Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K6_HUMAN
Description:mitogen-activated protein kinase kinase kinase 6 [Source:HGNC Symbol;Acc:6858]
Location:chr1 p36.11
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T801RLAGItPCTETPhosphoSitePlus
S896PRLRAsAQTLLPhosphoSitePlus
S964PKRCLsYGGTSPhosphoSitePlus; HPRD
S367DMFFSsGFQDAPhosphoSitePlus
T806TPCTEtFTGTLMAP3K6HPRD
S912QPGKRsRSPSSHPRD
S1149SPGQQsPLPVEPhosphoSitePlus
T899RASAQtLLGDPPhosphoSitePlus
T806TPCTEtFTGTLPhosphoSitePlus
S1281AQRAGsTPVTSPhosphoSitePlus
S914GKRSRsPSSPRHPRD
S1129EKEAVsPRSEEPhosphoSitePlus; HPRD
Y717ASQGGyLKIFMPhosphoSitePlus
S984AEEPAsPEESSPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
M3K6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363152P950TCOSMICGastric Cancer21097718
ENSP00000363152R367QCOSMICGastric Cancer21097718
ENSP00000419591S925LHPIBreast Cancer17344846
ENSP00000350195P228RDing2008Lung Cancer18948947
ENSP00000350195P869TSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502
ENSP00000350195S925LHPIBreast Cancer17344846
ENSP00000363152A203VCOSMICSkin Cancer21984974
ENSP00000419591P869THPIBreast Cancer16959974
ENSP00000350195T968IHPIOvarian Cancer17344846
ENSP00000350195L811VDing2008Lung Cancer18948947
ENSP00000419591T968IHPIOvarian Cancer17344846
ENSP00000363152R953CCOSMICCentral Nervous System Neoplasms21817013

Differential expressed protein
M3K6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K6_HUMANM3K6_HUMANkinase -> substrateHPRD
M3K6_HUMANMP2K3_HUMANkinase -> substrateKEGG
M3K6_HUMANMP2K6_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0007257activation of JUN kinase activityTASbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0000186activation of MAPKK activityIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004709MAP kinase kinase kinase activityIDAmolecular_function


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