Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTN11_HUMAN
Description:protein tyrosine phosphatase, non-receptor type 11 [Source:HGNC Symbol;Acc:9644]
Location:chr12 q24.13
Node attribute:substrate; kinase; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y551YTNIKySLADQDUF1092PhosphoSitePlus
Y63NTGDYyDLYGGSH2PhosphoSitePlus
Y304EPVSDyINANIY_phosphatasePhosphoSitePlus
Y584DSARVyENVGLPDGFR_groupRegPhos
T570PPCTPtPPCAEPhosphoSitePlus
Y546RKGHEyTNIKYPDGFRbRegPhos
T59IKIQNtGDYYDSH2PhosphoSitePlus
S576EMREDsARVYEPRKCAHPRD
S576EMREDsARVYEPRKCBHPRD
S595MQQQKsFRRegPhos
S562TSGDQsPLPPCDUF1092PhosphoSitePlus
Y62QNTGDyYDLYGHPRD; phosphoELM; RegPhos
T557SLADQtSGDQSDUF1092PhosphoSitePlus
Y80AELVQyYMEHHSH2PhosphoSitePlus
S595MQQQKsphosphoELM
Y519QYRFIyMAVQHY_phosphatase; DUF1092PhosphoSitePlus
Y179CQELKyDVGGGSH2PhosphoSitePlus
Y546RKGHEyTNIKYPDGFR_groupRegPhos
Y546RKGHEyTNIKYPDGFR_betaphosphoELM
S595MQQQKsFR___PhosphoSitePlus
S264CKLLYsRKEGQPhosphoSitePlus
T568PLPPCtPTPPCDUF1092PhosphoSitePlus
S580EMREDsARVYEPKChRegPhos
S580EMREDsARVYEPKCbRegPhos
S580EMREDsARVYEPKCaRegPhos
Y62QNTGDyYDLYGSH2PhosphoSitePlus
S34FLARPsKSNPGSH2PhosphoSitePlus
Y546RKGHEyTNIKYphosphoELM
Y304EPVSDyINANIphosphoELM; RegPhos
S552TNIKYsLADQTDUF1092PhosphoSitePlus
Y279KNKNRyKNILPY_phosphatasePhosphoSitePlus
S302PNEPVsDYINAY_phosphatasePhosphoSitePlus
S558TSGDQsPLPPCHPRD
T415LLQGNtERTVWY_phosphatasePhosphoSitePlus
Y263ECKLLySRKEGPhosphoSitePlus
Y515QTEAQyRFIYMY_phosphatase; DUF1092PhosphoSitePlus
Y66DYYDLyGGEKFSH2PhosphoSitePlus
Y580DSARVyENVGLHPRD
Y66DYYDLyGGEKFHPRD; RegPhos
S576EMREDsARVYEPRKCHHPRD
S591MQQQKsHPRD
S580EMREDsARVYEPhosphoSitePlus
Y63NTGDYyDLYGGHPRD; phosphoELM
Y584DSARVyENVGLPhosphoSitePlus; phosphoELM; RegPhos
Y542RKGHEyTNIKYPDGFRBHPRD
T153VLSVRtGDDKGSH2PhosphoSitePlus
Y546RKGHEyTNIKYDUF1092PhosphoSitePlus
S28RGVDGsFLARPSH2PhosphoSitePlus
Y279KNKNRyKNILPHPRD
S165SNDGKsKVTHVSH2PhosphoSitePlus
T547KGHEYtNIKYSDUF1092PhosphoSitePlus

Dephosphorylation site
PTN11_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000340944L74MCOSMICLymphoma17972951
ENSP00000340944T52SCOSMICLymphoma15928039
ENSP00000340944N58SCOSMICLung Cancer15604238
ENSP00000340944R152HCOSMICLymphoma16518851
ENSP00000340944D61VCOSMICLymphoma16518851
ENSP00000340944R289GCOSMICLymphoma15604238
ENSP00000340944P491LCOSMICLymphoma14982869
ENSP00000340944S502LDing2008Neoplasms by Histologic Type15385933, 17910045, 18428421, 18948947
ENSP00000340944I282MTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000340944A72VCOSMICLymphoma15749679
ENSP00000340944S502TCOSMICLymphoma16358218
ENSP00000340944E69KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000340944N339STCGAOvarian Cancer21720365, 18772890
ENSP00000340944E139DCOSMICLymphoma14644997
ENSP00000340944G60RCOSMICLymphoma15951301
ENSP00000340944T73ICOSMICLymphoma16358218
ENSP00000340944G503VDing2008Neoplasms by Histologic Type15834506, 15928039, 18428421, 18948947
ENSP00000340944Q510KCOSMICLymphoma14982869
ENSP00000340944T507KCOSMICNeoplasms by Histologic Type15604238
ENSP00000340944V45LCOSMICLung Cancer15604238
ENSP00000340944N308DCOSMICLymphoma16533526
ENSP00000340944Y418*Ding2008, COSMICLung Cancer18948947
ENSP00000340944Y63CCOSMICLymphoma14644997
ENSP00000340944I282MCOSMICCentral Nervous System Neoplasms18772890
ENSP00000340944G503ACOSMICLymphoma15951301
ENSP00000340944F71KCOSMICLymphoma16115145
ENSP00000340944E76GCOSMICLymphoma16518851
ENSP00000340944G503VDing2008, BIOMARTLung Cancer15834506, 15928039, 18428421, 18948947, 21930507, 21930502
ENSP00000340944N339SCOSMICOvarian Cancer21720365
ENSP00000340944S502LDing2008, BIOMARTLung Cancer15385933, 17910045, 18428421, 18948947, 21930507, 21930502
ENSP00000340944L77VCOSMICLymphoma16358218
ENSP00000340944H53QCOSMICLymphoma15749679
ENSP00000340944R138QCOSMICMelanoma15604238
ENSP00000340944S189ABIOMARTGastric Cancer21930507, 21930502

Differential expressed protein
PTN11_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y584REDSARVyENVGLMQlymphoma17483340PhosphoSitePlus
Y546DUF1092SKRKGHEyTNIKYSLlymphoma17483340PhosphoSitePlus
Y62SH2KIQNTGDyYDLYGGEcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANPTN11_HUMANkinase -> substrateHPRD
KPCB_HUMANPTN11_HUMANkinase -> substrateHPRD
PTN11_HUMANFAK2_HUMANkinase -> substrateHPRD
JAK2_HUMANPTN11_HUMANkinase -> substrateKEGG
ZAGL2_HUMANPTN11_HUMANkinase -> substrateRegPhos
