Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPAS1_HUMAN
Description:endothelial PAS domain protein 1 [Source:HGNC Symbol;Acc:3374]
Location:chr2 p21
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S11EKKRSsSERRKPhosphoSitePlus
S795SPGENsKSRFPPhosphoSitePlus
Y307VVSGQyRMLAKPAS_3PhosphoSitePlus
S12KKRSSsERRKEPhosphoSitePlus
S10KEKKRsSSERRPhosphoSitePlus
T324LETQGtVIYNPPRKD1HPRD
T182TNRGRtVNLKSPASPhosphoSitePlus
T324LETQGtVIYNPPAS_3PhosphoSitePlus

Dephosphorylation site
EPAS1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263734E502KCOSMICSkin Cancer21984974
ENSP00000263734P791LCOSMICMelanoma
ENSP00000263734N483SCOSMICOvarian Cancer21720365
ENSP00000263734R710*BIOMARTBreast Cancer21930507, 21930502
ENSP00000263734N483STCGAOvarian Cancer21720365, 18772890
ENSP00000263734R144CCOSMICHead and Neck Cancer21798893

Differential expressed protein
EPAS1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EPAS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD1_HUMANEPAS1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0048625myoblast cell fate commitmentIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0007005mitochondrion organizationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0042415norepinephrine metabolic processIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0008134transcription factor bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0002027regulation of heart rateIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0030097hemopoiesisIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0061418regulation of transcription from RNA polymerase IITASbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0035035histone acetyltransferase bindingIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyIGIbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005667transcription factor complexIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0071456cellular response to hypoxiaTASbiological_process
GO:0048469cell maturationIEAbiological_process
GO:0043129surfactant homeostasisIEAbiological_process
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0007601visual perceptionIEAbiological_process
GO:0033554cellular response to stressTASbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0043619regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0001666response to hypoxiaIDAbiological_process


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