Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NF1_HUMAN
Description:neurofibromin 1 [Source:HGNC Symbol;Acc:7765]
Location:chr17 q11.2
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1521EKIGQyLSSNRPhosphoSitePlus
Y2476VPMDTyPIHHGPhosphoSitePlus; HPRD; phosphoELM
S2188RDRSFsPGSYEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S879KGSMIsVMSSEPhosphoSitePlus
T2444LAALLtVSEEVPhosphoSitePlus
Y863SGLATySPPMGPhosphoSitePlus
S2543LGTRKsFDHLIPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S2798RHGSAsQVQKQHPRD
S2819RHGSAsQVQKQPhosphoSitePlus; HPRD
S2502ARKSMsLDMGQHPRD
S2808QRSAGsFKRNSHPRD
Y2503KGSEGyLAATYPhosphoSitePlus
S56FSLVIsGLTTIHPRD
Y2455VPMDTyPIHHGHPRD
S2576HLRKVsVSESNHPRD
S2802ENVELsPTTGHHPRD
Y2577VAETDyEMETQPhosphoSitePlus; HPRD
S2515TVGQTsPRARKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S876SERKGsMISVMPhosphoSitePlus
S2523ARKSMsLDMGQPhosphoSitePlus; HPRD; phosphoELM
S2460LKHRKsLLLTDPhosphoSitePlus
T2507GYLAAtYPTVGHPRD
S2496TQPWSsPKGSEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S864GLATYsPPMGPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S2474ETQPWsSPKGSHPRD
Y2508YLAATyPTVGQPhosphoSitePlus; HPRD
T1435NHVLFtKEEHMHPRD
S2500PRARKsMSLDMHPRD
T1751LAHKDtKVSIKPhosphoSitePlus
T2486GYLAAtYPTVGHPRD
T915GLQIRtNVKDLPhosphoSitePlus
S2495ETQPWsSPKGSHPRD; phosphoELM
T60ISGLTtILKNVHPRD
S2597HLRKVsVSESNPhosphoSitePlus; HPRD
S2817RTRHGsASQVQPhosphoSitePlus; HPRD
S2522LGTRKsFDHLIHPRD
S2167RDRSFsPGSYEHPRD
T2493PTVGQtSPRARHPRD
S2834SFKRNsIKKIVPhosphoSitePlus
S2561RQEMEsGITTPPhosphoSitePlus
T1456NHVLFtKEEHMHPRD
Y930LSPALyPMLFNPhosphoSitePlus
Y2487YLAATyPTVGQHPRD
S2494TVGQTsPRARKHPRD
T2565ESGITtPPKMRPhosphoSitePlus
T676AGCSGtPPICRPhosphoSitePlus
Y2556VAETDyEMETQHPRD
T2581DYEMEtQRISSPhosphoSitePlus
S2446ALLTVsEEVRSPhosphoSitePlus
T2489AATYPtVGQTSHPRD
S465IRMAPsLTFKEPhosphoSitePlus
S2521PRARKsMSLDMPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S2599RKVSVsESNVLPhosphoSitePlus
S2475TQPWSsPKGSEHPRD
T2510AATYPtVGQTSHPRD
S1567LNLTSsKFEEFPhosphoSitePlus
T2514PTVGQtSPRARPhosphoSitePlus; HPRD; phosphoELM
S926VGLELsPALYPPhosphoSitePlus
S2451SEEVRsRCSLKPhosphoSitePlus
T467MAPSLtFKEKVPhosphoSitePlus
S2829QRSAGsFKRNSPhosphoSitePlus; phosphoELM
T59VISGLtTILKNHPRD
S2781ENVELsPTTGHHPRD
S882MISVMsSEGNAPhosphoSitePlus
S674SAAGCsGTPPIPhosphoSitePlus
S2796RTRHGsASQVQHPRD
S1140RLASLRSysPTM 2.0

Dephosphorylation site
NF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000351015V1757DCOSMICOther Cancer19142971
ENSP00000348498H809YDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000348498G2724RSjoblom2006, BIOMARTBreast Cancer16959974, 21930507, 21930502
ENSP00000348498V1182FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000351015R652CCOSMICHead and Neck Cancer21798893
ENSP00000351015R1306*COSMICNeoplasms by Histologic Type14635100
ENSP00000351015P1951fs*6COSMICOther Cancer17960768
ENSP00000351015R1534*COSMICCentral Nervous System Neoplasms18772890
ENSP00000351015Q1341*COSMICNeoplasms by Histologic Type10677298
ENSP00000351015R461*COSMICNeoplasms by Histologic Type
ENSP00000351015S2549*COSMICCentral Nervous System Neoplasms
ENSP00000351015D176ECOSMICIntestines Cancer12522551
ENSP00000351015A2336TCOSMICCentral Nervous System Neoplasms18772890
ENSP00000351015G849*COSMICCentral Nervous System Neoplasms18772890
ENSP00000348498L210*BIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000351015A1819TCOSMICLung Cancer20668451
ENSP00000351015H712RCOSMICIntestines Cancer12522551
ENSP00000348498L550STCGAOvarian Cancer21720365, 18772890
ENSP00000351015R1412SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000351015Q1447KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000351015R416*COSMICNeoplasms by Histologic Type18484666
ENSP00000351015R816*COSMICLung Cancer20668451
ENSP00000351015F1110fs*2COSMICNeoplasms by Histologic Type16941471
ENSP00000351015W696*COSMICNeoplasms by Histologic Type20358387
ENSP00000351015Q519PCOSMICNeoplasms by Histologic Type14722917
ENSP00000351015R681*COSMICNeoplasms by Histologic Type20358387
ENSP00000348498E163*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000348498G849*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000351015T1598fs*26COSMICNeoplasms by Histologic Type16941471
