| UniProt/SwissProt ID: | GNA15_HUMAN |
| Description: | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) [Source:HGNC Symbol;Acc:4383] |
| Location: | chr19 p13.3 |
| Node attribute: | Gprotein; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S336 | KKGARsRRLFS | PKCa | RegPhos |
| S336 | KKGARsRRLFS | G-alpha | PhosphoSitePlus |
| S336 | KKGARsRRLFS | PRKCA | HPRD |
| S336 | KKGARsRRLFS | PKC_group | phosphoELM; RegPhos |
| Dephosphorylation site |
| GNA15_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000262958 | E173K | COSMIC | Melanoma | 21499247 | ENSP00000262958 | P301S | COSMIC | Melanoma | 20424519 | ENSP00000262958 | R366C | COSMIC | Melanoma | 21499247 | ENSP00000262958 | E328K | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000262958 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.02 | 20198662 |
| Hyperphosphorylation site |
| GNA15_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNA15_HUMAN | TTC1_HUMAN | Gprotein -> effector | gpDB |
| GNA15_HUMAN | PLCB2_HUMAN | Gprotein -> effector | gpDB |
| GNA15_HUMAN | PLCB1_HUMAN | Gprotein -> effector | gpDB |
| GNA15_HUMAN | PLCB4_HUMAN | Gprotein -> effector | gpDB |
| GNA15_HUMAN | PLCB3_HUMAN | Gprotein -> effector | gpDB |
| GNA15_HUMAN | GRK6_HUMAN | Gprotein -> effector | gpDB |
| KPCA_HUMAN | GNA15_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05146 | Amoebiasis |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa04020 | Calcium signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003924 | GTPase activity | TAS | molecular_function |
| GO:0004871 | signal transducer activity | IGI | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0007202 | activation of phospholipase C activity | TAS | biological_process |
| GO:0031234 | extrinsic to internal side of plasma membrane | IBA | cellular_component |
| GO:0019001 | guanyl nucleotide binding | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0006471 | protein ADP-ribosylation | IEA | biological_process |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0007204 | elevation of cytosolic calcium ion concentration | IGI | biological_process |
| GO:0060158 | phospholipase C-activating dopamine receptor signa | IBA | biological_process |
| GO:0007204 | elevation of cytosolic calcium ion concentration | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007207 | phospholipase C-activating G-protein coupled acety | TAS | biological_process |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0001664 | G-protein coupled receptor binding | IBA | molecular_function |
| GO:0031683 | G-protein beta/gamma-subunit complex binding | IBA | molecular_function |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled rec | IBA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007200 | phospholipase C-activating G-protein coupled recep | IEA | biological_process |
| GO:0005834 | heterotrimeric G-protein complex | IBA | cellular_component |
| GO:0005525 | GTP binding | NAS | molecular_function |