| UniProt/SwissProt ID: | FRS2_HUMAN |
| Description: | fibroblast growth factor receptor substrate 2 [Source:HGNC Symbol;Acc:16971] |
| Location: | chr12 q15 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S221 | LEARVsNAESS | PhosphoSitePlus; HPRD | |
| T463 | TPLPQtPTRRT | PhosphoSitePlus | |
| T326 | RRGRLtSTSTS | PhosphoSitePlus | |
| T468 | TPTRRtELYAV | PhosphoSitePlus; HPRD | |
| S169 | SSRHPsVGSAR | PhosphoSitePlus | |
| T504 | TRHNStDLPM_ | PhosphoSitePlus | |
| T132 | LEVPRtPRTPT | PhosphoSitePlus | |
| S226 | SNAESsTPKEE | PhosphoSitePlus | |
| Y392 | DPMHNyVNTEN | PhosphoSitePlus | |
| Y349 | TALLNyENLPS | PhosphoSitePlus | |
| T135 | PRTPRtPTTPG | PhosphoSitePlus | |
| T465 | LPQTPtRRTEL | PhosphoSitePlus | |
| T458 | PKTPTtPLPQT | PhosphoSitePlus | |
| T137 | TPRTPtTPGFA | PhosphoSitePlus | |
| T395 | HNYVNtENVTV | PhosphoSitePlus | |
| S327 | RGRLTsTSTSD | PhosphoSitePlus | |
| T328 | GRLTStSTSDT | PhosphoSitePlus | |
| Y196 | EQVHTyVNTTG | PhosphoSitePlus | |
| S503 | KTRHNsTDLPM | PhosphoSitePlus | |
| T455 | PQTPKtPTTPL | PhosphoSitePlus | |
| S316 | GLSIPsASGVR | HPRD | |
| S155 | YPRYPsFGDAS | PhosphoSitePlus | |
| Y306 | VNKLVyENING | PhosphoSitePlus | |
| Y290 | EWDTGyDSDER | PhosphoSitePlus | |
| T49 | ELILYtRKRDS | IRS | PhosphoSitePlus |
| Y59 | SVKWHyLCLRR | IRS | PhosphoSitePlus |
| S483 | RTAAMsNLQKA | HPRD | |
| T344 | SAQRRtALLNY | PhosphoSitePlus | |
| T479 | IDIERtAAMSN | HPRD | |
| S73 | DSNLFsFESGR | IRS | PhosphoSitePlus |
| Y150 | NLPNGyPRYPS | PhosphoSitePlus | |
| S177 | SARLPsVGEES | PhosphoSitePlus | |
| Y471 | RRTELyAVIDI | PhosphoSitePlus | |
| T138 | PRTPTtPGFAA | PhosphoSitePlus | |
| S76 | LFSFEsGRRCQ | IRS | PhosphoSitePlus |
| S354 | YENLPsLPPVW | PhosphoSitePlus | |
| S403 | VTVPAsAHKIE | PhosphoSitePlus | |
| T227 | NAESStPKEEP | PhosphoSitePlus; HPRD | |
| T125 | RNNHQtELEVP | PhosphoSitePlus | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y436 | LEHRQLNyIQVDLEG | PTPN11 | HPRD |
| Mutation site |
| FRS2_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000381083 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| FRS2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PTN11_HUMAN | FRS2_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04722 | Neurotrophin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0046619 | optic placode formation involved in camera-type ey | IEA | biological_process |
| GO:0008595 | anterior/posterior axis specification, embryo | IEA | biological_process |
| GO:0005104 | fibroblast growth factor receptor binding | IPI | molecular_function |
| GO:0007405 | neuroblast proliferation | IEA | biological_process |
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005068 | transmembrane receptor protein tyrosine kinase ada | IEA | molecular_function |
| GO:0005158 | insulin receptor binding | IEA | molecular_function |
| GO:0012505 | endomembrane system | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005168 | neurotrophin TRKA receptor binding | IPI | molecular_function |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | IEA | biological_process |
| GO:0005768 | endosome | TAS | cellular_component |
| GO:0000186 | activation of MAPKK activity | TAS | biological_process |
| GO:0001759 | organ induction | IEA | biological_process |
| GO:0001702 | gastrulation with mouth forming second | IEA | biological_process |
| GO:0019211 | phosphatase activator activity | TAS | molecular_function |
| GO:0050678 | regulation of epithelial cell proliferation | IEA | biological_process |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0000187 | activation of MAPK activity | IEA | biological_process |
| GO:0030900 | forebrain development | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0060527 | prostate epithelial cord arborization involved in | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatas | TAS | biological_process |
| GO:0003281 | ventricular septum development | IEA | biological_process |