Phosphorylation

Protein information

UniProt/SwissProt ID:	DTX1_HUMAN
Description:	deltex homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:3060]
Location:	chr12 q24.13
Node attribute:	substrate; ubiquitination(source)

Position	PhosphoPeptide	Source
S215	STRAAsNAILA	PhosphoSitePlus
S221	NAILAsQRRKA	PhosphoSitePlus
S279	GAPPRsPGAPG	PhosphoSitePlus

DTX1_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000257600	A598T	TCGA, COSMIC	Ovarian Cancer	21720365, 18772890
ENSP00000257600	M447I	COSMIC	Head and Neck Cancer	21798893
ENSP00000257600	V575A	COSMIC	Lung Cancer	20668451

DTX1_HUMAN is not differential expressed protein.

DTX1_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
NEK4_HUMAN	DTX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
DTX1_HUMAN	M3K1_HUMAN	ubiquitination	NetPath

KEGG Pathway

KEGG ID	Pathway
hsa04330	Notch signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0007166	cell surface receptor signaling pathway	TAS	biological_process
GO:0007219	Notch signaling pathway	IEA	biological_process
GO:0006366	transcription from RNA polymerase II promoter	TAS	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0003713	transcription coactivator activity	TAS	molecular_function
GO:0007219	Notch signaling pathway	TAS	biological_process
GO:0006351	transcription, DNA-dependent	NAS	biological_process
GO:0008270	zinc ion binding	IEA	molecular_function
GO:0017124	SH3 domain binding	IEA	molecular_function
GO:0045581	negative regulation of T cell differentiation	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0031625	ubiquitin protein ligase binding	IPI	molecular_function
GO:0008593	regulation of Notch signaling pathway	IGI	biological_process
GO:0016567	protein ubiquitination	IEA	biological_process
GO:0005737	cytoplasm	TAS	cellular_component
GO:0005112	Notch binding	IDA	molecular_function
GO:0045665	negative regulation of neuron differentiation	IGI	biological_process
GO:0005829	cytosol	TAS	cellular_component
GO:0010001	glial cell differentiation	IEA	biological_process
GO:0016874	ligase activity	IEA	molecular_function

Human Phosphorylation Mediated
Signaling Transduction Network