| UniProt/SwissProt ID: | MMP7_HUMAN |
| Description: | matrix metallopeptidase 7 (matrilysin, uterine) [Source:HGNC Symbol;Acc:7174] |
| Location: | chr11 q22.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S47 | FYLYDsETKNA | PG_binding_1 | PhosphoSitePlus |
| T49 | LYDSEtKNANS | PG_binding_1 | PhosphoSitePlus |
| Dephosphorylation site |
| MMP7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000260227 | V114I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000260227 | L6M | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000260227 | Uterine Cancer | Normal vs. Cancer | cell line | Up | 1900 | 15838902 | ENSP00000260227 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 1.6 | 19199705 |
| Hyperphosphorylation site |
| MMP7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LEF1_HUMAN | MMP7_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04310 | Wnt signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050829 | defense response to Gram-negative bacterium | IEA | biological_process |
| GO:0005615 | extracellular space | TAS | cellular_component |
| GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0030198 | extracellular matrix organization | TAS | biological_process |
| GO:0031012 | extracellular matrix | IEA | cellular_component |
| GO:0042742 | defense response to bacterium | IEA | biological_process |
| GO:0004222 | metalloendopeptidase activity | IEA | molecular_function |
| GO:0030574 | collagen catabolic process | IEA | biological_process |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0008237 | metallopeptidase activity | IEA | molecular_function |
| GO:0022617 | extracellular matrix disassembly | TAS | biological_process |
| GO:0002779 | antibacterial peptide secretion | IEA | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0042127 | regulation of cell proliferation | IEA | biological_process |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0050830 | defense response to Gram-positive bacterium | IEA | biological_process |