| UniProt/SwissProt ID: | MP2K6_HUMAN |
| Description: | mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:6846] |
| Location: | chr17 q24.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S27 | QPQTSsTPPRD | PhosphoSitePlus | |
| S90 | RATVNsQEQKR | Pkinase | PhosphoSitePlus |
| S207 | GYLVDsVAKTI | phosphoELM | |
| Y64 | LGRGAyGVVEK | Pkinase | PhosphoSitePlus |
| T211 | DSVAKtIDAGC | phosphoELM | |
| Y219 | AGCKPyMAPER | Pkinase | PhosphoSitePlus |
| T28 | PQTSStPPRDL | PhosphoSitePlus; phosphoELM; SysPTM | |
| S201 | CDFGIsGYLVD | Pkinase | PhosphoSitePlus |
| T25 | FEQPQtSSTPP | phosphoELM | |
| S207 | GYLVDsVAKTI | Pkinase | PhosphoSitePlus |
| T211 | DSVAKtIDAGC | Pkinase | PhosphoSitePlus |
| S35 | EAFEQPQTSSTPPRDLDSK | SysPTM 2.0 | |
| Dephosphorylation site |
| MP2K6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000351997 | V163G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000351997 | M1R | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000351997 | Lung Cancer | Cancer vs. Cancer | cell line | Up | 17284061 | |
| Hyperphosphorylation site |
| MP2K6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MP2K6_HUMAN | MK13_HUMAN | kinase -> substrate | HPRD; RegPhos |
| M3K5_HUMAN | MP2K6_HUMAN | kinase -> substrate | KEGG |
| M3K7_HUMAN | MP2K6_HUMAN | kinase -> substrate | KEGG; NetPath |
| MP2K6_HUMAN | RUVB1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K6_HUMAN | MP2K6_HUMAN | kinase -> substrate | KEGG |
| MP2K6_HUMAN | MK12_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MP2K6_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K6_HUMAN | MK14_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MP2K6_HUMAN | PAK6_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MP2K6_HUMAN | KPCD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K6_HUMAN | T22D3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K6_HUMAN | STAT4_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PPM1A_HUMAN | MP2K6_HUMAN | phosphatase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04912 | GnRH signaling pathway |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| hsa05145 | Toxoplasmosis |
| hsa04010 | MAPK signaling pathway |
| hsa04664 | Fc epsilon RI signaling pathway |
| hsa05164 | Influenza A |
| hsa05169 | Epstein-Barr virus infection |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04380 | Osteoclast differentiation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0034134 | toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0006975 | DNA damage induced protein phosphorylation | TAS | biological_process |
| GO:0051403 | stress-activated MAPK cascade | TAS | biological_process |
| GO:0007050 | cell cycle arrest | TAS | biological_process |
| GO:0034130 | toll-like receptor 1 signaling pathway | TAS | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0035872 | nucleotide-binding domain, leucine rich repeat con | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034138 | toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0004708 | MAP kinase kinase activity | TAS | molecular_function |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathwa | TAS | biological_process |
| GO:0008063 | Toll signaling pathway | TAS | biological_process |
| GO:0002224 | toll-like receptor signaling pathway | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0070423 | nucleotide-binding oligomerization domain containi | TAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathw | TAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0051149 | positive regulation of muscle cell differentiation | TAS | biological_process |
| GO:0000187 | activation of MAPK activity | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0002756 | MyD88-independent toll-like receptor signaling pat | TAS | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0042692 | muscle cell differentiation | TAS | biological_process |