| UniProt/SwissProt ID: | IF4A3_HUMAN |
| Description: | eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol;Acc:18683] |
| Location: | chr17 q25.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T163 | HVVAGtPGRVF | DEAD | PhosphoSitePlus |
| Y205 | QIYDVyRYLPP | DEAD | PhosphoSitePlus |
| Y202 | FKEQIyDVYRY | DEAD | PhosphoSitePlus |
| T4 | TMAT | HPRD | |
| T9 | TATMAtSGSAR | PhosphoSitePlus; HPRD | |
| S12 | MATSGsARKRL | PhosphoSitePlus; HPRD | |
| Y56 | RGIYAyGFEKP | PhosphoSitePlus | |
| Y155 | IRKLDyGQHVV | DEAD | PhosphoSitePlus |
| T6 | ATSG | HPRD | |
| Y54 | LLRGIyAYGFE | PhosphoSitePlus | |
| T163 | HVVAGtPGRVF | HPRD; phosphoELM | |
| S10 | ATMATsGSARK | PhosphoSitePlus; HPRD | |
| T247 | KRDELtLEGIK | PhosphoSitePlus | |
| Dephosphorylation site |
| IF4A3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000269349 | R370Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000269349 | A377P | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000269349 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000269349 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| Y54 | EDLLRGIyAYGFEKP | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus | |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PKN1_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK38_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDPK1_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGR_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1B_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCD_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCI_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDKL5_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BTK_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AAPK2_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| IF4A3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0004386 | helicase activity | IEA | molecular_function |
| GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0017148 | negative regulation of translation | IDA | biological_process |
| GO:0051028 | mRNA transport | IEA | biological_process |
| GO:0006364 | rRNA processing | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0048026 | positive regulation of mRNA splicing, via spliceos | IEA | biological_process |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0071013 | catalytic step 2 spliceosome | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0004004 | ATP-dependent RNA helicase activity | IDA | molecular_function |
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsen | IMP | biological_process |
| GO:0008143 | poly(A) RNA binding | IDA | molecular_function |
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deaden | TAS | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0035145 | exon-exon junction complex | IDA | cellular_component |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0000398 | mRNA splicing, via spliceosome | IC | biological_process |
| GO:0045727 | positive regulation of translation | IMP | biological_process |