Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FRS2_HUMAN
Description:fibroblast growth factor receptor substrate 2 [Source:HGNC Symbol;Acc:16971]
Location:chr12 q15
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S221LEARVsNAESSPhosphoSitePlus; HPRD
T463TPLPQtPTRRTPhosphoSitePlus
T326RRGRLtSTSTSPhosphoSitePlus
T468TPTRRtELYAVPhosphoSitePlus; HPRD
S169SSRHPsVGSARPhosphoSitePlus
T504TRHNStDLPM_PhosphoSitePlus
T132LEVPRtPRTPTPhosphoSitePlus
S226SNAESsTPKEEPhosphoSitePlus
Y392DPMHNyVNTENPhosphoSitePlus
Y349TALLNyENLPSPhosphoSitePlus
T135PRTPRtPTTPGPhosphoSitePlus
T465LPQTPtRRTELPhosphoSitePlus
T458PKTPTtPLPQTPhosphoSitePlus
T137TPRTPtTPGFAPhosphoSitePlus
T395HNYVNtENVTVPhosphoSitePlus
S327RGRLTsTSTSDPhosphoSitePlus
T328GRLTStSTSDTPhosphoSitePlus
Y196EQVHTyVNTTGPhosphoSitePlus
S503KTRHNsTDLPMPhosphoSitePlus
T455PQTPKtPTTPLPhosphoSitePlus
S316GLSIPsASGVRHPRD
S155YPRYPsFGDASPhosphoSitePlus
Y306VNKLVyENINGPhosphoSitePlus
Y290EWDTGyDSDERPhosphoSitePlus
T49ELILYtRKRDSIRSPhosphoSitePlus
Y59SVKWHyLCLRRIRSPhosphoSitePlus
S483RTAAMsNLQKAHPRD
T344SAQRRtALLNYPhosphoSitePlus
T479IDIERtAAMSNHPRD
S73DSNLFsFESGRIRSPhosphoSitePlus
Y150NLPNGyPRYPSPhosphoSitePlus
S177SARLPsVGEESPhosphoSitePlus
Y471RRTELyAVIDIPhosphoSitePlus
T138PRTPTtPGFAAPhosphoSitePlus
S76LFSFEsGRRCQIRSPhosphoSitePlus
S354YENLPsLPPVWPhosphoSitePlus
S403VTVPAsAHKIEPhosphoSitePlus
T227NAESStPKEEPPhosphoSitePlus; HPRD
T125RNNHQtELEVPPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y436LEHRQLNyIQVDLEGPTPN11HPRD

Mutation site
FRS2_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000381083Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
FRS2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PTN11_HUMANFRS2_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneTAScellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0046619optic placode formation involved in camera-type eyIEAbiological_process
GO:0008595anterior/posterior axis specification, embryoIEAbiological_process
GO:0005104fibroblast growth factor receptor bindingIPImolecular_function
GO:0007405neuroblast proliferationIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0005068transmembrane receptor protein tyrosine kinase adaIEAmolecular_function
GO:0005158insulin receptor bindingIEAmolecular_function
GO:0012505endomembrane systemIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005168neurotrophin TRKA receptor bindingIPImolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaIEAbiological_process
GO:0005768endosomeTAScellular_component
GO:0000186activation of MAPKK activityTASbiological_process
GO:0001759organ inductionIEAbiological_process
GO:0001702gastrulation with mouth forming secondIEAbiological_process
GO:0019211phosphatase activator activityTASmolecular_function
GO:0050678regulation of epithelial cell proliferationIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0000187activation of MAPK activityIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0060527prostate epithelial cord arborization involved in IEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007185transmembrane receptor protein tyrosine phosphatasTASbiological_process
GO:0003281ventricular septum developmentIEAbiological_process


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