Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FYV1_HUMAN
Description:phosphoinositide kinase, FYVE finger containing [Source:HGNC Symbol;Acc:23785]
Location:chr2 q34
Node attribute:PPI(target); Enzyme(target); Enzyme(source); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1301LKELDsPVPGYPhosphoSitePlus
S491DNLANsASPSKPhosphoSitePlus; HPRD
T7PTLDHPRD; SysPTM
S104ELQRRsSALDTPhosphoSitePlus
S105LQRRSsALDTRPhosphoSitePlus
S452TPSPDsDSVNSPhosphoSitePlus
T342VRTETtEDERKPhosphoSitePlus
S454SPDSDsVNSVEPhosphoSitePlus
S1549SPRNIsPGLQNPhosphoSitePlus; HPRD; SysPTM
S457SDSVNsVEGHSPhosphoSitePlus
S378IKFDDsDTEQIHPRD
Y46PFKSAySSFVNPhosphoSitePlus; phosphoELM
T7ATDDKtSPTLDPhosphoSitePlus; SysPTM
S329YETSVsPQANRPhosphoSitePlus; HPRD; phosphoELM
T583KELPFtPLGWHPhosphoSitePlus
S475IKFDDsDTEQIPhosphoSitePlus; HPRD
T173SEKFTtFRRRHFYVEPhosphoSitePlus
S274DLAWQsLIHPDPhosphoSitePlus
S367ICHHSsGMEFQPhosphoSitePlus
T477FDDSDtEQIAEPhosphoSitePlus; HPRD
S316LSLDRsGSPMVPhosphoSitePlus
S1770LRGADsAYYQVPhosphoSitePlus
S1111LLRDLsGLQGMPhosphoSitePlus
T109SSALDtRRKAEPhosphoSitePlus
T1764SQKREtLRGADPhosphoSitePlus
T309RSASItNLSLDPhosphoSitePlus
S1167IQPKNsDPFAHPhosphoSitePlus
T326VPSYEtSVSPQPhosphoSitePlus
T133LRSLStVLKRLPhosphoSitePlus
S318LDRSGsPMVPSPhosphoSitePlus; HPRD; phosphoELM
S232YETSVsPQANRHPRD
S1714RPKSSsPIRLPPhosphoSitePlus; HPRD; phosphoELM
T335PQANRtYVRTEPhosphoSitePlus
S44EPPFKsAYSSFPhosphoSitePlus
S1544SAMDAsPRNISPhosphoSitePlus; HPRD; SysPTM
Y1772GADSAyYQVGQPhosphoSitePlus; HPRD; phosphoELM
S71EQQPLsGSWTSHPRD
S1124SIQAKsIQVLPPhosphoSitePlus
T822LPNEQtKTLMFHPRD; SysPTM
T380FDDSDtEQIAEHPRD
S1526PSVPPsPGRLRPhosphoSitePlus
Y324PMVPSyETSVSPhosphoSitePlus
S1440KTDTFsKTREEPhosphoSitePlus
T341YVRTEtTEDERPhosphoSitePlus
S394DNLANsASPSKHPRD
S210RNRSAsITNLSHPRD
T1479SSSVDtPQQLQPhosphoSitePlus
T34HFKPLtPDQDEPhosphoSitePlus; HPRD
S76SGSWTsPQLPSPhosphoSitePlus; HPRD; SysPTM
T1312QHTILtYSWCRPhosphoSitePlus
S307RNRSAsITNLSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S48KSAYSsFVNLFPhosphoSitePlus
S88TQSVRsPTPYKPhosphoSitePlus
S291STRLVsVQEDAPhosphoSitePlus
S1177HSKDAsSTSSGPhosphoSitePlus
S1496IAKKQsLCEVLPhosphoSitePlus
S1712DSRPKsSSPIRHPRD
Y1773ADSAYyQVGQTPhosphoSitePlus
S261GSRKAsRNIFLPhosphoSitePlus
S493LANSAsPSKRTPhosphoSitePlus
S366KICHHsSGMEFPhosphoSitePlus
S255KILLDsVQLKDHPRD
S299EDAGKsPARNRPhosphoSitePlus; HPRD; SysPTM
S202EDAGKsPARNRHPRD
S1474QARLMsSSVDTPhosphoSitePlus
Y1350FYGHQyTRRANPhosphoSitePlus
S221LDRSGsPMVPSHPRD
S1522GRKRPsVPPSPPhosphoSitePlus
T822LPNEQtKTLMFCpn60_TCP1PhosphoSitePlus; SysPTM
Y154SDLKQyWMPDSFYVEPhosphoSitePlus
S1754GTAGKsPDLSSPhosphoSitePlus; HPRD; SysPTM
S327PSYETsVSPQAPhosphoSitePlus
Y1155RMLADyRARGGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S307RNRSAsITNLSPKB_groupphosphoELM; SysPTM
T1436LASLKtDTFSKPhosphoSitePlus
T339RTYVRtETTEDPhosphoSitePlus
S305PARNRsASITNPhosphoSitePlus
S1475ARLMSsSVDTPPhosphoSitePlus
S845KLRGGsDYELACpn60_TCP1PhosphoSitePlus
S888LMQNPsFHSLIPhosphoSitePlus
S312SITNLsLDRSGPhosphoSitePlus
S449FSETPsPDSDSPhosphoSitePlus
S2068MPTVVsPELYRPIP5KPhosphoSitePlus
S352KILLDsVQLKDPhosphoSitePlus; HPRD; SysPTM

