Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GLI3_HUMAN
Description:GLI family zinc finger 3 [Source:HGNC Symbol;Acc:4319]
Location:chr7 p14.1
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S855SASTIsSAYLSPhosphoSitePlus
S445DEDLPsPGARGPhosphoSitePlus
S850NRRDSsASTISPhosphoSitePlus
T669SPGRPtQGALGPhosphoSitePlus; HPRD
T853DSSAStISSAYPhosphoSitePlus
S19KKVENsIVKCSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y104EPSVPyRGTVFPhosphoSitePlus
S980APRRCsDGGAHPhosphoSitePlus
S877SSRRSsEASQAPhosphoSitePlus
S865SSRRSsGISPCPhosphoSitePlus
Y933RLKAKyAAATGPhosphoSitePlus
S101HVAEPsVPYRGPhosphoSitePlus
S907ASRRSsEASQSPhosphoSitePlus
S849LNRRDsSASTIPhosphoSitePlus
T1539SSSRLtTPRASPhosphoSitePlus
S1006GVRRAsDPVRTPhosphoSitePlus
Y1254CKAPQyGNCLNPhosphoSitePlus
S664HSQSRsPGRPTPhosphoSitePlus; HPRD

Dephosphorylation site
GLI3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379258P940TCOSMICLung Cancer
ENSP00000379258S351CBIOMARTBreast Cancer21930507, 21930502
ENSP00000379258S1304PHPIColorectal Cancer16959974
ENSP00000379258S1304PSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000379258A1300VCOSMICLung Cancer20668451
ENSP00000379258T107MCOSMICPancreatic Cancer
ENSP00000379258P169LSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000379258L763WCOSMICLung Cancer20668451
ENSP00000379258G1055VCOSMICLung Cancer20668451
ENSP00000379258T418MCOSMICOvarian Cancer21720365
ENSP00000379258H123DCOSMICLung Cancer20668451
ENSP00000379258Q390RCOSMICLung Cancer20668451
ENSP00000379258P169LHPIColorectal Cancer16959974
ENSP00000379258R220HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000379258A235GCOSMICLung Cancer20668451
ENSP00000379258Y237*COSMICRenal Cancer20054297
ENSP00000379258Q670ECOSMICOvarian Cancer21720365
ENSP00000379258S276NCOSMICCentral Nervous System Neoplasms18772890
ENSP00000379258A1082TCOSMICOvarian Cancer20668451
ENSP00000379258G1255ECOSMICLung Cancer20668451

Differential expressed protein
GLI3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GLI3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GLI3_HUMANBCL2_HUMANTF -> target geneTRANSFAC
GLI3_HUMANPTC1_HUMANTF -> target geneTRANSFAC
GLI3_HUMANGLI1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
GLI3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0021801cerebral cortex radial glia guided migrationIEAbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0021798forebrain dorsal/ventral pattern formationIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0021543pallium developmentIEAbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0045879negative regulation of smoothened signaling pathwaIEAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0030879mammary gland developmentIEAbiological_process
GO:0035108limb morphogenesisIMPbiological_process
GO:0048593camera-type eye morphogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048557embryonic digestive tract morphogenesisIEAbiological_process
GO:0045595regulation of cell differentiationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0060367sagittal suture morphogenesisIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0060873anterior semicircular canal developmentIEAbiological_process
GO:0048566embryonic digestive tract developmentTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0022018lateral ganglionic eminence cell proliferationIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIDAbiological_process
GO:0060831smoothened signaling pathway involved in dorsal/veIEAbiological_process
GO:0021631optic nerve morphogenesisIEAbiological_process
GO:0005929ciliumIDAcellular_component
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0048709oligodendrocyte differentiationIEAbiological_process
GO:0060021palate developmentIEAbiological_process
GO:0001656metanephros developmentIEAbiological_process
GO:0002052positive regulation of neuroblast proliferationIEAbiological_process
GO:0035035histone acetyltransferase bindingIPImolecular_function
GO:0021537telencephalon developmentIEAbiological_process
GO:0060364frontal suture morphogenesisIEAbiological_process
GO:0030318melanocyte differentiationIEAbiological_process
GO:0060594mammary gland specificationIEAbiological_process
GO:0007417central nervous system developmentIEAbiological_process
GO:0046638positive regulation of alpha-beta T cell differentIEAbiological_process
GO:0048704embryonic skeletal system morphogenesisIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0043586tongue developmentIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0021544subpallium developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0033077T cell differentiation in thymusISSbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0007224smoothened signaling pathwayIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0048646anatomical structure formation involved in morphogIEAbiological_process
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0042307positive regulation of protein import into nucleusIEAbiological_process
GO:0070242thymocyte apoptotic processIEAbiological_process
GO:0048598embryonic morphogenesisIEAbiological_process
GO:0021775smoothened signaling pathway involved in ventral sIEAbiological_process
GO:0048856anatomical structure developmentIEAbiological_process
GO:0032332positive regulation of chondrocyte differentiationIEAbiological_process
GO:0061005cell differentiation involved in kidney developmenIEAbiological_process
GO:0017053transcriptional repressor complexIEAcellular_component
GO:0021861forebrain radial glial cell differentiationIEAbiological_process
GO:0021513spinal cord dorsal/ventral patterningIEAbiological_process
GO:0045060negative thymic T cell selectionIEAbiological_process
GO:0046639negative regulation of alpha-beta T cell differentIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0060366lambdoid suture morphogenesisIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0008013beta-catenin bindingIPImolecular_function
GO:0035108limb morphogenesisIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0060840artery developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0005634nucleusIEAcellular_component
GO:0048566embryonic digestive tract developmentIEAbiological_process
GO:0048663neuron fate commitmentIEAbiological_process
GO:0007224smoothened signaling pathwayTASbiological_process
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0060875lateral semicircular canal developmentIEAbiological_process
GO:0021915neural tube developmentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0016485protein processingIEAbiological_process
GO:0048589developmental growthIEAbiological_process
GO:0035295tube developmentIEAbiological_process
GO:0021776smoothened signaling pathway involved in spinal coIEAbiological_process
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:0007442hindgut morphogenesisIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0043585nose morphogenesisTASbiological_process
GO:0016592mediator complexIDAcellular_component
GO:0060173limb developmentIEAbiological_process
GO:0009954proximal/distal pattern formationIEAbiological_process
GO:0043010camera-type eye developmentIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0042826histone deacetylase bindingIDAmolecular_function