Y968 | NAKKLyEDAQM | PhosphoSitePlus | |
| S1116 | SSQLSsPPTSP | PhosphoSitePlus; HPRD; phosphoELM | |
| T1341 | DSEGDtGTIKR | PhosphoSitePlus | |
| S1089 | LKKILsLSEEG | HPRD | |
| T1343 | EGDTGtIKRRG | PhosphoSitePlus | |
| Y853 | RNMAKyRNVLN | RasGEF; DUF1944 | PhosphoSitePlus |
| T275 | IVIKGtSERLT | RasGEF_N | PhosphoSitePlus |
| S930 | KKKWRsLGSLS | PhosphoSitePlus | |
| S935 | SLGSLsQGSTN | PhosphoSitePlus; HPRD; phosphoELM | |
| S1022 | VKSETsPVAPR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T1119 | LSSPPtSPQSS | PhosphoSitePlus; HPRD; phosphoELM | |
| S960 | RVRRSsFLNAK | PhosphoSitePlus; HPRD | |
| S584 | SGTLSsSNPDL | HPRD | |
| S959 | KRVRRsSFLNA | HPRD | |
| Y500 | KKASRySIPDL | PhosphoSitePlus | |
| T602 | LDFSAtPDLPD | PhosphoSitePlus | |
| S1156 | RSSIVsNSSFD | PhosphoSitePlus | |
| T1006 | EPATNtLPKNP | PhosphoSitePlus | |
| S1337 | YWGEDsEGDTG | PhosphoSitePlus | |
| S859 | RNVLNsQNLQP | RasGEF; DUF1944 | PhosphoSitePlus |
| T387 | KRRLMtLTKPS | HPRD | |
| Dephosphorylation site |
| RPGF2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264431 | *1500W | COSMIC | Hepatocellular Carcinoma | ENSP00000264431 | K976E | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000264431 | I411V | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| RPGF2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RPGF2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RPGF2_HUMAN | RRAS2_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0051056 | regulation of small GTPase mediated signal transdu | IEA | biological_process |
| GO:0019933 | cAMP-mediated signaling | NAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0019992 | diacylglycerol binding | NAS | molecular_function |
| GO:0048167 | regulation of synaptic plasticity | IEA | biological_process |
| GO:0004871 | signal transducer activity | TAS | molecular_function |
| GO:0017034 | Rap guanyl-nucleotide exchange factor activity | IDA | molecular_function |
| GO:0016020 | membrane | IDA | cellular_component |
| GO:0005887 | integral to plasma membrane | NAS | cellular_component |
| GO:0032854 | positive regulation of Rap GTPase activity | IEA | biological_process |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0035556 | intracellular signal transduction | TAS | biological_process |
| GO:0046582 | Rap GTPase activator activity | IDA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005509 | calcium ion binding | NAS | molecular_function |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0000165 | MAPK cascade | NAS | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |