| UniProt/SwissProt ID: | SUIS_HUMAN |
| Description: | sucrase-isomaltase (alpha-glucosidase) [Source:HGNC Symbol;Acc:10856] |
| Location: | chr3 q26.1 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1592 | YTLLPyFYTQM | Glyco_hydro_31 | PhosphoSitePlus |
| T996 | SSMGItADLQL | PhosphoSitePlus | |
| Y190 | VSDTLyDVKVA | PhosphoSitePlus | |
| Y562 | DVHSLyGYSMA | Glyco_hydro_31 | PhosphoSitePlus |
| S7 | LEIS | PRKACA | HPRD |
| S7 | ARKKFsGLEIS | PKACa | RegPhos |
| T51 | STPATtRVTTN | PhosphoSitePlus | |
| S984 | QDNSYsVNSAR | PhosphoSitePlus | |
| S987 | SYSVNsARYSS | PhosphoSitePlus | |
| Y1587 | ILNIRyTLLPY | Glyco_hydro_31 | PhosphoSitePlus |
| Y540 | LDKLMySKTIC | Glyco_hydro_31 | PhosphoSitePlus |
| S1771 | ETRLGsLHVWG | PhosphoSitePlus | |
| S991 | NSARYsSMGIT | PhosphoSitePlus | |
| S7 | LEIS | PKA_group | phosphoELM |
| T1003 | DLQLNtANARI | PhosphoSitePlus | |
| Y983 | RQDNSySVNSA | PhosphoSitePlus | |
| S7 | ARKKFsGLEIS | PKA_group | RegPhos |
| Dephosphorylation site |
| SUIS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264382 | I1378N | COSMIC | Skin Cancer | 21984974 | ENSP00000264382 | V342I | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000264382 | Q410R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264382 | I1034F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264382 | L1683I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264382 | Q1101K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264382 | G815V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264382 | Q1694* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264382 | R596S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264382 | D1664Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264382 | E889K | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000264382 | A442T | COSMIC | Central Nervous System Neoplasms | 21817013 | ENSP00000264382 | K206N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264382 | T211I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264382 | T1307A | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264382 | W552C | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264382 | P1202T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264382 | R169K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264382 | D1664V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264382 | T1017N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264382 | E10Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264382 | G1287R | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000264382 | G1669* | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000264382 | L1167* | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000264382 | V1239F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264382 | R250C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| SUIS_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SUIS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | SUIS_HUMAN | kinase -> substrate | HPRD |
| MITF_HUMAN | SUIS_HUMAN | TF -> target gene | TRANSFAC |
| HNF1B_HUMAN | SUIS_HUMAN | TF -> target gene | TRANSFAC |
| HNF1A_HUMAN | SUIS_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00500 | Starch and sucrose metabolism |
| hsa00052 | Galactose metabolism |
| hsa04973 | Carbohydrate digestion and absorption |
| hsa01100 | Metabolic pathways |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004558 | alpha-glucosidase activity | TAS | molecular_function |
| GO:0004574 | oligo-1,6-glucosidase activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0030246 | carbohydrate binding | IEA | molecular_function |
| GO:0044245 | polysaccharide digestion | TAS | biological_process |
| GO:0005903 | brush border | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compoun | IEA | molecular_function |
| GO:0016324 | apical plasma membrane | IEA | cellular_component |
| GO:0004575 | sucrose alpha-glucosidase activity | TAS | molecular_function |
| GO:0005794 | Golgi apparatus | TAS | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0003824 | catalytic activity | IEA | molecular_function |