ENSP00000351015Q1841*COSMICCentral Nervous System Neoplasms18772396
ENSP00000351015Q1987*COSMICCentral Nervous System Neoplasms18772890
ENSP00000348498N2658DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000348498L1187IBIOMARTColorectal Cancer21930507, 21930502
ENSP00000348498S574TDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000351015Q756*COSMICNeoplasms by Histologic Type11115850
ENSP00000351015K1444ECOSMICOvarian Cancer21720365
ENSP00000351015R1276*COSMICLymphoma20067559
ENSP00000351015H553RCOSMICNeoplasms by Histologic Type20655465
ENSP00000351015S2597*COSMICNeoplasms by Histologic Type19738042
ENSP00000348498E1198*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000351015G2745RHPI, COSMICBreast Cancer7981724 8825042 16959974
ENSP00000351015Q2589*COSMICNeoplasms by Histologic Type20358387
ENSP00000351015L21RCOSMICOther Cancer19142971
ENSP00000351015S402LCOSMICBreast Cancer20668451
ENSP00000351015L2158*COSMICLymphoma20505189
ENSP00000351015D633fs*55COSMICCentral Nervous System Neoplasms18772890
ENSP00000351015K2171*COSMICNeoplasms by Histologic Type20358387
ENSP00000351015R1241*COSMICNeoplasms by Histologic Type10677298
ENSP00000351015D1302YCOSMICIntestines Cancer18592002
ENSP00000351015S2484FCOSMICMelanoma
ENSP00000351015N1984TCOSMICNeoplasms by Histologic Type20358387
ENSP00000351015Q554ECOSMICNeoplasms by Histologic Type20358387
ENSP00000348498R997KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000348498Q1820*BIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000351015W1258*COSMICNeoplasms by Histologic Type16941471
ENSP00000351015N2679DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000351015Q684*COSMICNeoplasms by Histologic Type16941471
ENSP00000351015Q535*COSMICLymphoma
ENSP00000351015E1720*COSMICGastric Cancer
ENSP00000348498Q112*TCGAOvarian Cancer21720365, 18772890
ENSP00000351015Q209HCOSMICCentral Nervous System Neoplasms
ENSP00000351015L1590*COSMICNeoplasms by Histologic Type18484666
ENSP00000351015A2032TCOSMICPancreatic Cancer21252315
ENSP00000351015I878TCOSMICLung Cancer20668451
ENSP00000351015E163*COSMICLung Cancer18948947
ENSP00000348498R2237*BIOMARTBrain Cancer21930507, 21930502
ENSP00000351015R1968*COSMICCentral Nervous System Neoplasms18772396
ENSP00000351015P678fs*10COSMICIntestines Cancer12522551
ENSP00000351015V1182FCOSMICLung Cancer18948947
ENSP00000348498P1930LSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000351015I1223VCOSMICLung Cancer20668451
ENSP00000351015L1587*COSMICNeoplasms by Histologic Type16941471
ENSP00000351015P1548LCOSMICLung Cancer20668451
ENSP00000351015M799fs*22COSMICLung Cancer
ENSP00000351015L1187IHPIColorectal Cancer7981724 8825042 16959974
ENSP00000351015F250fs*31COSMICNeoplasms by Histologic Type17551851
ENSP00000351015Q1336*COSMICMelanoma
ENSP00000351015L2416VCOSMICOvarian Cancer21720365
ENSP00000351015R1830CCOSMICCentral Nervous System Neoplasms18772396
ENSP00000351015R997KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000351015T2004fs*8COSMICCentral Nervous System Neoplasms18772890
ENSP00000351015R1362*COSMICNeoplasms by Histologic Type20358387
ENSP00000348498P1930LBIOMARTColorectal Cancer21930507, 21930502
ENSP00000351015E91KCOSMICNeoplasms by Histologic Type18484666
ENSP00000351015L1946fs*4COSMICNeoplasms by Histologic Type11409870
ENSP00000348498L194PTCGAOvarian Cancer21720365, 18772890
ENSP00000351015R304*COSMICCentral Nervous System Neoplasms18772890
ENSP00000351015P1951LCOSMICIntestines Cancer16959974
ENSP00000348498S1140*BIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000351015Q369*COSMICNeoplasms by Histologic Type16941471
ENSP00000351015N939fs*15COSMICNeoplasms by Histologic Type11409870
ENSP00000351015L532fs*24COSMICOther Cancer17960768
ENSP00000351015D2375HBIOMARTBreast Cancer21930507, 21930502
ENSP00000351015L194PCOSMICOvarian Cancer21720365
ENSP00000351015N1603fs*21COSMICNeoplasms by Histologic Type17551851
ENSP00000351015S1150LCOSMICNeoplasms by Histologic Type20358387
ENSP00000351015S1100ACOSMICOvarian Cancer20668451
ENSP00000351015S2181GCOSMICNeoplasms by Histologic Type20358387
ENSP00000351015G949fs*5COSMICNeoplasms by Histologic Type17551851
ENSP00000351015E2501fs*22COSMICNeoplasms by Histologic Type16941471
