Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACTN4_HUMAN
Description:actinin, alpha 4 [Source:HGNC Symbol;Acc:166]
Location:chr19 q13.2
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S263MTYVSsFYHAFCHPhosphoSitePlus
Y31GSMGDyMAQEDPhosphoSitePlus
S656RRQFAsQANVVSpectrinPhosphoSitePlus
Y485LNELDyYDSHNSpectrinPhosphoSitePlus
T682IEMNGtLEDQLSpectrinPhosphoSitePlus
Y878PDQAEyCIARMefhand_Ca_insenPhosphoSitePlus
Y265YVSSFyHAFSGHPRD; phosphoELM
Y234EVAEKyLDIPKCHPhosphoSitePlus
S92LLEVIsGERLPCHPhosphoSitePlus
T142GNAKMtLGMIWCHPhosphoSitePlus
Y693SHLKQyERSIVSpectrinPhosphoSitePlus
Y265YVSSFyHAFSGCHPhosphoSitePlus
S621PQIINsKWEKVSpectrinPhosphoSitePlus
S461HEAFEsDLAAHSpectrinPhosphoSitePlus
T312EWIRRtIPWLESpectrinPhosphoSitePlus
S447ETATLsDIKALSpectrinPhosphoSitePlus
Y212PELIEyDKLRKCHPhosphoSitePlus
S269FYHAFsGAQKACHPhosphoSitePlus
S423FRQKAsIHEAWSpectrinPhosphoSitePlus
Y260KAIMTyVSSFYCHPhosphoSitePlus
T667GPWIQtKMEEISpectrinPhosphoSitePlus
Y727NKHTNyTMEHISpectrinPhosphoSitePlus
Y700RSIVDyKPNLDSpectrinPhosphoSitePlus
S159AIQDIsVEETSPhosphoSitePlus; HPRD; phosphoELM
S262IMTYVsSFYHACHPhosphoSitePlus
T756ENQILtRDAKGEF_hand_5PhosphoSitePlus
Y4__MVDyHAANQPhosphoSitePlus
Y486NELDYyDSHNVSpectrinPhosphoSitePlus
T493SHNVNtRCQKISpectrinPhosphoSitePlus
S488LDYYDsHNVNTSpectrinPhosphoSitePlus

Dephosphorylation site
ACTN4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000252699S375FCOSMICSkin Cancer21984974
ENSP00000252699D685GBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000252699Pancreatic CancerNormal vs. CancertissueUp5.216215274
ENSP00000252699Gastric CancerMetastasiscell lineUp1.417022644
ENSP00000252699Breast CancerNormal vs. Cancercell lineDown0.2316596714
ENSP00000252699Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000252699Gastric CancerMetastasiscell lineUp1.417022644
ENSP00000252699Breast CancerNormal vs. CancertissueUp4.820005186
ENSP00000252699breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000252699Renal CancerNormal vs. CancertissueDown19164279
ENSP00000252699Ovarian CancerMetastasiscell lineDown0.3317892554
ENSP00000252699Pancreatic CancerNormal vs. CancertissueUp215526344

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y265CHMTYVSSFyHAFSGAQcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
FYV1_HUMANACTN4_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa05146Amoebiasis
hsa05322Systemic lupus erythematosus
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04510Focal adhesion
hsa04520Adherens junction
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0051015actin filament bindingIDAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0043234protein complexIDAcellular_component
GO:0002576platelet degranulationTASbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0042803protein homodimerization activityTASmolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0051272positive regulation of cellular component movementIMPbiological_process
GO:0031143pseudopodiumTAScellular_component
GO:0030018Z discIEAcellular_component
GO:0051271negative regulation of cellular component movementIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0031143pseudopodiumIEAcellular_component
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0005178integrin bindingTASmolecular_function
GO:0051764actin crosslink formationIEAbiological_process
GO:0003779actin bindingTASmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0015031protein transportIEAbiological_process
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0001882nucleoside bindingIDAmolecular_function
GO:0032403protein complex bindingIEAmolecular_function
GO:0043234protein complexIEAcellular_component
GO:0051015actin filament bindingIEAmolecular_function
GO:0042981regulation of apoptotic processNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0032417positive regulation of sodium:hydrogen antiporter NASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0047485protein N-terminus bindingIEAmolecular_function
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0005576extracellular regionTAScellular_component
GO:0051017actin filament bundle assemblyIEAbiological_process
GO:0030863cortical cytoskeletonIEAcellular_component
GO:0048549positive regulation of pinocytosisIEAbiological_process
GO:0005634nucleusIEAcellular_component