| UniProt/SwissProt ID: | CPSF3_HUMAN |
| Description: | cleavage and polyadenylation specific factor 3, 73kDa [Source:HGNC Symbol;Acc:2326] |
| Location: | chr2 p25.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T504 | DLSNYtDLAMS | PhosphoSitePlus | |
| T681 | LYEALtPVH__ | PhosphoSitePlus | |
| Y503 | CDLSNyTDLAM | PhosphoSitePlus | |
| T681 | LYEALtP | HPRD | |
| Y677 | AAQRLyEALTP | PhosphoSitePlus | |
| Y492 | KRNFNyHILSP | PhosphoSitePlus | |
| Dephosphorylation site |
| CPSF3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000238112 | H446Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000238112 | *685S | COSMIC | Breast Cancer | 16959974 | ENSP00000238112 | T346S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000238112 | D60Y | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000238112 | D578N | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000238112 | L201F | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| CPSF3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CPSF3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PK3C3_HUMAN | CPSF3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK4_HUMAN | CPSF3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| CPSF3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031124 | mRNA 3'-end processing | TAS | biological_process |
| GO:0006378 | mRNA polyadenylation | TAS | biological_process |
| GO:0016787 | hydrolase activity | IEA | molecular_function |
| GO:0004521 | endoribonuclease activity | IEA | molecular_function |
| GO:0005847 | mRNA cleavage and polyadenylation specificity fact | IDA | cellular_component |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0030529 | ribonucleoprotein complex | IEA | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006379 | mRNA cleavage | TAS | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006398 | histone mRNA 3'-end processing | IDA | biological_process |
| GO:0006406 | mRNA export from nucleus | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006369 | termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | biological_process |
| GO:0008409 | 5'-3' exonuclease activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006397 | mRNA processing | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |