Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MP2K6_HUMAN
Description:mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:6846]
Location:chr17 q24.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S27QPQTSsTPPRDPhosphoSitePlus
S90RATVNsQEQKRPkinasePhosphoSitePlus
S207GYLVDsVAKTIphosphoELM
Y64LGRGAyGVVEKPkinasePhosphoSitePlus
T211DSVAKtIDAGCphosphoELM
Y219AGCKPyMAPERPkinasePhosphoSitePlus
T28PQTSStPPRDLPhosphoSitePlus; phosphoELM; SysPTM
S201CDFGIsGYLVDPkinasePhosphoSitePlus
T25FEQPQtSSTPPphosphoELM
S207GYLVDsVAKTIPkinasePhosphoSitePlus
T211DSVAKtIDAGCPkinasePhosphoSitePlus
S35EAFEQPQTSSTPPRDLDSKSysPTM 2.0

Dephosphorylation site
MP2K6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000351997V163GTCGAOvarian Cancer21720365, 18772890
ENSP00000351997M1RBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000351997Lung CancerCancer vs. Cancercell lineUp17284061

Hyperphosphorylation site
MP2K6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MP2K6_HUMANMK13_HUMANkinase -> substrateHPRD; RegPhos
M3K5_HUMANMP2K6_HUMANkinase -> substrateKEGG
M3K7_HUMANMP2K6_HUMANkinase -> substrateKEGG; NetPath
MP2K6_HUMANRUVB1_HUMANkinase -> substrateRobert H Newman (2013)
M3K6_HUMANMP2K6_HUMANkinase -> substrateKEGG
MP2K6_HUMANMK12_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MP2K6_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
MP2K6_HUMANMK14_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MP2K6_HUMANPAK6_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MP2K6_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
MP2K6_HUMANT22D3_HUMANkinase -> substrateRobert H Newman (2013)
MP2K6_HUMANSTAT4_HUMANkinase -> substrateHPRD; RegPhos
PPM1A_HUMANMP2K6_HUMANphosphatase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04912GnRH signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05145Toxoplasmosis
hsa04010MAPK signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa05164Influenza A
hsa05169Epstein-Barr virus infection
hsa04620Toll-like receptor signaling pathway
hsa04380Osteoclast differentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0006975DNA damage induced protein phosphorylationTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0007050cell cycle arrestTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0004708MAP kinase kinase activityTASmolecular_function
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0051149positive regulation of muscle cell differentiationTASbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0007165signal transductionTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0042692muscle cell differentiationTASbiological_process


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