Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SFRP1_HUMAN
Description:secreted frizzled-related protein 1 [Source:HGNC Symbol;Acc:10776]
Location:chr8 p11.21
Node attribute:PPI(source)

Phosphorylation site
SFRP1_HUMAN do not have phosphorylation site.

Dephosphorylation site
SFRP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000220772P119ACOSMICOvarian Cancer20826764
ENSP00000220772K295QCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000220772Breast CancerNormal vs. CancertissueDown20560667

Hyperphosphorylation site
SFRP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SFRP1_HUMANFZD10_HUMANotherKEGG
SFRP1_HUMANPLCB1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0021915neural tube developmentIEAbiological_process
GO:2000117negative regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0001649osteoblast differentiationIEPbiological_process
GO:0030097hemopoiesisIEAbiological_process
GO:0046546development of primary male sexual characteristicsIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0051894positive regulation of focal adhesion assemblyISSbiological_process
GO:0071392cellular response to estradiol stimulusIEPbiological_process
GO:0060527prostate epithelial cord arborization involved in IEAbiological_process
GO:0002244hematopoietic progenitor cell differentiationIDAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0045600positive regulation of fat cell differentiationIDAbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0005109frizzled bindingIPImolecular_function
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0060071Wnt receptor signaling pathway, planar cell polariIEAbiological_process
GO:2000270negative regulation of fibroblast apoptotic procesIDAbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0009267cellular response to starvationIEPbiological_process
GO:0009950dorsal/ventral axis specificationIDAbiological_process
GO:0071356cellular response to tumor necrosis factorIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0001954positive regulation of cell-matrix adhesionISSbiological_process
GO:0045578negative regulation of B cell differentiationIEAbiological_process
GO:0060218hematopoietic stem cell differentiationIDAbiological_process
GO:0045671negative regulation of osteoclast differentiationIEAbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0030279negative regulation of ossificationIDAbiological_process
GO:0006309apoptotic DNA fragmentationIDAbiological_process
GO:0045880positive regulation of smoothened signaling pathwaIMPbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0005622intracellularIDAcellular_component
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0030177positive regulation of Wnt receptor signaling pathIDAbiological_process
GO:0071363cellular response to growth factor stimulusIDAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIDAbiological_process
GO:0008584male gonad developmentIEAbiological_process
GO:0030165PDZ domain bindingIBAmolecular_function
GO:0004197cysteine-type endopeptidase activityIMPmolecular_function
GO:0090263positive regulation of canonical Wnt receptor signIDAbiological_process
GO:2000052positive regulation of non-canonical Wnt receptor IDAbiological_process
GO:0030307positive regulation of cell growthIDAbiological_process
GO:0050732negative regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0043508negative regulation of JUN kinase activityIEAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0090175regulation of establishment of planar polarityIEAbiological_process
GO:0008201heparin bindingIDAmolecular_function
GO:0045765regulation of angiogenesisISSbiological_process
GO:0022601menstrual cycle phaseIEPbiological_process
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:0009790embryo developmentIBAbiological_process
GO:0005886plasma membraneISScellular_component
GO:0005578proteinaceous extracellular matrixIDAcellular_component
GO:0071305cellular response to vitamin DIEPbiological_process
GO:0042493response to drugIDAbiological_process
GO:0008144drug bindingIDAmolecular_function
GO:0001843neural tube closureIEAbiological_process
GO:0044344cellular response to fibroblast growth factor stimIDAbiological_process
GO:2000080negative regulation of canonical Wnt receptor signIDAbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0045578negative regulation of B cell differentiationIMPbiological_process
GO:0090246convergent extension involved in somitogenesisIEAbiological_process
GO:0045668negative regulation of osteoblast differentiationIEAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIMPbiological_process
GO:0071347cellular response to interleukin-1IEPbiological_process
GO:0071456cellular response to hypoxiaIEPbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0060687regulation of branching involved in prostate glandIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIDAbiological_process
GO:0071560cellular response to transforming growth factor beIEPbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0071391cellular response to estrogen stimulusIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIDAbiological_process
GO:0051496positive regulation of stress fiber assemblyISSbiological_process
GO:0090179planar cell polarity pathway involved in neural tuIEAbiological_process
GO:0014034neural crest cell fate commitmentIEAbiological_process
GO:0017147Wnt-protein bindingIPImolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0030514negative regulation of BMP signaling pathwayIEAbiological_process
GO:0048147negative regulation of fibroblast proliferationIDAbiological_process
GO:0060346bone trabecula formationIEAbiological_process
GO:0071481cellular response to X-rayIEAbiological_process
GO:0060766negative regulation of androgen receptor signalingIDAbiological_process
GO:0046676negative regulation of insulin secretionIDAbiological_process
GO:0010719negative regulation of epithelial to mesenchymal tIDAbiological_process
GO:0008585female gonad developmentIEAbiological_process
GO:0090244Wnt receptor signaling pathway involved in somitogIEAbiological_process
GO:0010564regulation of cell cycle processIMPbiological_process
GO:0071773cellular response to BMP stimulusIEPbiological_process
GO:0008406gonad developmentIBAbiological_process
GO:0017147Wnt-protein bindingIEAmolecular_function
GO:2000271positive regulation of fibroblast apoptotic procesIDAbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0033689negative regulation of osteoblast proliferationIEAbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0071504cellular response to heparinIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030336negative regulation of cell migrationIDAbiological_process
GO:0030279negative regulation of ossificationIEAbiological_process
GO:2000041negative regulation of planar cell polarity pathwaIEAbiological_process
GO:0071391cellular response to estrogen stimulusIDAbiological_process
GO:2000054negative regulation of Wnt receptor signaling pathIDAbiological_process
GO:0046851negative regulation of bone remodelingIMPbiological_process
GO:0005829cytosolIDAcellular_component
GO:0014070response to organic cyclic compoundIDAbiological_process
GO:0033689negative regulation of osteoblast proliferationIMPbiological_process
GO:0032855positive regulation of Rac GTPase activityISSbiological_process
GO:0071380cellular response to prostaglandin E stimulusIEPbiological_process
GO:0048546digestive tract morphogenesisIEAbiological_process
GO:0007420brain developmentIBAbiological_process
GO:0010629negative regulation of gene expressionIDAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0001756somitogenesisIEAbiological_process
GO:0001944vasculature developmentIBAbiological_process
GO:0044345stromal-epithelial cell signaling involved in prosIEAbiological_process