| UniProt/SwissProt ID: | TYRP2_HUMAN |
| Description: | dopachrome tautomerase [Source:HGNC Symbol;Acc:2709] |
| Location: | chr13 q32.1 |
| Node attribute: | gene |
| Phosphorylation site |
| TYRP2_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| TYRP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000366227 | A491V | COSMIC | Pancreatic Cancer | ENSP00000366227 | G305D | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000366227 | Y303C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000366227 | R83H | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000366227 | R65P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000366227 | L145F | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| TYRP2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TYRP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MITF_HUMAN | TYRP2_HUMAN | TF -> target gene | TRANSFAC |
| LEF1_HUMAN | TYRP2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| TYRP2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006583 | melanin biosynthetic process from tyrosine | ISS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0048066 | developmental pigmentation | IEA | biological_process |
| GO:0048468 | cell development | IEA | biological_process |
| GO:0006583 | melanin biosynthetic process from tyrosine | IEA | biological_process |
| GO:0042438 | melanin biosynthetic process | IEA | biological_process |
| GO:0043473 | pigmentation | IEA | biological_process |
| GO:0016491 | oxidoreductase activity | IEA | molecular_function |
| GO:0033162 | melanosome membrane | IEA | cellular_component |
| GO:0004167 | dopachrome isomerase activity | IEA | molecular_function |
| GO:0042470 | melanosome | ISS | cellular_component |
| GO:0021847 | ventricular zone neuroblast division | IEA | biological_process |
| GO:0042470 | melanosome | IEA | cellular_component |
| GO:0005507 | copper ion binding | TAS | molecular_function |
| GO:0008152 | metabolic process | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004167 | dopachrome isomerase activity | ISS | molecular_function |
| GO:0005829 | cytosol | ISS | cellular_component |
| GO:0002052 | positive regulation of neuroblast proliferation | IEA | biological_process |
| GO:0008544 | epidermis development | TAS | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |