Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLCB1_HUMAN
Description:phospholipase C, beta 1 (phosphoinositide-specific) [Source:HGNC Symbol;Acc:15917]
Location:chr20 p12.3
Node attribute:PPI(source); substrate; effector; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T336HNTYLtAGQLARegPhos
S136TNEVFsLATNLPhosphoSitePlus
Y334SSHNTyLTAGQRegPhos
T139VFSLAtNLLAQPhosphoSitePlus
S981KKSEPsSPDHGPhosphoSitePlus
S887QPAPGsVKAPAPKC_group RegPhos
S982KSEPSsPDHGSErk1(MAPK3RegPhos
S887QPAPGsVKAPAPKCdRegPhos
S887QPAPGsVKAPAPKCaRegPhos
S887QPAPGsVKAPAPRKCDHPRD
S887QPAPGsVKAPAPRKCAHPRD
S524DCKKSsMDEGTPhosphoSitePlus
S982KSEPSsPDHGSMAPK3HPRD; phosphoELM
S978DSKKKsEPSSPPhosphoSitePlus
T802DYVPDtYADVIPhosphoSitePlus
Y816SNPIRyVNLMEPhosphoSitePlus
Y444EPLEKyPLESGPI-PLC-XPhosphoSitePlus
S448KYPLEsGVPLPPI-PLC-XPhosphoSitePlus
Y107MITVVyGPDLVPhosphoSitePlus
T26SLKKGtKFVKWPhosphoSitePlus
S988PDHGSsTIEQDPhosphoSitePlus
T573SSFVEtKGLEQHPRD; RegPhos
S887QPAPGsVKAPAPhosphoSitePlus
Y1102EMIRSyIQEVVPLC-beta_CPhosphoSitePlus
S987SPDHGsSTIEQPhosphoSitePlus
S918LKQQKsFVKLQPhosphoSitePlus; HPRD
T333NSSHNtYLTAGRegPhos
S569SFEMSsFVETKHPRD; RegPhos
S500SMFEPsSPGAGPhosphoSitePlus
Y1109QEVVQyIKRLEPLC-beta_CPhosphoSitePlus
S558ESFEIsKKRNKPI-PLC-YPhosphoSitePlus
S982KSEPSsPDHGSPhosphoSitePlus; RegPhos
S887QPAPGsVKAPAPKC_groupphosphoELM; RegPhos
S501MFEPSsPGAGEPhosphoSitePlus
S982KSEPSsPDHGSErk1RegPhos

Dephosphorylation site
PLCB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000338185G703ATCGAOvarian Cancer21720365, 18772890
ENSP00000338185E833KCOSMICHead and Neck Cancer21798893
ENSP00000338185Y107HBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000338185E808KCOSMICSkin Cancer21984974
ENSP00000338185E224KBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000338185L688FCOSMICMelanoma21499247
ENSP00000338185A907PSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000338185P109RCOSMICHepatocellular Carcinoma21822264
ENSP00000338185P406SCOSMICSkin Cancer21984974
ENSP00000338185F713VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000338185Q1013HCOSMICLung Cancer
ENSP00000338185Y460CTCGAOvarian Cancer21720365, 18772890
ENSP00000338185P238SBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000338185Q1050KCOSMICOvarian Cancer21720365
ENSP00000338185A809VCOSMICSkin Cancer21984974
ENSP00000338185S319YCOSMICHead and Neck Cancer21798897
ENSP00000338185E539KCOSMICOvarian Cancer21720365
ENSP00000338185G703ACOSMICOvarian Cancer21720365
ENSP00000338185Q421*COSMICHead and Neck Cancer21798897
ENSP00000338185Y460CCOSMICOvarian Cancer21720365
ENSP00000338185E539KTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
PLCB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PLCB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNA11_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBG5_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBG3_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBG1_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBG10_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBG12_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBB5_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GNA15_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBG8_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBG13_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBB2_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBB1_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBG2_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GNAQ_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBG11_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBB3_HUMANPLCB1_HUMANGprotein -> effectorgpDB
KPCA_HUMANPLCB1_HUMANkinase -> substrateHPRD
KPCD_HUMANPLCB1_HUMANkinase -> substrateHPRD
MK03_HUMANPLCB1_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
ZAGL2_HUMANPLCB1_HUMANkinase -> substrateRegPhos
MK01_HUMANPLCB1_HUMANkinase -> substrateNetPath
GNA11_HUMANPLCB1_HUMANotherKEGG
FZD10_HUMANPLCB1_HUMANotherKEGG
PLCB1_HUMANCHP1_HUMANotherKEGG
PLCB1_HUMANKPCA_HUMANotherKEGG
PLCB1_HUMANITPR1_HUMANotherKEGG
GNAQ_HUMANPLCB1_HUMANotherKEGG
PLCB1_HUMANKCC2A_HUMANotherKEGG
SFRP1_HUMANPLCB1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04971Gastric acid secretion
hsa01100Metabolic pathways
hsa04062Chemokine signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa05143African trypanosomiasis
hsa04720Long-term potentiation
hsa04724Glutamatergic synapse
hsa04730Long-term depression
hsa04961Endocrine and other factor-regulated calcium reabs
hsa04970Salivary secretion
hsa04912GnRH signaling pathway
hsa05146Amoebiasis
hsa04916Melanogenesis
