| UniProt/SwissProt ID: | TF2B_HUMAN |
| Description: | general transcription factor IIB [Source:HGNC Symbol;Acc:4648] |
| Location: | chr1 p22.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T123 | FKEITtMADRI | TFIIB | PhosphoSitePlus |
| S76 | QNPLLsDGDLS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S70 | SRVGDsQNPLL | PhosphoSitePlus | |
| Y293 | SYRLIyPRAPD | PhosphoSitePlus | |
| S65 | ATKDPsRVGDS | PhosphoSitePlus | |
| T270 | SAEKRtQKEIG | TFIIB; Sigma70_r4 | PhosphoSitePlus |
| T284 | GVADVtIRQSY | TFIIB; Sigma70_r4 | PhosphoSitePlus |
| Dephosphorylation site |
| TF2B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000359531 | R132Q | HPI | Colorectal Cancer | 16959974 | ENSP00000359531 | N139S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000359531 | R137* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000359531 | R132Q | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| TF2B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TF2B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK4_HUMAN | TF2B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | TF2B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TF2B_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0017025 | TBP-class protein binding | IEA | molecular_function |
| GO:0008134 | transcription factor binding | IPI | molecular_function |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0046966 | thyroid hormone receptor binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0006368 | transcription elongation from RNA polymerase II pr | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |