Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RPGF2_HUMAN
Description:Rap guanine nucleotide exchange factor (GEF) 2 [Source:HGNC Symbol;Acc:16854]
Location:chr4 q32.1
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S583VSGTLsSSNPDHPRD
S276VIKGTsERLTMRasGEF_NPhosphoSitePlus
T387KRRLMtLTKPSPDZPhosphoSitePlus
Y968NAKKLyEDAQMPhosphoSitePlus
S1116SSQLSsPPTSPPhosphoSitePlus; HPRD; phosphoELM
T1341DSEGDtGTIKRPhosphoSitePlus
S1089LKKILsLSEEGHPRD
T1343EGDTGtIKRRGPhosphoSitePlus
Y853RNMAKyRNVLNRasGEF; DUF1944PhosphoSitePlus
T275IVIKGtSERLTRasGEF_NPhosphoSitePlus
S930KKKWRsLGSLSPhosphoSitePlus
S935SLGSLsQGSTNPhosphoSitePlus; HPRD; phosphoELM
S1022VKSETsPVAPRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T1119LSSPPtSPQSSPhosphoSitePlus; HPRD; phosphoELM
S960RVRRSsFLNAKPhosphoSitePlus; HPRD
S584SGTLSsSNPDLHPRD
S959KRVRRsSFLNAHPRD
Y500KKASRySIPDLPhosphoSitePlus
T602LDFSAtPDLPDPhosphoSitePlus
S1156RSSIVsNSSFDPhosphoSitePlus
T1006EPATNtLPKNPPhosphoSitePlus
S1337YWGEDsEGDTGPhosphoSitePlus
S859RNVLNsQNLQPRasGEF; DUF1944PhosphoSitePlus
T387KRRLMtLTKPSHPRD

Dephosphorylation site
RPGF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264431*1500WCOSMICHepatocellular Carcinoma
ENSP00000264431K976EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000264431I411VBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
RPGF2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RPGF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RPGF2_HUMANRRAS2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionIEAbiological_process
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0019933cAMP-mediated signalingNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0019992diacylglycerol bindingNASmolecular_function
GO:0048167regulation of synaptic plasticityIEAbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0017034Rap guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0016020membraneIDAcellular_component
GO:0005887integral to plasma membraneNAScellular_component
GO:0032854positive regulation of Rap GTPase activityIEAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0035556intracellular signal transductionTASbiological_process
GO:0046582Rap GTPase activator activityIDAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0005509calcium ion bindingNASmolecular_function
GO:0005085guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0000165MAPK cascadeNASbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23