ENSP00000348498R192*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000351015S2810GCOSMICLung Cancer20668451
ENSP00000348498Q209HBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000351015H712RHPIOther Cancer7981724 8825042 12522551
ENSP00000351015R135fs*30COSMICNeoplasms by Histologic Type19738042
ENSP00000351015Q1017*COSMICNeoplasms by Histologic Type14635100
ENSP00000351015R192*COSMICCentral Nervous System Neoplasms18772890
ENSP00000351015R2150SCOSMICNeoplasms by Histologic Type14722917
ENSP00000351015W2317*COSMICCentral Nervous System Neoplasms18772890
ENSP00000351015R1204WCOSMICOvarian Cancer20668451
ENSP00000351015D2635fs*9COSMICCentral Nervous System Neoplasms
ENSP00000351015K1771*COSMICNeoplasms by Histologic Type22034633
ENSP00000351015W696fs*1COSMICNeoplasms by Histologic Type14722917
ENSP00000351015R440*COSMICNeoplasms by Histologic Type22034633
ENSP00000351015E1919KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000351015C167*COSMICThyroid Carcinoma
ENSP00000351015L180*COSMICOther Cancer19142971
ENSP00000351015S749*COSMICNeoplasms by Histologic Type11409870
ENSP00000351015G1649RCOSMICHead and Neck Cancer21798893
ENSP00000348498E517*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000351015V2391FCOSMICLung Cancer20668451
ENSP00000351015C1063*COSMICNeoplasms by Histologic Type16941471
ENSP00000348498R304*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000351015G922VCOSMICLung Cancer18948947
ENSP00000348498D2354HBIOMARTBreast Cancer21930507, 21930502
ENSP00000351015L274RCOSMICLymphoma20015894
ENSP00000351015C1882FCOSMICLung Cancer18948947
ENSP00000351015P1951LHPIColorectal Cancer7981724 8825042 16959974
ENSP00000351015Q2588*COSMICNeoplasms by Histologic Type20358387
ENSP00000351015I941fs*13COSMICCentral Nervous System Neoplasms
ENSP00000351015Y2285*COSMICOther Cancer19142971
ENSP00000348498K1423NBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000351015H809YCOSMICLung Cancer18948947
ENSP00000351015R1136WCOSMICLung Cancer20668451
ENSP00000351015R1276QCOSMICIntestines Cancer12522551
ENSP00000351015S1140*COSMICCentral Nervous System Neoplasms
ENSP00000348498L1187ISjoblom2006Intestines Cancer16959974, 7981724, 8825042, 21930507, 21930502
ENSP00000348498G922VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000351015L2338fs*8COSMICCentral Nervous System Neoplasms18772890
ENSP00000351015E2214*COSMICOvarian Cancer21720365
ENSP00000351015D2632E + p.E2633*Ding2008Lung Cancer18948947
ENSP00000348498S2311*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000351015A74DHPIOther Cancer7981724 8825042 12522551
ENSP00000351015D176EHPIOther Cancer7981724 8825042 10712197 12522551 15146469 15060124 10726756
ENSP00000348498C1861FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000348498R1809CBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000351015I23LCOSMICNeoplasms by Histologic Type20358387
ENSP00000348498S2528*BIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000351015S1759FCOSMICSkin Cancer21984974
ENSP00000351015W1662*COSMICCentral Nervous System Neoplasms18772890
ENSP00000351015P2477SCOSMICIntestines Cancer12522551
ENSP00000351015S2332*COSMICCentral Nervous System Neoplasms18772890
ENSP00000348498Q835HDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000351015S1786*COSMICOvarian Cancer21720365
ENSP00000348498I526SBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000351015D1849NCOSMICCentral Nervous System Neoplasms18772890
ENSP00000351015E517*COSMICLung Cancer18948947
ENSP00000351015L210*COSMICCentral Nervous System Neoplasms
ENSP00000351015L161*COSMICLymphoma20015894
ENSP00000351015Y1106CCOSMICHepatocellular Carcinoma21822264
ENSP00000351015R1769*COSMICCentral Nervous System Neoplasms18772890
ENSP00000351015M1539ICOSMICSkin Cancer21984974
ENSP00000351015Q112*COSMICOvarian Cancer21720365
ENSP00000351015L1187ISjoblom2006, COSMICIntestines Cancer16959974, 7981724, 8825042, 7981724, 8825042, 16959974
ENSP00000351015E1198*COSMICLung Cancer18948947
ENSP00000351015N2341fs*5COSMICIntestines Cancer
ENSP00000351015Q835HCOSMICLung Cancer18948947
ENSP00000348498F1392VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000351015K1099ICOSMICCentral Nervous System Neoplasms