Dephosphorylation site
FYV1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264380D1300NCOSMICOvarian Cancer21720365
ENSP00000264380P919HCOSMICOvarian Cancer21720365
ENSP00000264380R1766PCOSMICHead and Neck Cancer21798893
ENSP00000264380R1984*COSMICOvarian Cancer21720365
ENSP00000264380W74CCOSMICOvarian Cancer21720365
ENSP00000264380F1673YCOSMICMelanoma21499247
ENSP00000264380K1802RCOSMICRenal Cancer20054297
ENSP00000264380R396*COSMICSkin Cancer21984974
ENSP00000264380K1446*COSMICOvarian Cancer21720365
ENSP00000384356W74CTCGAOvarian Cancer21720365, 18772890
ENSP00000264380G1592RCOSMICRenal Cancer20054297
ENSP00000264380S323*COSMICCentral Nervous System Neoplasms18772396
ENSP00000264380H1851QCOSMICHead and Neck Cancer21798893
ENSP00000264380R1471KCOSMICOvarian Cancer21720365
ENSP00000264380L1530VCOSMICOvarian Cancer21720365

Differential expressed protein
FYV1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FYV1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ROCK1_HUMANFYV1_HUMANkinase -> substrateKEGG
FYV1_HUMANPI3R5_HUMANenzyme catalysisKEGG
FYV1_HUMANMTM1_HUMANenzyme catalysisKEGG
PI3R5_HUMANFYV1_HUMANenzyme catalysisKEGG
PLCD3_HUMANFYV1_HUMANenzyme catalysisKEGG
FYV1_HUMANPI42A_HUMANenzyme catalysisKEGG
CDIPT_HUMANFYV1_HUMANenzyme catalysisKEGG
FYV1_HUMANPI4KA_HUMANenzyme catalysisKEGG
PTEN_HUMANFYV1_HUMANenzyme catalysisKEGG
INP4A_HUMANFYV1_HUMANenzyme catalysisKEGG
VINC_HUMANFYV1_HUMANotherKEGG
FYV1_HUMANGELS_HUMANotherKEGG
FYV1_HUMANACTN4_HUMANotherKEGG
FYV1_HUMANVINC_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04070Phosphatidylinositol signaling system
hsa00562Inositol phosphate metabolism
hsa04145Phagosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000139Golgi membraneTAScellular_component
GO:0042147retrograde transport, endosome to GolgiIMPbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0045121membrane raftIDAcellular_component
GO:0016307phosphatidylinositol phosphate kinase activityIEAmolecular_function
GO:0046488phosphatidylinositol metabolic processIEAbiological_process
GO:00002851-phosphatidylinositol-3-phosphate 5-kinase activiIEAmolecular_function
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0036092phosphatidylinositol-3-phosphate biosynthetic procTASbiological_process
GO:0010008endosome membraneIDAcellular_component
GO:0031901early endosome membraneIDAcellular_component
GO:0034504protein localization to nucleusIMPbiological_process
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activiTASmolecular_function
GO:0043813phosphatidylinositol-3,5-bisphosphate 5-phosphatasTASmolecular_function
GO:0031902late endosome membraneTAScellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0006644phospholipid metabolic processTASbiological_process
GO:0032288myelin assemblyIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0044267cellular protein metabolic processIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolIEAcellular_component


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