Phosphorylation

Protein information

UniProt/SwissProt ID:	TYRO_HUMAN
Description:	tyrosinase [Source:HGNC Symbol;Acc:12442]
Location:	chr11 q14.3
Node attribute:	gene

Position	PhosphoPeptide	Source
S523	KEDYHsLYQSH	PhosphoSitePlus
S527	HSLYQsHL___	PhosphoSitePlus

TYRO_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000263321	K33N	BIOMART	Pancreatic Cancer	21930507, 21930502
ENSP00000263321	E510K	COSMIC	Skin Cancer	21984974
ENSP00000263321	Y156*	BIOMART	Hepatocellular Carcinoma	21930507, 21930502
ENSP00000263321	D317A	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000263321	T292M	COSMIC	Head and Neck Cancer	21798893
ENSP00000263321	D356E	COSMIC	Head and Neck Cancer	21798893
ENSP00000263321	D317A	COSMIC	Ovarian Cancer	21720365

TYRO_HUMAN is not differential expressed protein.

TYRO_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
MITF_HUMAN	TYRO_HUMAN	TF -> target gene	TRANSFAC
USF1_HUMAN	TYRO_HUMAN	TF -> target gene	TRANSFAC

KEGG Pathway

TYRO_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0008152	metabolic process	IEA	biological_process
GO:0048471	perinuclear region of cytoplasm	IDA	cellular_component
GO:0004503	monophenol monooxygenase activity	IEA	molecular_function
GO:0005737	cytoplasm	IDA	cellular_component
GO:0006583	melanin biosynthetic process from tyrosine	TAS	biological_process
GO:0046982	protein heterodimerization activity	ISS	molecular_function
GO:0004503	monophenol monooxygenase activity	IDA	molecular_function
GO:0007601	visual perception	TAS	biological_process
GO:0005507	copper ion binding	IMP	molecular_function
GO:0016491	oxidoreductase activity	IEA	molecular_function
GO:0042470	melanosome	IEA	cellular_component
GO:0043473	pigmentation	IEA	biological_process
GO:0042803	protein homodimerization activity	ISS	molecular_function
GO:0008283	cell proliferation	IEA	biological_process
GO:0042470	melanosome	ISS	cellular_component
GO:0033162	melanosome membrane	IEA	cellular_component
GO:0016021	integral to membrane	IEA	cellular_component
GO:0005515	protein binding	IEA	molecular_function
GO:0042803	protein homodimerization activity	IEA	molecular_function
GO:0048538	thymus development	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0042438	melanin biosynthetic process	IEA	biological_process
GO:0005764	lysosome	TAS	cellular_component
GO:0005798	Golgi-associated vesicle	TAS	cellular_component
GO:0046982	protein heterodimerization activity	IEA	molecular_function
GO:0006726	eye pigment biosynthetic process	TAS	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network