ENSP00000351015L550PCOSMICOvarian Cancer21720365
ENSP00000348498K1099IBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000351015R385fs*2COSMICNeoplasms by Histologic Type16941471
ENSP00000351015E1688*COSMICHead and Neck Cancer21798893
ENSP00000351015A1858TCOSMICOvarian Cancer21720365
ENSP00000348498G1842ATCGAOvarian Cancer21720365, 18772890
ENSP00000351015Q2302fs*17COSMICCentral Nervous System Neoplasms18772890
ENSP00000351015Y1607fs*17COSMICIntestines Cancer12522551
ENSP00000351015D2095fs*16COSMICOther Cancer19142971
ENSP00000351015P2472HCOSMICProstate Cancer12522551
ENSP00000351015G1863ACOSMICOvarian Cancer21720365
ENSP00000351015R2450*COSMICNeoplasms by Histologic Type14722917
ENSP00000351015F2156LCOSMICRenal Cancer20054297
ENSP00000351015Y628fs*3COSMICIntestines Cancer
ENSP00000351015V630fs*1COSMICNeoplasms by Histologic Type14722917
ENSP00000351015I526SCOSMICCentral Nervous System Neoplasms
ENSP00000351015E196*COSMICNeoplasms by Histologic Type20358387
ENSP00000351015Q1815*COSMICNeoplasms by Histologic Type20358387
ENSP00000351015K583RCOSMICLymphoma20015894
ENSP00000351015A74DCOSMICIntestines Cancer12522551
ENSP00000348498R1947*BIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000351015S574TCOSMICLung Cancer18948947

Differential expressed protein
NF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NF1_HUMANRRAS2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0014044Schwann cell developmentISSbiological_process
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0030336negative regulation of cell migrationIMPbiological_process
GO:0045765regulation of angiogenesisIMPbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0005488bindingIEAmolecular_function
GO:0048485sympathetic nervous system developmentIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0007154cell communicationISSbiological_process
GO:0021915neural tube developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0032320positive regulation of Ras GTPase activityISSbiological_process
GO:0008542visual learningIEAbiological_process
GO:0046580negative regulation of Ras protein signal transducIBAbiological_process
GO:0048485sympathetic nervous system developmentISSbiological_process
GO:0022011myelination in peripheral nervous systemISSbiological_process
GO:0035021negative regulation of Rac protein signal transducIEAbiological_process
GO:0001952regulation of cell-matrix adhesionISSbiological_process
GO:0030325adrenal gland developmentISSbiological_process
GO:0001666response to hypoxiaISSbiological_process
GO:0022011myelination in peripheral nervous systemIEAbiological_process
GO:0030424axonIDAcellular_component
GO:0006469negative regulation of protein kinase activityIEAbiological_process
GO:0007422peripheral nervous system developmentIEAbiological_process
GO:0043065positive regulation of apoptotic processISSbiological_process
GO:0042992negative regulation of transcription factor importIEAbiological_process
GO:0006469negative regulation of protein kinase activityISSbiological_process
GO:0021897forebrain astrocyte developmentIEAbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0021510spinal cord developmentIEAbiological_process
GO:0007519skeletal muscle tissue developmentIEAbiological_process
GO:0045685regulation of glial cell differentiationISSbiological_process
GO:0043409negative regulation of MAPK cascadeISSbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0048853forebrain morphogenesisIEAbiological_process
GO:0043525positive regulation of neuron apoptotic processISSbiological_process
GO:0030036actin cytoskeleton organizationISSbiological_process
GO:0005622intracellularIEAcellular_component
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0045124regulation of bone resorptionIEAbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeIEAbiological_process
GO:0043473pigmentationISSbiological_process
GO:0007406negative regulation of neuroblast proliferationISSbiological_process
GO:0014044Schwann cell developmentIEAbiological_process
GO:0030425dendriteIDAcellular_component
GO:0021987cerebral cortex developmentIEAbiological_process
GO:0030198extracellular matrix organizationISSbiological_process
GO:0042060wound healingIEAbiological_process
GO:0043407negative regulation of MAP kinase activityISSbiological_process
GO:0007422peripheral nervous system developmentISSbiological_process
GO:0048853forebrain morphogenesisISSbiological_process
GO:0030325adrenal gland developmentIEAbiological_process
GO:0043535regulation of blood vessel endothelial cell migratIMPbiological_process
GO:0001889liver developmentISSbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeISSbiological_process
GO:0007265Ras protein signal transductionISSbiological_process
GO:0043409negative regulation of MAPK cascadeIEAbiological_process
GO:0032228regulation of synaptic transmission, GABAergicIEAbiological_process
GO:0001953negative regulation of cell-matrix adhesionIEAbiological_process
GO:0005634nucleusISScellular_component
GO:0001656metanephros developmentISSbiological_process
GO:0046929negative regulation of neurotransmitter secretionIEAbiological_process
GO:0050890cognitionIMPbiological_process
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0008542visual learningISSbiological_process
GO:0001656metanephros developmentIEAbiological_process
GO:0048715negative regulation of oligodendrocyte differentiaISSbiological_process
GO:0001937negative regulation of endothelial cell proliferatIMPbiological_process
GO:0021510spinal cord developmentISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030199collagen fibril organizationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007154cell communicationIEAbiological_process
GO:0048715negative regulation of oligodendrocyte differentiaIEAbiological_process
GO:0048745smooth muscle tissue developmentISSbiological_process
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0045762positive regulation of adenylate cyclase activityIEAbiological_process
GO:0046580negative regulation of Ras protein signal transducIEAbiological_process
GO:0048593camera-type eye morphogenesisISSbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0000165MAPK cascadeISSbiological_process
GO:0032318regulation of Ras GTPase activityIMPbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0016525negative regulation of angiogenesisIEAbiological_process
GO:0001952regulation of cell-matrix adhesionIEAbiological_process
GO:0043473pigmentationIEAbiological_process
GO:0045671negative regulation of osteoclast differentiationIEAbiological_process
GO:0001649osteoblast differentiationISSbiological_process
GO:0007420brain developmentISSbiological_process
GO:0048844artery morphogenesisISSbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0005737cytoplasmIBAcellular_component
GO:0005099Ras GTPase activator activityIDAmolecular_function
GO:0048844artery morphogenesisIEAbiological_process
GO:0048712negative regulation of astrocyte differentiationIEAbiological_process
GO:0048745smooth muscle tissue developmentIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0045762positive regulation of adenylate cyclase activityISSbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0048593camera-type eye morphogenesisIEAbiological_process
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0005096GTPase activator activityIEAmolecular_function
GO:0048147negative regulation of fibroblast proliferationIEAbiological_process
GO:0045124regulation of bone resorptionISSbiological_process
GO:0007265Ras protein signal transductionIEAbiological_process
GO:0030199collagen fibril organizationISSbiological_process
GO:0032320positive regulation of Ras GTPase activityIEAbiological_process
GO:0007406negative regulation of neuroblast proliferationIEAbiological_process
GO:0021897forebrain astrocyte developmentISSbiological_process
GO:0042992negative regulation of transcription factor importISSbiological_process
GO:0031235intrinsic to internal side of plasma membraneIBAcellular_component
GO:0007507heart developmentISSbiological_process
GO:0045765regulation of angiogenesisIEAbiological_process
GO:0001937negative regulation of endothelial cell proliferatIEAbiological_process
GO:0045685regulation of glial cell differentiationIEAbiological_process
GO:0021987cerebral cortex developmentISSbiological_process
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0042060wound healingISSbiological_process


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