hsa04972Pancreatic secretion
hsa04540Gap junction
hsa04728Dopaminergic synapse
hsa04310Wnt signaling pathway
hsa05016Huntington's disease
hsa04725Cholinergic synapse
hsa00562Inositol phosphate metabolism
hsa05142Chagas disease (American trypanosomiasis)
hsa04726Serotonergic synapse
hsa04270Vascular smooth muscle contraction
hsa04020Calcium signaling pathway
hsa05010Alzheimer's disease
hsa04070Phosphatidylinositol signaling system

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005096GTPase activator activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0051318G1 phaseISSbiological_process
GO:0007215glutamate receptor signaling pathwayIEAbiological_process
GO:0031965nuclear membraneIEAcellular_component
GO:0016607nuclear speckIDAcellular_component
GO:0007213G-protein coupled acetylcholine receptor signalingIEAbiological_process
GO:0007213G-protein coupled acetylcholine receptor signalingISSbiological_process
GO:2000344positive regulation of acrosome reactionISSbiological_process
GO:0046488phosphatidylinositol metabolic processISSbiological_process
GO:0035722interleukin-12-mediated signaling pathwayIDAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0045663positive regulation of myoblast differentiationIEAbiological_process
GO:0004435phosphatidylinositol phospholipase C activityISSmolecular_function
GO:0080154regulation of fertilizationISSbiological_process
GO:0045444fat cell differentiationIEAbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0060466activation of meiosis involved in egg activationIEAbiological_process
GO:2000560positive regulation of CD24 biosynthetic processISSbiological_process
GO:0040019positive regulation of embryonic developmentISSbiological_process
GO:0007613memoryISSbiological_process
GO:0008081phosphoric diester hydrolase activityIEAmolecular_function
GO:0008277regulation of G-protein coupled receptor protein sIEAbiological_process
GO:0021987cerebral cortex developmentIEAbiological_process
GO:0005516calmodulin bindingIPImolecular_function
GO:0043547positive regulation of GTPase activityIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0005521lamin bindingIEAmolecular_function
GO:0005546phosphatidylinositol-4,5-bisphosphate bindingIDAmolecular_function
GO:0046330positive regulation of JNK cascadeIDAbiological_process
GO:0032735positive regulation of interleukin-12 productionIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0048009insulin-like growth factor receptor signaling pathIEAbiological_process
GO:2000438negative regulation of monocyte extravasationIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0048009insulin-like growth factor receptor signaling pathISSbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:2000438negative regulation of monocyte extravasationISSbiological_process
GO:0060466activation of meiosis involved in egg activationISSbiological_process
GO:0048639positive regulation of developmental growthISSbiological_process
GO:0007165signal transductionNASbiological_process
GO:0040019positive regulation of embryonic developmentIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0016042lipid catabolic processIEAbiological_process
GO:0080154regulation of fertilizationIEAbiological_process
GO:0004435phosphatidylinositol phospholipase C activityIEAmolecular_function
GO:0045663positive regulation of myoblast differentiationISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0042803protein homodimerization activityISSmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0000790nuclear chromatinIEAcellular_component
GO:0000790nuclear chromatinISScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0070498interleukin-1-mediated signaling pathwayIDAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:2000560positive regulation of CD24 biosynthetic processIEAbiological_process
GO:0048639positive regulation of developmental growthIEAbiological_process
GO:0008277regulation of G-protein coupled receptor protein sISSbiological_process
GO:0007215glutamate receptor signaling pathwayISSbiological_process
GO:0035723interleukin-15-mediated signaling pathwayIDAbiological_process
GO:0007613memoryIEAbiological_process
GO:0016607nuclear speckIEAcellular_component
GO:0051318G1 phaseIEAbiological_process
GO:0005634nucleusNAScellular_component
GO:0021987cerebral cortex developmentISSbiological_process
GO:2000344positive regulation of acrosome reactionIEAbiological_process
GO:0032735positive regulation of interleukin-12 productionISSbiological_process
GO:0045892negative regulation of transcription, DNA-dependenISSbiological_process
GO:0000086G2/M transition of mitotic cell cycleISSbiological_process