Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HDAC9_HUMAN
Description:histone deacetylase 9 [Source:HGNC Symbol;Acc:14065]
Location:chr7 p21.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S422PLHPQsPLATKPhosphoSitePlus
S220LRKTAsEPNLKPhosphoSitePlus
S451LNRTQsAPLPQPhosphoSitePlus
T449RPLNRtQSAPLPhosphoSitePlus
S253GNVVTsFKKRMPhosphoSitePlus
Y1010EIQSKyWKSVRHPRD
S240AERRSsPLLRRPhosphoSitePlus
Y1007EIQSKyWKSVRHPRD
S239VAERRsSPLLRPhosphoSitePlus
T426QSPLAtKERISPhosphoSitePlus
S22GLEPIsPLDLRPhosphoSitePlus

Dephosphorylation site
HDAC9_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000408617P924TCOSMICRenal Cancer21248752
ENSP00000408617G17SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000408617S532RCOSMICLung Cancer
ENSP00000408617N283DCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
HDAC9_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HDAC9_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD1_HUMANHDAC9_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05034Alcoholism
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032869cellular response to insulin stimulusIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0034983peptidyl-lysine deacetylationIDAbiological_process
GO:0070491repressing transcription factor bindingIEAmolecular_function
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 IEAmolecular_function
GO:0051153regulation of striated muscle cell differentiationIEAbiological_process
GO:0032041NAD-dependent histone deacetylase activity (H3-K14IEAmolecular_function
GO:0033558protein deacetylase activityIDAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0016575histone deacetylationIDAbiological_process
GO:0005667transcription factor complexIDAcellular_component
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0048742regulation of skeletal muscle fiber developmentIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0097372NAD-dependent histone deacetylase activity (H3-K18IEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0042113B cell activationTASbiological_process
GO:0016568chromatin modificationIEAbiological_process
GO:0005080protein kinase C bindingIPImolecular_function
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0035097histone methyltransferase complexIEAcellular_component
GO:0004407histone deacetylase activityIDAmolecular_function
GO:0090050positive regulation of cell migration involved in IMPbiological_process
GO:0051153regulation of striated muscle cell differentiationISSbiological_process
GO:0000118histone deacetylase complexTAScellular_component
GO:0030183B cell differentiationTASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0070932histone H3 deacetylationIDAbiological_process
GO:0046970NAD-dependent histone deacetylase activity (H4-K16IEAmolecular_function
GO:0005634nucleusNAScellular_component
GO:0070933histone H4 deacetylationIDAbiological_process
GO:0003714transcription corepressor activityIEAmolecular_function


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