| UniProt/SwissProt ID: | M3K6_HUMAN |
| Description: | mitogen-activated protein kinase kinase kinase 6 [Source:HGNC Symbol;Acc:6858] |
| Location: | chr1 p36.11 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T801 | RLAGItPCTET | PhosphoSitePlus | |
| S896 | PRLRAsAQTLL | PhosphoSitePlus | |
| S964 | PKRCLsYGGTS | PhosphoSitePlus; HPRD | |
| S367 | DMFFSsGFQDA | PhosphoSitePlus | |
| T806 | TPCTEtFTGTL | MAP3K6 | HPRD |
| S912 | QPGKRsRSPSS | HPRD | |
| S1149 | SPGQQsPLPVE | PhosphoSitePlus | |
| T899 | RASAQtLLGDP | PhosphoSitePlus | |
| T806 | TPCTEtFTGTL | PhosphoSitePlus | |
| S1281 | AQRAGsTPVTS | PhosphoSitePlus | |
| S914 | GKRSRsPSSPR | HPRD | |
| S1129 | EKEAVsPRSEE | PhosphoSitePlus; HPRD | |
| Y717 | ASQGGyLKIFM | PhosphoSitePlus | |
| S984 | AEEPAsPEESS | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| M3K6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363152 | P950T | COSMIC | Gastric Cancer | 21097718 | ENSP00000363152 | R367Q | COSMIC | Gastric Cancer | 21097718 | ENSP00000419591 | S925L | HPI | Breast Cancer | 17344846 | ENSP00000350195 | P228R | Ding2008 | Lung Cancer | 18948947 | ENSP00000350195 | P869T | Sjoblom2006, HPI, BIOMART | Breast Cancer | 16959974, 21930507, 21930502 | ENSP00000350195 | S925L | HPI | Breast Cancer | 17344846 | ENSP00000363152 | A203V | COSMIC | Skin Cancer | 21984974 | ENSP00000419591 | P869T | HPI | Breast Cancer | 16959974 | ENSP00000350195 | T968I | HPI | Ovarian Cancer | 17344846 | ENSP00000350195 | L811V | Ding2008 | Lung Cancer | 18948947 | ENSP00000419591 | T968I | HPI | Ovarian Cancer | 17344846 | ENSP00000363152 | R953C | COSMIC | Central Nervous System Neoplasms | 21817013 |
| Differential expressed protein |
| M3K6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| M3K6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| M3K6_HUMAN | M3K6_HUMAN | kinase -> substrate | HPRD |
| M3K6_HUMAN | MP2K3_HUMAN | kinase -> substrate | KEGG |
| M3K6_HUMAN | MP2K6_HUMAN | kinase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0007257 | activation of JUN kinase activity | TAS | biological_process |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0000186 | activation of MAPKK activity | IDA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IDA | molecular_function |