| UniProt/SwissProt ID: | POGZ_HUMAN |
| Description: | pogo transposable element with ZNF domain [Source:HGNC Symbol;Acc:18801] |
| Location: | chr1 q21.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S274 | QLAVQsPGQSN | PhosphoSitePlus; HPRD; phosphoELM | |
| S1360 | EQLKLsGEHSE | PhosphoSitePlus; HPRD | |
| S651 | TVPVSsNDTPP | HPRD | |
| S440 | PKVATsFRCPH | HPRD | |
| S392 | PIPALsPPTKV | HPRD | |
| S1259 | PAGCSsKIQPL | HPRD | |
| S198 | SQQTKsTPSTS | HPRD | |
| S493 | PKVATsFRCPH | PhosphoSitePlus; HPRD | |
| S1313 | GEHSEsSTPRP | HPRD | |
| T205 | PSTSTtPTATQ | HPRD | |
| S437 | VASTPsSTPIP | PhosphoSitePlus | |
| T654 | VSSNDtPPSAL | HPRD | |
| T1368 | HSESStPRPRS | PhosphoSitePlus; HPRD; phosphoELM | |
| T229 | QSNQTtNPKLA | HPRD | |
| T435 | APVAStPSSTP | PhosphoSitePlus | |
| S1364 | LSGEHsESSTP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S425 | AAKPPsPEKTA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S221 | QLAVQsPGQSN | HPRD | |
| S746 | AVRKMsVMGRQ | PhosphoSitePlus | |
| T448 | ALSPPtKVPEP | PhosphoSitePlus; HPRD | |
| S1366 | GEHSEsSTPRP | PhosphoSitePlus; HPRD; phosphoELM | |
| T439 | STPSStPIPAL | PhosphoSitePlus | |
| Y33 | SVVEDyNSVDK | PhosphoSitePlus | |
| S251 | SQQTKsTPSTS | HPRD | |
| T686 | GLKPGtKVTIR | PhosphoSitePlus | |
| S1338 | DGNINsPTRNA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S416 | LDSEPsVPSAA | HPRD; phosphoELM | |
| S292 | APSFPsPPAVS | PhosphoSitePlus | |
| T1340 | NINSPtRNADM | PhosphoSitePlus | |
| S949 | DQDEGsPVTQE | PhosphoSitePlus | |
| T780 | LCRYStCCSRA | PhosphoSitePlus | |
| T707 | VSSNDtPPSAL | PhosphoSitePlus; HPRD; phosphoELM | |
| S1206 | PAGCSsKIQPL | HPRD | |
| S1352 | EELIAsLEEQL | PhosphoSitePlus | |
| T429 | PSPEKtAPVAS | PhosphoSitePlus; HPRD; phosphoELM | |
| T492 | FPKVAtSFRCP | PhosphoSitePlus; HPRD | |
| S1236 | HRTHLsEEVLA | HPRD | |
| S1169 | TACQRsKGMLV | HPRD | |
| T1315 | HSESStPRPRS | HPRD | |
| S419 | EPSVPsAAKPP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S1311 | LSGEHsESSTP | HPRD | |
| S333 | PSLGQsPGPVV | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S704 | TVPVSsNDTPP | PhosphoSitePlus; HPRD | |
| S434 | TAPVAsTPSST | PhosphoSitePlus | |
| T689 | PGTKVtIRASR | PhosphoSitePlus | |
| S445 | PIPALsPPTKV | PhosphoSitePlus; HPRD; phosphoELM | |
| T258 | PSTSTtPTATQ | PhosphoSitePlus; HPRD | |
| S363 | LDSEPsVPSAA | HPRD | |
| S1367 | EHSESsTPRPR | PhosphoSitePlus; phosphoELM | |
| T395 | ALSPPtKVPEP | HPRD | |
| S1222 | TACQRsKGMLV | HPRD | |
| S1183 | HRTHLsEEVLA | HPRD | |
| S366 | EPSVPsAAKPP | HPRD | |
| S280 | PSLGQsPGPVV | HPRD | |
| S1013 | RRFQAsQGENL | HTH_28 | PhosphoSitePlus |
| T439 | FPKVAtSFRCP | HPRD | |
| S1285 | DGNINsPTRNA | HPRD | |
| S1307 | EQLKLsGEHSE | HPRD | |
| S372 | AAKPPsPEKTA | HPRD | |
| T282 | QSNQTtNPKLA | HPRD | |
| T376 | PSPEKtAPVAS | HPRD | |
| Dephosphorylation site |
| POGZ_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000357856 | D317H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000271715 | G192D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000418408 | D359H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000376484 | D359H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000354467 | D359H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000271715 | A568S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000271715 | D412H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000418408 | A515S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000357856 | A473S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000376484 | A515S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000271715 | G1167C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000271715 | L235V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000354467 | A515S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000271715 | R1087* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| POGZ_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| POGZ_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK4_HUMAN | POGZ_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| POGZ_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0051382 | kinetochore assembly | IMP | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000790 | nuclear chromatin | IDA | cellular_component |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0007064 | mitotic sister chromatid cohesion | IMP | biological_process |