KPCL_HUMANPTN11_HUMANkinase -> substrateHPRD
JAK1_HUMANPTN11_HUMANkinase -> substrateKEGG
PGFRB_HUMANPTN11_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PTN11_HUMANSTA5A_HUMANphosphatase -> substrateHPRD; NetPath
PTN11_HUMANJAK2_HUMANphosphatase -> substrateHPRD
PTN11_HUMANSTA5B_HUMANphosphatase -> substrateHPRD; NetPath
PTN11_HUMANSTAT1_HUMANphosphatase -> substrateHPRD
PTN11_HUMANVGFR1_HUMANphosphatase -> substrateHPRD
PTN11_HUMANEGFR_HUMANphosphatase -> substrateHPRD
PTN11_HUMANSHPS1_HUMANphosphatase -> substrateHPRD
PTN11_HUMANFRS2_HUMANphosphatase -> substrateHPRD
PTN11_HUMANPECA1_HUMANphosphatase -> substrateHPRD
PTN11_HUMANLYAM2_HUMANphosphatase -> substrateHPRD
PTN11_HUMANGAB1_HUMANphosphatase -> substrateHPRD
PTN11_HUMANPGFRB_HUMANphosphatase -> substrateHPRD
PTN11_HUMANGAB2_HUMANphosphatase -> substrateHPRD
PTN11_HUMANIRS1_HUMANphosphatase -> substrateHPRD
PTN11_HUMANIL6RB_HUMANphosphatase -> substrateHPRD
PTN11_HUMANMPZL1_HUMANphosphatase -> substrateHPRD
PTN11_HUMANTIE2_HUMANphosphatase -> substrateHPRD
PTN11_HUMANIL3RB_HUMANphosphatase -> substrateHPRD
PTN11_HUMANFAK2_HUMANphosphatase -> substrateHPRD; NetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05168Herpes simplex infection
hsa04650Natural killer cell mediated cytotoxicity
hsa04670Leukocyte transendothelial migration
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04920Adipocytokine signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05220Chronic myeloid leukemia
hsa05211Renal cell carcinoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060338regulation of type I interferon-mediated signalingTASbiological_process
GO:0046887positive regulation of hormone secretionIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0048609multicellular organismal reproductive processIEAbiological_process
GO:0033628regulation of cell adhesion mediated by integrinIMPbiological_process
GO:0043560insulin receptor substrate bindingIEAmolecular_function
GO:0004721phosphoprotein phosphatase activityIEAmolecular_function
GO:0046676negative regulation of insulin secretionIEAbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0035335peptidyl-tyrosine dephosphorylationIMPbiological_process
GO:0060125negative regulation of growth hormone secretionIEAbiological_process
GO:0048013ephrin receptor signaling pathwayIDAbiological_process
GO:0060334regulation of interferon-gamma-mediated signaling TASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0050900leukocyte migrationTASbiological_process
GO:0004725protein tyrosine phosphatase activityTASmolecular_function
GO:0009755hormone-mediated signaling pathwayIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayIEAbiological_process
GO:0005070SH3/SH2 adaptor activityIDAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0000077DNA damage checkpointIEAbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0046825regulation of protein export from nucleusIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043274phospholipase bindingIEAmolecular_function
GO:0016791phosphatase activityIEAmolecular_function
GO:0035265organ growthIEAbiological_process
GO:0005158insulin receptor bindingIPImolecular_function
GO:0042593glucose homeostasisIEAbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0051428peptide hormone receptor bindingIEAmolecular_function
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0006641triglyceride metabolic processIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0005158insulin receptor bindingIEAmolecular_function
GO:2001275positive regulation of glucose import in response IDAbiological_process
GO:0051463negative regulation of cortisol secretionIEAbiological_process
GO:0009967positive regulation of signal transductionIEAbiological_process
GO:0042445hormone metabolic processIEAbiological_process
GO:0000187activation of MAPK activityIEAbiological_process
GO:0016311dephosphorylationIEAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0046888negative regulation of hormone secretionIEAbiological_process
GO:0004726non-membrane spanning protein tyrosine phosphataseIMPmolecular_function
GO:0040014regulation of multicellular organism growthIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005829cytosolTAScellular_component
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0030971receptor tyrosine kinase bindingIEAmolecular_function