Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HDAC5_HUMAN
Description:histone deacetylase 5 [Source:HGNC Symbol;Acc:14068]
Location:chr17 q21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S798NEMHSsSAVRMHist_deacetylPhosphoSitePlus
S206GGLNHsLPQHPPhosphoSitePlus
T546LPRQPtTHPEEPhosphoSitePlus
S498LSRTQsSPLPQPKD1RegPhos
S498LSRTQsSPLPQCAMK1HPRD
S7NSPNEsDGMSGPhosphoSitePlus
S259LRKTAsEPNLKCaMK_groupRegPhos
S499SRTQSsPLPQSPKD1RegPhos
S671PGGMKsPPDQPPhosphoSitePlus
S260LRKTAsEPNLKCAMK1HPRD
S498LSRTQsSPLPQPRKD1HPRD
S279AERRSsPLLRRPhosphoSitePlus
S368LYTSPsLPNISPhosphoSitePlus
S259LRKTAsEPNLKCaM-KIVphosphoELM
Y776ISQKMyAVLPCHist_deacetylPhosphoSitePlus
S661LGRTQsSPAAPPhosphoSitePlus
S611DEEGEsGAEEGPhosphoSitePlus
S498LSRTQsSPLPQCaMK_groupRegPhos
S260LRKTAsEPNLKPRKD1HPRD
S180ESAIAsTEVKLPhosphoSitePlus
S504SPLPQsPQALQPhosphoSitePlus
S499LSRTQsSPLPQPRKD1HPRD
S499SRTQSsPLPQSCaMK1aRegPhos
S278VAERRsSPLLRPhosphoSitePlus
S259LRKTAsEPNLKPKD1RegPhos
S799EMHSSsAVRMAHist_deacetylPhosphoSitePlus
S53GGGGGsPSPVEPhosphoSitePlus
S259LRKTAsEPNLKPhosphoSitePlus
T288RRKDGtVISTFPhosphoSitePlus
T181SAIAStEVKLRPhosphoSitePlus
S498LSRTQsSPLPQCaM-KIVphosphoELM
S259LRKTAsEPNLKPRKD1HPRD
T70GSVDPtLREQQHDAC4_GlnPhosphoSitePlus
S291DGTVIsTFKKRPhosphoSitePlus
S498LSRTQsSPLPQPhosphoSitePlus
S498LSRTQsSPLPQCaMK1aRegPhos
S1108AAREHsPRPAEPhosphoSitePlus
S259LRKTAsEPNLKCaMK1aRegPhos
S259LRKTAsEPNLKCaMK4RegPhos
S1071AGLGRsLREAQArb2PhosphoSitePlus
S499LSRTQsSPLPQCAMK1HPRD
S498LSRTQsSPLPQCaMK4RegPhos
T547PRQPTtHPEETPhosphoSitePlus
S259LRKTAsEPNLKCAMK1HPRD
T496RPLSRtQSSPLPhosphoSitePlus
S55GGGSPsPVELRPhosphoSitePlus
S66GALVGsVDPTLHDAC4_GlnPhosphoSitePlus
T292GTVIStFKKRAPhosphoSitePlus
S755LLYGTsPLNRQHist_deacetylPhosphoSitePlus
T234SGPPGtPPSYKPhosphoSitePlus
S3___MNsPNESDPhosphoSitePlus

Dephosphorylation site
HDAC5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377244Q583ECOSMICOvarian Cancer21720365

Differential expressed protein
HDAC5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S279KVAERRSsPLLRRKDcardiomyopathy20716686PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD1_HUMANHDAC5_HUMANkinase -> substrateHPRD
KCC1A_HUMANHDAC5_HUMANkinase -> substrateHPRD
PKD1_HUMANHDAC5_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05169Epstein-Barr virus infection
hsa05203Viral carcinogenesis
hsa05034Alcoholism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032041NAD-dependent histone deacetylase activity (H3-K14IEAmolecular_function
GO:0097372NAD-dependent histone deacetylase activity (H3-K18IEAmolecular_function
GO:0006338chromatin remodelingTASbiological_process
GO:0016568chromatin modificationTASbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0051153regulation of striated muscle cell differentiationIEAbiological_process
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 IEAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0010832negative regulation of myotube differentiationIMPbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0042113B cell activationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0032869cellular response to insulin stimulusNASbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0043393regulation of protein bindingIMPbiological_process
GO:0004407histone deacetylase activityIDAmolecular_function
GO:0016604nuclear bodyIEAcellular_component
GO:0048742regulation of skeletal muscle fiber developmentIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIMPbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0006950response to stressIEAbiological_process
GO:0030183B cell differentiationTASbiological_process
GO:0002076osteoblast developmentIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0045668negative regulation of osteoblast differentiationIEAbiological_process
GO:0006342chromatin silencingTASbiological_process
GO:0046970NAD-dependent histone deacetylase activity (H4-K16IEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0010830regulation of myotube differentiationISSbiological_process
GO:0090051negative regulation of cell migration involved in IMPbiological_process
GO:0000118histone deacetylase complexTAScellular_component
GO:0005634nucleusIEAcellular_component
GO:0005080protein kinase C bindingIPImolecular_function
GO:0070491repressing transcription factor bindingIPImolecular_function
GO:0006325chromatin organizationTASbiological_process
GO:0042220response to cocaineIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0007507heart developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0016575histone deacetylationIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenTASbiological_process


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