Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TYRO_HUMAN
Description:tyrosinase [Source:HGNC Symbol;Acc:12442]
Location:chr11 q14.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S523KEDYHsLYQSHPhosphoSitePlus
S527HSLYQsHL___PhosphoSitePlus

Dephosphorylation site
TYRO_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263321K33NBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000263321E510KCOSMICSkin Cancer21984974
ENSP00000263321Y156*BIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000263321D317ATCGAOvarian Cancer21720365, 18772890
ENSP00000263321T292MCOSMICHead and Neck Cancer21798893
ENSP00000263321D356ECOSMICHead and Neck Cancer21798893
ENSP00000263321D317ACOSMICOvarian Cancer21720365

Differential expressed protein
TYRO_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TYRO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MITF_HUMANTYRO_HUMANTF -> target geneTRANSFAC
USF1_HUMANTYRO_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TYRO_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008152metabolic processIEAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0004503monophenol monooxygenase activityIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006583melanin biosynthetic process from tyrosineTASbiological_process
GO:0046982protein heterodimerization activityISSmolecular_function
GO:0004503monophenol monooxygenase activityIDAmolecular_function
GO:0007601visual perceptionTASbiological_process
GO:0005507copper ion bindingIMPmolecular_function
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0042470melanosomeIEAcellular_component
GO:0043473pigmentationIEAbiological_process
GO:0042803protein homodimerization activityISSmolecular_function
GO:0008283cell proliferationIEAbiological_process
GO:0042470melanosomeISScellular_component
GO:0033162melanosome membraneIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0048538thymus developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042438melanin biosynthetic processIEAbiological_process
GO:0005764lysosomeTAScellular_component
GO:0005798Golgi-associated vesicleTAScellular_component
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0006726eye pigment biosynthetic processTASbiological_process


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