Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SUIS_HUMAN
Description:sucrase-isomaltase (alpha-glucosidase) [Source:HGNC Symbol;Acc:10856]
Location:chr3 q26.1
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1592YTLLPyFYTQMGlyco_hydro_31PhosphoSitePlus
T996SSMGItADLQLPhosphoSitePlus
Y190VSDTLyDVKVAPhosphoSitePlus
Y562DVHSLyGYSMAGlyco_hydro_31PhosphoSitePlus
S7LEISPRKACAHPRD
S7ARKKFsGLEISPKACaRegPhos
T51STPATtRVTTNPhosphoSitePlus
S984QDNSYsVNSARPhosphoSitePlus
S987SYSVNsARYSSPhosphoSitePlus
Y1587ILNIRyTLLPYGlyco_hydro_31PhosphoSitePlus
Y540LDKLMySKTICGlyco_hydro_31PhosphoSitePlus
S1771ETRLGsLHVWGPhosphoSitePlus
S991NSARYsSMGITPhosphoSitePlus
S7LEISPKA_groupphosphoELM
T1003DLQLNtANARIPhosphoSitePlus
Y983RQDNSySVNSAPhosphoSitePlus
S7ARKKFsGLEISPKA_groupRegPhos

Dephosphorylation site
SUIS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264382I1378NCOSMICSkin Cancer21984974
ENSP00000264382V342ICOSMICHead and Neck Cancer21798897
ENSP00000264382Q410RCOSMICOvarian Cancer21720365
ENSP00000264382I1034FCOSMICOvarian Cancer21720365
ENSP00000264382L1683ICOSMICHead and Neck Cancer21798893
ENSP00000264382Q1101KCOSMICOvarian Cancer21720365
ENSP00000264382G815VCOSMICHead and Neck Cancer21798893
ENSP00000264382Q1694*BIOMARTBreast Cancer21930507, 21930502
ENSP00000264382R596SCOSMICHead and Neck Cancer21798893
ENSP00000264382D1664YCOSMICHead and Neck Cancer21798893
ENSP00000264382E889KCOSMICHead and Neck Cancer21984974
ENSP00000264382A442TCOSMICCentral Nervous System Neoplasms21817013
ENSP00000264382K206NCOSMICOvarian Cancer21720365
ENSP00000264382T211ICOSMICOvarian Cancer21720365
ENSP00000264382T1307ACOSMICHead and Neck Cancer21798893
ENSP00000264382W552CBIOMARTBreast Cancer21930507, 21930502
ENSP00000264382P1202TCOSMICOvarian Cancer21720365
ENSP00000264382R169KCOSMICHead and Neck Cancer21798893
ENSP00000264382D1664VBIOMARTBreast Cancer21930507, 21930502
ENSP00000264382T1017NCOSMICOvarian Cancer21720365
ENSP00000264382E10QBIOMARTBreast Cancer21930507, 21930502
ENSP00000264382G1287RCOSMICHead and Neck Cancer21798897
ENSP00000264382G1669*COSMICHead and Neck Cancer21798897
ENSP00000264382L1167*COSMICHead and Neck Cancer21798897
ENSP00000264382V1239FCOSMICOvarian Cancer21720365
ENSP00000264382R250CCOSMICOvarian Cancer21720365

Differential expressed protein
SUIS_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SUIS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANSUIS_HUMANkinase -> substrateHPRD
MITF_HUMANSUIS_HUMANTF -> target geneTRANSFAC
HNF1B_HUMANSUIS_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANSUIS_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00500Starch and sucrose metabolism
hsa00052Galactose metabolism
hsa04973Carbohydrate digestion and absorption
hsa01100Metabolic pathways

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004558alpha-glucosidase activityTASmolecular_function
GO:0004574oligo-1,6-glucosidase activityIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0030246carbohydrate bindingIEAmolecular_function
GO:0044245polysaccharide digestionTASbiological_process
GO:0005903brush borderTAScellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounIEAmolecular_function
GO:0016324apical plasma membraneIEAcellular_component
GO:0004575sucrose alpha-glucosidase activityTASmolecular_function
GO:0005794Golgi apparatusTAScellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0003824catalytic activityIEAmolecular_function


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